GB1248146A - PREPARATION OF IMIDAZO[4,5-b]PYRAZINES - Google Patents

PREPARATION OF IMIDAZO[4,5-b]PYRAZINES

Info

Publication number
GB1248146A
GB1248146A GB4218569A GB4218569A GB1248146A GB 1248146 A GB1248146 A GB 1248146A GB 4218569 A GB4218569 A GB 4218569A GB 4218569 A GB4218569 A GB 4218569A GB 1248146 A GB1248146 A GB 1248146A
Authority
GB
United Kingdom
Prior art keywords
alkyl
group
diuretic
aug
hydrogen atom
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB4218569A
Inventor
Roger James Tull
Peter Immanuel Pollak
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merck and Co Inc
Original Assignee
Merck and Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck and Co Inc filed Critical Merck and Co Inc
Publication of GB1248146A publication Critical patent/GB1248146A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
    • C07D241/02—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings
    • C07D241/10—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
    • C07D241/14—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D241/24—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D241/26—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with nitrogen atoms directly attached to ring carbon atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

1,248,146. Diuretic &c. medicines. MERCK & CO. Inc. 25 Aug., 1969 [31 Aug., 1968], No. 42185/69. Heading A5B. [Also in Division C2] Pharmaceutical compositions having antihypertensive, diuretic and saluretic activity comprise, as active ingredient, a 5-amino-6- chloro-1H-imidazo [4, 5-6] pyrazin-2-one of the general formula: wherein R and X 1 are each a hydrogen atom or a C 1-5 alkyl group and X 2 is a hydrogen atom or a C 1-5 alkyl, alkoxy-C 1-5 alkyl, monocyclic aryl (optionally halo-substituted), pyridyl, vinyl, acetamidomethyl, 2-isopropylaminoethyl, 2-acetamidoethyl or di-(C 1-5 alkyl)-aminoalkyl group or an aminoalkyl group, the nitrogen atom of which forms part of a saturated 5-or 6-membered heterocyclic ring optionally containing an unsubstituted or C 1-5 alkyl-substituted imino group or an oxygen atom, or X 1 and X 2 may together form a tetramethylene radical, together with a pharmaceutical diluent or excipient and, optionally, further therapeutic agents, and may be administered orally or parenterally as pills, tablets, capsules, elixirs or injectable preparations.
GB4218569A 1968-08-31 1969-08-25 PREPARATION OF IMIDAZO[4,5-b]PYRAZINES Expired GB1248146A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CA28998 1968-08-31

Publications (1)

Publication Number Publication Date
GB1248146A true GB1248146A (en) 1971-09-29

Family

ID=4084476

Family Applications (1)

Application Number Title Priority Date Filing Date
GB4218569A Expired GB1248146A (en) 1968-08-31 1969-08-25 PREPARATION OF IMIDAZO[4,5-b]PYRAZINES

Country Status (5)

Country Link
AT (1) AT292712B (en)
BR (1) BR6911905D0 (en)
ES (1) ES370718A1 (en)
GB (1) GB1248146A (en)
NL (1) NL6911868A (en)

Cited By (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2368843A (en) * 2000-11-08 2002-05-15 Leuven K U Res & Dev Non-porphyrin multipurpose contrast agents
WO2011009943A1 (en) 2009-07-24 2011-01-27 Novartis Ag Oxazine derivatives and their use as bace inhibitors for the treatment of neurological disorders
WO2011080176A1 (en) 2009-12-31 2011-07-07 Novartis Ag Pyrazine derivatives and their use in the treatment of neurological disorders
WO2012095469A1 (en) 2011-01-13 2012-07-19 Novartis Ag Novel heterocyclic derivatives and their use in the treatment of neurological disorders
WO2012095463A1 (en) 2011-01-12 2012-07-19 Novartis Ag Oxazine derivatives and their use in the treatment of neurological disorders
EP3023423A1 (en) 2011-08-25 2016-05-25 Novartis AG 2 -amino-4 - (pyridin- 2 -yl) - 5, 6 -dihydro-4h- 1, 3 -oxazine derivatives and their use as bace-1 and/or bace - 2 inhibitors

Cited By (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2368843A (en) * 2000-11-08 2002-05-15 Leuven K U Res & Dev Non-porphyrin multipurpose contrast agents
WO2011009943A1 (en) 2009-07-24 2011-01-27 Novartis Ag Oxazine derivatives and their use as bace inhibitors for the treatment of neurological disorders
WO2011080176A1 (en) 2009-12-31 2011-07-07 Novartis Ag Pyrazine derivatives and their use in the treatment of neurological disorders
WO2012095463A1 (en) 2011-01-12 2012-07-19 Novartis Ag Oxazine derivatives and their use in the treatment of neurological disorders
WO2012095469A1 (en) 2011-01-13 2012-07-19 Novartis Ag Novel heterocyclic derivatives and their use in the treatment of neurological disorders
EP3023423A1 (en) 2011-08-25 2016-05-25 Novartis AG 2 -amino-4 - (pyridin- 2 -yl) - 5, 6 -dihydro-4h- 1, 3 -oxazine derivatives and their use as bace-1 and/or bace - 2 inhibitors

Also Published As

Publication number Publication date
BR6911905D0 (en) 1973-04-26
AT292712B (en) 1971-09-10
NL6911868A (en) 1970-03-03
ES370718A1 (en) 1971-10-16

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