GB1240943A - BASIC alpha-NORTRICYCLYL-(3)-BENZYL ETHERS AND SALTS, QUATERNARY AMMONIUM SALTS AND N-OXIDES THEREOF, PROCESSES FOR THE PRODUCTION THEREOF, AND PHARMACEUTICAL COMPOSITIONS CONTAINING THE SAME - Google Patents
BASIC alpha-NORTRICYCLYL-(3)-BENZYL ETHERS AND SALTS, QUATERNARY AMMONIUM SALTS AND N-OXIDES THEREOF, PROCESSES FOR THE PRODUCTION THEREOF, AND PHARMACEUTICAL COMPOSITIONS CONTAINING THE SAMEInfo
- Publication number
- GB1240943A GB1240943A GB43518/69A GB4351869A GB1240943A GB 1240943 A GB1240943 A GB 1240943A GB 43518/69 A GB43518/69 A GB 43518/69A GB 4351869 A GB4351869 A GB 4351869A GB 1240943 A GB1240943 A GB 1240943A
- Authority
- GB
- United Kingdom
- Prior art keywords
- quaternary ammonium
- salts
- alkyl
- oxides
- halogen
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 150000003242 quaternary ammonium salts Chemical class 0.000 title abstract 3
- 239000008194 pharmaceutical composition Substances 0.000 title 1
- 150000003839 salts Chemical class 0.000 title 1
- 239000002253 acid Substances 0.000 abstract 3
- 125000000217 alkyl group Chemical group 0.000 abstract 3
- 150000001875 compounds Chemical class 0.000 abstract 3
- 229910052736 halogen Inorganic materials 0.000 abstract 3
- 150000001204 N-oxides Chemical class 0.000 abstract 2
- 238000006243 chemical reaction Methods 0.000 abstract 2
- 150000002367 halogens Chemical class 0.000 abstract 2
- 125000004970 halomethyl group Chemical group 0.000 abstract 2
- 125000004214 1-pyrrolidinyl group Chemical group [H]C1([H])N(*)C([H])([H])C([H])([H])C1([H])[H] 0.000 abstract 1
- 206010044565 Tremor Diseases 0.000 abstract 1
- 125000003545 alkoxy group Chemical group 0.000 abstract 1
- HSFWRNGVRCDJHI-UHFFFAOYSA-N alpha-acetylene Natural products C#C HSFWRNGVRCDJHI-UHFFFAOYSA-N 0.000 abstract 1
- 230000003266 anti-allergic effect Effects 0.000 abstract 1
- 239000000043 antiallergic agent Substances 0.000 abstract 1
- 239000000935 antidepressant agent Substances 0.000 abstract 1
- 229940005513 antidepressants Drugs 0.000 abstract 1
- 239000011230 binding agent Substances 0.000 abstract 1
- 230000015572 biosynthetic process Effects 0.000 abstract 1
- 150000002170 ethers Chemical class 0.000 abstract 1
- 125000002534 ethynyl group Chemical group [H]C#C* 0.000 abstract 1
- 125000005843 halogen group Chemical group 0.000 abstract 1
- 239000003112 inhibitor Substances 0.000 abstract 1
- 239000000825 pharmaceutical preparation Substances 0.000 abstract 1
- -1 piperidino, morpholino Chemical group 0.000 abstract 1
- 230000002048 spasmolytic effect Effects 0.000 abstract 1
- 150000003512 tertiary amines Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D207/08—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon radicals, substituted by hetero atoms, attached to ring carbon atoms
- C07D207/09—Radicals substituted by nitrogen atoms, not forming part of a nitro radical
Abstract
1,240,943. Basic ethers. ASTA-WERKE A.G. 3 Sept., 1969 [6 Sept., 1968], No. 43518/69. Headings C2C. Compounds of the general formula (R 1 = H, halogen, CF 3 , C 1 _ 4 alkyl or alkoxy; R 2 = H, C 1 _ 4 alkyl, ethynyl; alk=CH 2 , CH 2 CH 2 , CH(CH 3 ); A=CHR 6 NR 3 R 4 ; R 3 , 4 = C 1 _ 4 alkyl or NR 3 R 4 = 1-pyrrolidinyl, piperidino, morpholino; R 6 = H, Me, Et; or A= 1-(C 1 _ 4 alkyl)- pyrrolidinyl-(2) or -(3)), their N-oxides and acid addition and quaternary ammonium salts thereof are prepared by reacting a compound of the formula with Y-alk-A 1 (X=halogen, Y=OH or X = OH, Y = halogen; A 1 = A or halomethyl) in the presence of an acid binding agent at an elevated temperature, followed by reaction with R 3 R 4 NH when A 1 = halomethyl and optionally followed by conversion to the N-oxide and/or acid addition or quaternary ammonium salt formation. The above compounds are spasmolytics and the tertiary amines are antiallergics, antidepressants and tremor inhibitors. They may be administered in the form of pharmaceutical preparations containing them in association with a carrier.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE19681793364 DE1793364A1 (en) | 1968-09-06 | 1968-09-06 | Basic alpha-nortricyclyl- (3) -benzyl-ethers, their quaternary salts and N-oxides and pharmaceutical products made therefrom |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB1240943A true GB1240943A (en) | 1971-07-28 |
Family
ID=5707679
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB43518/69A Expired GB1240943A (en) | 1968-09-06 | 1969-09-03 | BASIC alpha-NORTRICYCLYL-(3)-BENZYL ETHERS AND SALTS, QUATERNARY AMMONIUM SALTS AND N-OXIDES THEREOF, PROCESSES FOR THE PRODUCTION THEREOF, AND PHARMACEUTICAL COMPOSITIONS CONTAINING THE SAME |
Country Status (13)
| Country | Link |
|---|---|
| US (1) | US3686311A (en) |
| AT (1) | AT296249B (en) |
| BE (1) | BE738449A (en) |
| BR (1) | BR6912200D0 (en) |
| CH (1) | CH545767A (en) |
| DE (1) | DE1793364A1 (en) |
| ES (1) | ES370977A1 (en) |
| FR (1) | FR2017501A1 (en) |
| GB (1) | GB1240943A (en) |
| IL (1) | IL32882A0 (en) |
| LU (1) | LU59333A1 (en) |
| NL (1) | NL6913584A (en) |
| OA (1) | OA03379A (en) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE2413814C3 (en) * | 1974-03-22 | 1979-10-04 | Asta-Werke Ag Chemische Fabrik, 4800 Bielefeld | Aminoalkyl ethers of aryl (tricycloheptylidene) methanes and their salts, manufacturing processes and drugs |
| US4124716A (en) * | 1974-03-22 | 1978-11-07 | Asta-Werke Aktiengesellschaft | Process for the treatment of spasmodic conditions in humans |
| DE102004045220A1 (en) * | 2004-09-17 | 2006-04-06 | Riemser Arzneimittel Ag | New medicines |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2812327A (en) * | 1954-04-14 | 1957-11-05 | Thomae Gmbh Dr K | Basic ethers of carbinols substituted by endocyclic groups, and a process of making same |
| US2914561A (en) * | 1957-08-06 | 1959-11-24 | Wm S Merrell Co | Amine derivatives of triphenylethylene |
| DE1102156B (en) * | 1959-02-27 | 1961-03-16 | Bayer Ag | Process for the preparation of basic substituted esters of hydracrylic acid |
| US2971001A (en) * | 1959-10-21 | 1961-02-07 | Wm S Merrell Co | Quaternary salts of triphenylethanols, -ethylenes, and -ethanes |
-
1968
- 1968-09-06 DE DE19681793364 patent/DE1793364A1/en active Pending
-
1969
- 1969-08-21 US US857272A patent/US3686311A/en not_active Expired - Lifetime
- 1969-08-21 AT AT802669A patent/AT296249B/en not_active IP Right Cessation
- 1969-08-21 LU LU59333D patent/LU59333A1/xx unknown
- 1969-08-22 IL IL32882A patent/IL32882A0/en unknown
- 1969-08-29 ES ES370977A patent/ES370977A1/en not_active Expired
- 1969-09-02 CH CH1327669A patent/CH545767A/xx not_active IP Right Cessation
- 1969-09-03 GB GB43518/69A patent/GB1240943A/en not_active Expired
- 1969-09-04 FR FR6930160A patent/FR2017501A1/fr not_active Withdrawn
- 1969-09-05 NL NL6913584A patent/NL6913584A/xx unknown
- 1969-09-05 BR BR212200/69A patent/BR6912200D0/en unknown
- 1969-09-05 BE BE738449D patent/BE738449A/xx unknown
- 1969-09-06 OA OA53723A patent/OA03379A/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| BE738449A (en) | 1970-02-16 |
| IL32882A0 (en) | 1970-01-29 |
| CH545767A (en) | 1974-02-15 |
| DE1793364A1 (en) | 1972-01-27 |
| AT296249B (en) | 1972-02-10 |
| ES370977A1 (en) | 1972-01-01 |
| US3686311A (en) | 1972-08-22 |
| OA03379A (en) | 1970-12-15 |
| BR6912200D0 (en) | 1973-05-10 |
| SU375844A3 (en) | 1973-03-23 |
| FR2017501A1 (en) | 1970-05-22 |
| NL6913584A (en) | 1970-03-10 |
| LU59333A1 (en) | 1970-01-06 |
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