GB1241655A - Improvements in or relating to cephalosporin compounds - Google Patents
Improvements in or relating to cephalosporin compoundsInfo
- Publication number
- GB1241655A GB1241655A GB3849267A GB3849267A GB1241655A GB 1241655 A GB1241655 A GB 1241655A GB 3849267 A GB3849267 A GB 3849267A GB 3849267 A GB3849267 A GB 3849267A GB 1241655 A GB1241655 A GB 1241655A
- Authority
- GB
- United Kingdom
- Prior art keywords
- group
- halide
- cephalosporin compounds
- blocked
- imide
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- -1 cephalosporin compounds Chemical class 0.000 title abstract 7
- 229940124587 cephalosporin Drugs 0.000 title abstract 5
- 229930186147 Cephalosporin Natural products 0.000 title abstract 4
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 abstract 3
- ZMANZCXQSJIPKH-UHFFFAOYSA-N Triethylamine Chemical compound CCN(CC)CC ZMANZCXQSJIPKH-UHFFFAOYSA-N 0.000 abstract 3
- ODUCDPQEXGNKDN-UHFFFAOYSA-N nitroxyl Chemical compound O=N ODUCDPQEXGNKDN-UHFFFAOYSA-N 0.000 abstract 3
- QGZKDVFQNNGYKY-UHFFFAOYSA-N Ammonia Chemical compound N QGZKDVFQNNGYKY-UHFFFAOYSA-N 0.000 abstract 2
- VTYYLEPIZMXCLO-UHFFFAOYSA-L Calcium carbonate Chemical compound [Ca+2].[O-]C([O-])=O VTYYLEPIZMXCLO-UHFFFAOYSA-L 0.000 abstract 2
- JUJWROOIHBZHMG-UHFFFAOYSA-N Pyridine Chemical compound C1=CC=NC=C1 JUJWROOIHBZHMG-UHFFFAOYSA-N 0.000 abstract 2
- 239000002253 acid Substances 0.000 abstract 2
- 229910052784 alkaline earth metal Inorganic materials 0.000 abstract 2
- 238000006243 chemical reaction Methods 0.000 abstract 2
- 125000004029 hydroxymethyl group Chemical group [H]OC([H])([H])* 0.000 abstract 2
- XHXFXVLFKHQFAL-UHFFFAOYSA-N phosphoryl trichloride Chemical compound ClP(Cl)(Cl)=O XHXFXVLFKHQFAL-UHFFFAOYSA-N 0.000 abstract 2
- 239000007858 starting material Substances 0.000 abstract 2
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 abstract 1
- JLTDJTHDQAWBAV-UHFFFAOYSA-N N,N-dimethylaniline Chemical compound CN(C)C1=CC=CC=C1 JLTDJTHDQAWBAV-UHFFFAOYSA-N 0.000 abstract 1
- 125000002777 acetyl group Chemical group [H]C([H])([H])C(*)=O 0.000 abstract 1
- 230000002378 acidificating effect Effects 0.000 abstract 1
- 238000005917 acylation reaction Methods 0.000 abstract 1
- 125000005042 acyloxymethyl group Chemical group 0.000 abstract 1
- 150000001342 alkaline earth metals Chemical class 0.000 abstract 1
- 229910021529 ammonia Inorganic materials 0.000 abstract 1
- 125000003236 benzoyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C(*)=O 0.000 abstract 1
- 229910000019 calcium carbonate Inorganic materials 0.000 abstract 1
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 abstract 1
- 239000003054 catalyst Substances 0.000 abstract 1
- 239000003153 chemical reaction reagent Substances 0.000 abstract 1
- 239000003795 chemical substances by application Substances 0.000 abstract 1
- 125000005982 diphenylmethyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])(*)C1=C([H])C([H])=C([H])C([H])=C1[H] 0.000 abstract 1
- 230000032050 esterification Effects 0.000 abstract 1
- 238000005886 esterification reaction Methods 0.000 abstract 1
- 235000019253 formic acid Nutrition 0.000 abstract 1
- 150000004674 formic acids Chemical class 0.000 abstract 1
- 125000000524 functional group Chemical group 0.000 abstract 1
- 150000004820 halides Chemical class 0.000 abstract 1
- 230000003301 hydrolyzing effect Effects 0.000 abstract 1
- 239000000543 intermediate Substances 0.000 abstract 1
- OHZZTXYKLXZFSZ-UHFFFAOYSA-I manganese(3+) 5,10,15-tris(1-methylpyridin-1-ium-4-yl)-20-(1-methylpyridin-4-ylidene)porphyrin-22-ide pentachloride Chemical compound [Cl-].[Cl-].[Cl-].[Cl-].[Cl-].[Mn+3].C1=CN(C)C=CC1=C1C(C=C2)=NC2=C(C=2C=C[N+](C)=CC=2)C([N-]2)=CC=C2C(C=2C=C[N+](C)=CC=2)=C(C=C2)N=C2C(C=2C=C[N+](C)=CC=2)=C2N=C1C=C2 OHZZTXYKLXZFSZ-UHFFFAOYSA-I 0.000 abstract 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 abstract 1
- 239000012038 nucleophile Substances 0.000 abstract 1
- 239000003960 organic solvent Substances 0.000 abstract 1
- 235000011007 phosphoric acid Nutrition 0.000 abstract 1
- 150000003016 phosphoric acids Chemical class 0.000 abstract 1
- 150000003017 phosphorus Chemical class 0.000 abstract 1
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 abstract 1
- UMJSCPRVCHMLSP-UHFFFAOYSA-N pyridine Natural products COC1=CC=CN=C1 UMJSCPRVCHMLSP-UHFFFAOYSA-N 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 125000003808 silyl group Chemical group [H][Si]([H])([H])[*] 0.000 abstract 1
- 125000000999 tert-butyl group Chemical group [H]C([H])([H])C(*)(C([H])([H])[H])C([H])([H])[H] 0.000 abstract 1
- 150000003512 tertiary amines Chemical class 0.000 abstract 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C29/00—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring
- C07C29/48—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring by oxidation reactions with formation of hydroxy groups
- C07C29/50—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring by oxidation reactions with formation of hydroxy groups with molecular oxygen only
- C07C29/54—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring by oxidation reactions with formation of hydroxy groups with molecular oxygen only starting from compounds containing carbon-to-metal bonds and followed by conversion of the -O- metal to -OH groups
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12C—BEER; PREPARATION OF BEER BY FERMENTATION; PREPARATION OF MALT FOR MAKING BEER; PREPARATION OF HOPS FOR MAKING BEER
- C12C11/00—Fermentation processes for beer
- C12C11/02—Pitching yeast
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- General Engineering & Computer Science (AREA)
- Microbiology (AREA)
- Food Science & Technology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Biochemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Mycology (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Cephalosporin Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Priority Applications (13)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB3849267A GB1241655A (en) | 1967-08-21 | 1967-08-21 | Improvements in or relating to cephalosporin compounds |
| GB3849268D GB1208515A (en) | 1967-08-21 | 1968-08-12 | Alkylaluminium oxidation process |
| AT811568A AT303956B (de) | 1967-08-21 | 1968-08-20 | Verfahren zur Herstellung von Verbindungen der Cephalosporinreihe |
| BE719712A BE719712A (cg-RX-API-DMAC7.html) | 1967-08-21 | 1968-08-20 | |
| DE19681795178 DE1795178A1 (de) | 1967-08-21 | 1968-08-20 | Verfahren zur Herstellung von Verbindungen der Cephalosporinreihe |
| CH1251268A CH553816A (de) | 1967-08-21 | 1968-08-20 | Verfahren zur herstellung von n-deacylierten cephalosporinverbindungen. |
| IE102168A IE32915B1 (en) | 1967-08-21 | 1968-08-20 | Improvements in or relating to cephalosporin compounds |
| IL3058168A IL30581A (en) | 1967-08-21 | 1968-08-20 | Preparation of 7-amino cephalosporanic acid |
| FR1585971D FR1585971A (cg-RX-API-DMAC7.html) | 1967-08-21 | 1968-08-20 | |
| JP5910668A JPS5437157B1 (cg-RX-API-DMAC7.html) | 1967-08-21 | 1968-08-20 | |
| NL6811828A NL6811828A (cg-RX-API-DMAC7.html) | 1967-08-21 | 1968-08-20 | |
| CA027932A CA924302A (en) | 1967-08-21 | 1968-08-20 | Cephalosporin compounds |
| PH9489*UA PH9433A (en) | 1967-08-21 | 1968-08-21 | Process for the preparation of 7-aminocephalosporins and acid addition salts thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB3849267A GB1241655A (en) | 1967-08-21 | 1967-08-21 | Improvements in or relating to cephalosporin compounds |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB1241655A true GB1241655A (en) | 1971-08-04 |
Family
ID=10403818
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB3849267A Expired GB1241655A (en) | 1967-08-21 | 1967-08-21 | Improvements in or relating to cephalosporin compounds |
| GB3849268D Expired GB1208515A (en) | 1967-08-21 | 1968-08-12 | Alkylaluminium oxidation process |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB3849268D Expired GB1208515A (en) | 1967-08-21 | 1968-08-12 | Alkylaluminium oxidation process |
Country Status (11)
| Country | Link |
|---|---|
| JP (1) | JPS5437157B1 (cg-RX-API-DMAC7.html) |
| AT (1) | AT303956B (cg-RX-API-DMAC7.html) |
| BE (1) | BE719712A (cg-RX-API-DMAC7.html) |
| CA (1) | CA924302A (cg-RX-API-DMAC7.html) |
| CH (1) | CH553816A (cg-RX-API-DMAC7.html) |
| DE (1) | DE1795178A1 (cg-RX-API-DMAC7.html) |
| FR (1) | FR1585971A (cg-RX-API-DMAC7.html) |
| GB (2) | GB1241655A (cg-RX-API-DMAC7.html) |
| IL (1) | IL30581A (cg-RX-API-DMAC7.html) |
| NL (1) | NL6811828A (cg-RX-API-DMAC7.html) |
| PH (1) | PH9433A (cg-RX-API-DMAC7.html) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4562253A (en) * | 1982-08-06 | 1985-12-31 | Biochemie Gesellschaft M.B.H. | Deacylation of amides |
| US6005101A (en) * | 1994-07-22 | 1999-12-21 | Antibioticos S.P.A. | Glutaryl 7-ACA derivatives and processes for obtaining them |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB1385683A (en) * | 1971-03-01 | 1975-02-26 | Glaxo Lab Ltd | Antibiotics |
| GB1385685A (en) * | 1971-04-21 | 1975-02-26 | Glaxo Lab Ltd | Cephalosporin derivatives |
| GB1391271A (en) * | 1971-04-30 | 1975-04-16 | Glaxo Lab Ltd | Preparation of antibiotic compounds |
-
1967
- 1967-08-21 GB GB3849267A patent/GB1241655A/en not_active Expired
-
1968
- 1968-08-12 GB GB3849268D patent/GB1208515A/en not_active Expired
- 1968-08-20 CH CH1251268A patent/CH553816A/xx not_active IP Right Cessation
- 1968-08-20 DE DE19681795178 patent/DE1795178A1/de active Pending
- 1968-08-20 FR FR1585971D patent/FR1585971A/fr not_active Expired
- 1968-08-20 JP JP5910668A patent/JPS5437157B1/ja active Pending
- 1968-08-20 AT AT811568A patent/AT303956B/de not_active IP Right Cessation
- 1968-08-20 IL IL3058168A patent/IL30581A/xx unknown
- 1968-08-20 NL NL6811828A patent/NL6811828A/xx unknown
- 1968-08-20 CA CA027932A patent/CA924302A/en not_active Expired
- 1968-08-20 BE BE719712A patent/BE719712A/xx unknown
- 1968-08-21 PH PH9489*UA patent/PH9433A/en unknown
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4562253A (en) * | 1982-08-06 | 1985-12-31 | Biochemie Gesellschaft M.B.H. | Deacylation of amides |
| US6005101A (en) * | 1994-07-22 | 1999-12-21 | Antibioticos S.P.A. | Glutaryl 7-ACA derivatives and processes for obtaining them |
Also Published As
| Publication number | Publication date |
|---|---|
| FR1585971A (cg-RX-API-DMAC7.html) | 1970-02-06 |
| BE719712A (cg-RX-API-DMAC7.html) | 1969-02-20 |
| AT303956B (de) | 1972-12-27 |
| JPS5437157B1 (cg-RX-API-DMAC7.html) | 1979-11-13 |
| GB1208515A (en) | 1970-10-14 |
| PH9433A (en) | 1975-11-26 |
| DE1795178A1 (de) | 1972-08-10 |
| IL30581A (en) | 1975-05-22 |
| CA924302A (en) | 1973-04-10 |
| NL6811828A (cg-RX-API-DMAC7.html) | 1969-02-25 |
| CH553816A (de) | 1974-09-13 |
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