GB1265788A - - Google Patents
Info
- Publication number
- GB1265788A GB1265788A GB1434470A GB1265788DA GB1265788A GB 1265788 A GB1265788 A GB 1265788A GB 1434470 A GB1434470 A GB 1434470A GB 1265788D A GB1265788D A GB 1265788DA GB 1265788 A GB1265788 A GB 1265788A
- Authority
- GB
- United Kingdom
- Prior art keywords
- give
- compounds
- dimethylfuran
- reacted
- alkyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/42—Oxazoles
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
- C07D307/34—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D307/56—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D307/66—Nitrogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
- C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
- C07D333/26—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D333/30—Hetero atoms other than halogen
- C07D333/36—Nitrogen atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Abstract
1,265,788. Oxazoiinylamino compounds. E. I. DU PONT DE NEMOURS & CO. 1 April, 1970 [24 March, 1970], No. 14344/70. Heading C2C. The invention comprises compounds of formula and their acid addition salts, wherein R, R<SP>1</SP> are each H, Cl or C 1-3 alkyl, or R-R<SP>1</SP> form a fused ring (when the oxazolinylamino group is attached to either ring in the bicyclic system), Q is 0 or S, m is 1 or 2, and A, X, D, Z are each H or C 1-4 alkyl but total less than 9 C atoms. These compounds are prepared by reacting together, in an inert solvent, an aminofuran or aminothiophene with a C1CA(X)CD(Z)NCO to give the corresponding 3-(2-chloroethylureido)- furan or -thiophene, refluxing the latter with water to give the HCl-salt of the desired base, and obtaining the latter by adding NH 4 OH. Alternatively (e.g.) 3 - chlorocarbonyl - 2,5 - dimethylfuran is reacted with NaN 3 to give the corresponding azide, which is heated in toluene to give 3-isocyanato-2,5-dimethylfuran and this is reacted with 2-chloroethylamine to give the corresponding ureide which is converted to the desired product as above. Pharmaceutical and veterinary compositions for administration orally, parenterally, or by means of vapour or spray, comprise compounds of the above formula, which have antihypertensive and C.N.S. depressant activity.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US47905565A | 1965-08-10 | 1965-08-10 | |
GB1434470 | 1970-03-24 | ||
DE19702043188 DE2043188A1 (en) | 1965-08-10 | 1970-09-01 | New oxazole indenvates, their manufacture and use |
Publications (1)
Publication Number | Publication Date |
---|---|
GB1265788A true GB1265788A (en) | 1972-03-08 |
Family
ID=27182844
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
GB1434470A Expired GB1265788A (en) | 1965-08-10 | 1970-03-24 |
Country Status (3)
Country | Link |
---|---|
US (1) | US3499084A (en) |
DE (1) | DE2043188A1 (en) |
GB (1) | GB1265788A (en) |
Families Citing this family (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
ES442992A1 (en) * | 1974-12-02 | 1977-08-01 | Scherico Ltd | Para-polyfluoroisopropyl-anilino-2-oxazoline compounds, pharmaceutical compositions and method of treating hypertension |
US4256755A (en) * | 1980-04-28 | 1981-03-17 | E. I. Du Pont De Nemours & Company | Method of using N-substituted dihydro-2-oxazolamines as analgesics |
US4861791A (en) * | 1983-08-29 | 1989-08-29 | Sterling Drug Inc. | Dihydro-oxazolyl substituted-phenyl-aliphatic lower alkyl and their use as antiviral agents |
GB0615670D0 (en) * | 2006-08-07 | 2006-09-13 | Syngenta Participations Ag | Chemical compounds |
EP2014168A1 (en) * | 2007-06-19 | 2009-01-14 | Bayer CropScience AG | Insecticidal heterocyclic compounds |
Family Cites Families (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US2870160A (en) * | 1957-07-08 | 1959-01-20 | Pfizer & Co C | 2 (benzofuranyl amino)-and 2 (thianaphthenyl amino) oxazolines |
-
1965
- 1965-08-10 US US479055A patent/US3499084A/en not_active Expired - Lifetime
-
1970
- 1970-03-24 GB GB1434470A patent/GB1265788A/en not_active Expired
- 1970-09-01 DE DE19702043188 patent/DE2043188A1/en active Pending
Also Published As
Publication number | Publication date |
---|---|
DE2043188A1 (en) | 1972-03-02 |
US3499084A (en) | 1970-03-03 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
PS | Patent sealed [section 19, patents act 1949] | ||
PLNP | Patent lapsed through nonpayment of renewal fees |