GB1240786A - Process of manufacturing radioactive substances derived from difluorescenylmercury and labelled with radioactive iodin isotopes - Google Patents
Process of manufacturing radioactive substances derived from difluorescenylmercury and labelled with radioactive iodin isotopesInfo
- Publication number
- GB1240786A GB1240786A GB60432/69A GB6043269A GB1240786A GB 1240786 A GB1240786 A GB 1240786A GB 60432/69 A GB60432/69 A GB 60432/69A GB 6043269 A GB6043269 A GB 6043269A GB 1240786 A GB1240786 A GB 1240786A
- Authority
- GB
- United Kingdom
- Prior art keywords
- mercury
- radioactive
- compounds
- compound
- bis
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
- C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
- C07D493/10—Spiro-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Epidemiology (AREA)
- Optics & Photonics (AREA)
- Pharmacology & Pharmacy (AREA)
- Physics & Mathematics (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Abstract
1,240,786. Radioactive difluoresceinyl-mercury compounds. CESKOSLOVENSKA AKADEMIE VEB. 11 Dec., 1969 [20 Dec., 1968], No. 60432/69. Heading C2J. In difluoresceinyl-mercury compounds of Formalµ (Ia) or (Ib) (where R=H or halogen and R<SP>1</SP>-R<SP>5</SP> = H, halogen, alkyl or HgX, where X is an anion) at least one of R and R<SP>1</SP>-R<SP>5</SP> is radioactive iodine. The mercury atom need not be radioactive. The compounds may be prepared by reacting a suspension of the corresponding fluorescein derivative with a solution of an ionic bivalent mercury compound, e.g. mercuric acetate, whereby the mercury atom is substituted in two stages. The desired compound is separated by chromatography. The following compounds are disclosed, having labelling <SP>125</SP>I, <SP>131</SP>I, <SP>125</SP>I<SP>203</SP>Hg, <SP>125</SP>I<SP>197</SP>Hg, <SP>131</SP>I<SP>203</SP>Hg or <SP>131</SP>I<SP>197</SP>Hg: bis-4<SP>1</SP>-(2<SP>1</SP>,7<SP>1</SP>-diiodofluoresceinyl) mercury, bis - 21 - (4<SP>1</SP>,5<SP>1</SP>- diiodofluoresceinyl) mercury and bis-(tetraiodofluoresceinyl) mercury. The chromatographic fractions can contain the pure compound or a mixture thereof with the hydroxymercuryfluorescein compound.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CS866368 | 1968-12-20 |
Publications (1)
Publication Number | Publication Date |
---|---|
GB1240786A true GB1240786A (en) | 1971-07-28 |
Family
ID=5437489
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
GB60432/69A Expired GB1240786A (en) | 1968-12-20 | 1969-12-11 | Process of manufacturing radioactive substances derived from difluorescenylmercury and labelled with radioactive iodin isotopes |
Country Status (8)
Country | Link |
---|---|
BE (1) | BE743230A (en) |
BR (1) | BR6915452D0 (en) |
DE (1) | DE1964100A1 (en) |
ES (1) | ES374647A1 (en) |
FR (1) | FR2104724B1 (en) |
GB (1) | GB1240786A (en) |
NL (1) | NL6918943A (en) |
ZA (1) | ZA698810B (en) |
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2008003954A1 (en) * | 2006-07-05 | 2008-01-10 | Ge Healthcare Limited | Dye imaging agents |
CN113702342A (en) * | 2021-04-21 | 2021-11-26 | 苏州科技大学 | Method for detecting mercury ions in solution by fluorescence conversion |
-
1969
- 1969-12-11 GB GB60432/69A patent/GB1240786A/en not_active Expired
- 1969-12-16 BE BE743230D patent/BE743230A/xx unknown
- 1969-12-17 NL NL6918943A patent/NL6918943A/xx unknown
- 1969-12-17 ES ES374647A patent/ES374647A1/en not_active Expired
- 1969-12-18 FR FR6943861A patent/FR2104724B1/fr not_active Expired
- 1969-12-19 ZA ZA698810*A patent/ZA698810B/en unknown
- 1969-12-19 BR BR215452/69A patent/BR6915452D0/en unknown
- 1969-12-22 DE DE19691964100 patent/DE1964100A1/en active Pending
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2008003954A1 (en) * | 2006-07-05 | 2008-01-10 | Ge Healthcare Limited | Dye imaging agents |
CN113702342A (en) * | 2021-04-21 | 2021-11-26 | 苏州科技大学 | Method for detecting mercury ions in solution by fluorescence conversion |
Also Published As
Publication number | Publication date |
---|---|
ZA698810B (en) | 1971-08-25 |
DE1964100A1 (en) | 1970-07-02 |
BE743230A (en) | 1970-05-28 |
NL6918943A (en) | 1970-06-23 |
FR2104724A1 (en) | 1972-04-21 |
ES374647A1 (en) | 1972-01-01 |
BR6915452D0 (en) | 1973-05-15 |
FR2104724B1 (en) | 1975-01-10 |
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