GB1245316A - Novel quinazolinone derivative and process for production thereof - Google Patents
Novel quinazolinone derivative and process for production thereofInfo
- Publication number
- GB1245316A GB1245316A GB49142/69A GB4914269A GB1245316A GB 1245316 A GB1245316 A GB 1245316A GB 49142/69 A GB49142/69 A GB 49142/69A GB 4914269 A GB4914269 A GB 4914269A GB 1245316 A GB1245316 A GB 1245316A
- Authority
- GB
- United Kingdom
- Prior art keywords
- methyl
- production
- novel
- quinazolinone derivative
- quinazolin
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- AVRPFRMDMNDIDH-UHFFFAOYSA-N 1h-quinazolin-2-one Chemical class C1=CC=CC2=NC(O)=NC=C21 AVRPFRMDMNDIDH-UHFFFAOYSA-N 0.000 title abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 2
- FIEYHAAMDAPVCH-UHFFFAOYSA-N 2-methyl-1h-quinazolin-4-one Chemical compound C1=CC=C2NC(C)=NC(=O)C2=C1 FIEYHAAMDAPVCH-UHFFFAOYSA-N 0.000 abstract 1
- LYTDCCLXRGTWMX-UHFFFAOYSA-N 2-methyl-3-(oxiran-2-ylmethyl)quinazolin-4-one Chemical compound CC1=NC2=CC=CC=C2C(N1CC1CO1)=O LYTDCCLXRGTWMX-UHFFFAOYSA-N 0.000 abstract 1
- SLBNBTYQYOJGTQ-UHFFFAOYSA-N 3-(3-bromo-2-hydroxypropyl)-2-methylquinazolin-4-one Chemical compound CC1=NC2=CC=CC=C2C(N1CC(CBr)O)=O SLBNBTYQYOJGTQ-UHFFFAOYSA-N 0.000 abstract 1
- HZRUYXITKXZLOS-UHFFFAOYSA-N 3-[2-hydroxy-3-(4-phenylpiperazin-1-yl)propyl]-2-methylquinazolin-4-one Chemical compound CC1=NC2=CC=CC=C2C(=O)N1CC(O)CN(CC1)CCN1C1=CC=CC=C1 HZRUYXITKXZLOS-UHFFFAOYSA-N 0.000 abstract 1
- BRLQWZUYTZBJKN-UHFFFAOYSA-N Epichlorohydrin Chemical compound ClCC1CO1 BRLQWZUYTZBJKN-UHFFFAOYSA-N 0.000 abstract 1
- 229940035676 analgesics Drugs 0.000 abstract 1
- 230000000954 anitussive effect Effects 0.000 abstract 1
- 239000000730 antalgic agent Substances 0.000 abstract 1
- 239000003434 antitussive agent Substances 0.000 abstract 1
- 229940124584 antitussives Drugs 0.000 abstract 1
- 238000011065 in-situ storage Methods 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- YZTJYBJCZXZGCT-UHFFFAOYSA-N phenylpiperazine Chemical compound C1CNCCN1C1=CC=CC=C1 YZTJYBJCZXZGCT-UHFFFAOYSA-N 0.000 abstract 1
- QVWDCTQRORVHHT-UHFFFAOYSA-N tropone Chemical compound O=C1C=CC=CC=C1 QVWDCTQRORVHHT-UHFFFAOYSA-N 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
-
- H—ELECTRICITY
- H01—ELECTRIC ELEMENTS
- H01F—MAGNETS; INDUCTANCES; TRANSFORMERS; SELECTION OF MATERIALS FOR THEIR MAGNETIC PROPERTIES
- H01F27/00—Details of transformers or inductances, in general
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Power Engineering (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
1,245,316. Quinazolinone derivative. TROPON G.m.b.H., [trading as TROPONWERKE DINKLAGE & CO.]. 7 Oct., 1969 [16 Oct., 1968], No. 49142/69. Heading C2C. Novel 2 - methyl - 3 - {3 - (4 - phenylpiperazin - 1 - yl) - 2 - hydroxy - propyl}- quinazolin-4-one is prepared by reaction of 1- phenyl-piperazine with 2-methyl-3-(3-bromo-2- hydroxypropyl) - quinazolin - 4 - one or 2- methyl - 3 - (2,3 - epoxypropyl) - quinazoline-4- one, which latter compound may be prepared in situ by reaction of 2-methyl-quinazoline-4-one with epichlorohydrin. Pharmaceutical compositions comprise the novel compound together with a suitable carrier and are administered orally as analgesics and antitussives.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE19681803210 DE1803210A1 (en) | 1968-10-16 | 1968-10-16 | 2-Methyl-3- (3- [4-phenylpiperazinyl- (1)] -2-hydroxypropyl) -quinazolinone- (4) and process for its preparation |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB1245316A true GB1245316A (en) | 1971-09-08 |
Family
ID=5710568
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB49142/69A Expired GB1245316A (en) | 1968-10-16 | 1969-10-07 | Novel quinazolinone derivative and process for production thereof |
Country Status (7)
| Country | Link |
|---|---|
| US (1) | US3652567A (en) |
| CH (1) | CH531524A (en) |
| DE (1) | DE1803210A1 (en) |
| FI (1) | FI52725C (en) |
| FR (1) | FR2020814B1 (en) |
| GB (1) | GB1245316A (en) |
| SE (1) | SE378422B (en) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE1936588A1 (en) * | 1969-07-18 | 1971-02-18 | Troponwerke Dinklage & Co | Pharmacologically active quinazolinone compound, its use in pharmacological preparations and process for its manufacture |
| US3879393A (en) * | 1973-06-18 | 1975-04-22 | Miles Lab | Derivatives of 1,3-disubstituted 2,4(1h,3h)-quinazolinediones |
| DE4203050C2 (en) * | 1992-02-04 | 1994-03-17 | Heiko Delecate | Electric motor assembly and air motor assembly |
| TW200306839A (en) | 2002-02-06 | 2003-12-01 | Novartis Ag | Quinazolinone derivatives and their use as CB agonists |
| GB0413618D0 (en) * | 2004-06-17 | 2004-07-21 | Novartis Ag | Organic compounds |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3231572A (en) * | 1963-08-05 | 1966-01-25 | Miles Lab | 3-substituted-4-quinazolones |
-
1968
- 1968-10-16 DE DE19681803210 patent/DE1803210A1/en active Pending
-
1969
- 1969-10-06 CH CH1496969A patent/CH531524A/en not_active IP Right Cessation
- 1969-10-07 GB GB49142/69A patent/GB1245316A/en not_active Expired
- 1969-10-13 FI FI692935A patent/FI52725C/en active
- 1969-10-14 FR FR6935205A patent/FR2020814B1/fr not_active Expired
- 1969-10-15 US US866719A patent/US3652567A/en not_active Expired - Lifetime
- 1969-10-16 SE SE6914231A patent/SE378422B/xx unknown
Also Published As
| Publication number | Publication date |
|---|---|
| FI52725C (en) | 1977-11-10 |
| FR2020814B1 (en) | 1974-02-01 |
| DE1803210A1 (en) | 1970-05-14 |
| FR2020814A1 (en) | 1970-07-17 |
| SE378422B (en) | 1975-09-01 |
| FI52725B (en) | 1977-08-01 |
| US3652567A (en) | 1972-03-28 |
| CH531524A (en) | 1972-12-15 |
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