GB1260907A - Indole derivatives - Google Patents
Indole derivativesInfo
- Publication number
- GB1260907A GB1260907A GB2658169A GB2658169A GB1260907A GB 1260907 A GB1260907 A GB 1260907A GB 2658169 A GB2658169 A GB 2658169A GB 2658169 A GB2658169 A GB 2658169A GB 1260907 A GB1260907 A GB 1260907A
- Authority
- GB
- United Kingdom
- Prior art keywords
- reacting
- methylindole
- hydroxy
- benzyl
- epibromohydrin
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/08—Indoles; Hydrogenated indoles with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, directly attached to carbon atoms of the hetero ring
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Indole Compounds (AREA)
Abstract
1,260,907. Indole derivatives. SANDOZ Ltd. 23 May, 1969 [10 Dec., 1968; 7 June, 1968; 4 Sept., 1968], No. 26581/69. Addition to 1,238,968. Heading C2C. Compounds of the formula (R=H, CH 3 ) and their salts are prepared by (a) reacting 4-hydroxy-2-methylindole with epichlorohydrin or epibromohydrin in an alkaline medium, reacting the product with isopropylamine or tert.-butylamine or their N-benzyl derivatives and removing any benzyl group present, (b) reacting benzylisopropylamine or benzyl tert.-butylamine with epichlorohydrin or epibromohydrin, reacting the product with 4- hydroxy-2-methylindole in an alkaline medium and removing any benzyl group present or (c) reducing 4-(2-hydroxy-3-isopropylidenaminopropoxy)-2-methylindole, optionally followed in each case by salt formation. The above compounds are #-adrenergic blocking agents and may be administered in the form of pharmaceutical preparations containing them in association with a carrier.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
BR17682968 | 1968-06-07 | ||
DE19681620342 DE1620342A1 (en) | 1965-02-01 | 1968-09-04 | Process for the production of new indole derivatives |
CH1838768A CH502337A (en) | 1965-02-01 | 1968-12-10 | Indole derivs - adrenergic beta blockers |
Publications (1)
Publication Number | Publication Date |
---|---|
GB1260907A true GB1260907A (en) | 1972-01-19 |
Family
ID=27160205
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
GB2658169A Expired GB1260907A (en) | 1968-06-07 | 1969-05-23 | Indole derivatives |
Country Status (2)
Country | Link |
---|---|
CS (1) | CS159759B2 (en) |
GB (1) | GB1260907A (en) |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB2173399A (en) * | 1985-02-05 | 1986-10-15 | Sandoz Ltd | Compositions containing 3-aminopropoxy-indoles for treating hypertension |
-
1969
- 1969-05-23 GB GB2658169A patent/GB1260907A/en not_active Expired
- 1969-06-05 CS CS399869A patent/CS159759B2/cs unknown
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB2173399A (en) * | 1985-02-05 | 1986-10-15 | Sandoz Ltd | Compositions containing 3-aminopropoxy-indoles for treating hypertension |
AT393960B (en) * | 1985-02-05 | 1992-01-10 | Sandoz Ag | METHOD FOR COMBINING A BETA ADRENO RECEPTOR BLOCKER AND A DIURETIC |
Also Published As
Publication number | Publication date |
---|---|
CS159759B2 (en) | 1975-01-31 |
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