GB1221597A - Novel mercury derivatives of the fluorescein series tagged with radioactive iodine isotopes, and a process of preparing same - Google Patents

Novel mercury derivatives of the fluorescein series tagged with radioactive iodine isotopes, and a process of preparing same

Info

Publication number
GB1221597A
GB1221597A GB5772468A GB5772468A GB1221597A GB 1221597 A GB1221597 A GB 1221597A GB 5772468 A GB5772468 A GB 5772468A GB 5772468 A GB5772468 A GB 5772468A GB 1221597 A GB1221597 A GB 1221597A
Authority
GB
United Kingdom
Prior art keywords
hydroxymercury
diiodofluorescein
hydrogen
radioactive
mercury
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB5772468A
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Czech Academy of Sciences CAS
Original Assignee
Czech Academy of Sciences CAS
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Czech Academy of Sciences CAS filed Critical Czech Academy of Sciences CAS
Publication of GB1221597A publication Critical patent/GB1221597A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B59/00—Introduction of isotopes of elements into organic compounds ; Labelled organic compounds per se
    • C07B59/004—Acyclic, carbocyclic or heterocyclic compounds containing elements other than carbon, hydrogen, halogen, oxygen, nitrogen, sulfur, selenium or tellurium
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • C—CHEMISTRY; METALLURGY
    • C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
    • C09B—ORGANIC DYES OR CLOSELY-RELATED COMPOUNDS FOR PRODUCING DYES, e.g. PIGMENTS; MORDANTS; LAKES
    • C09B11/00—Diaryl- or thriarylmethane dyes
    • C09B11/04—Diaryl- or thriarylmethane dyes derived from triarylmethanes, i.e. central C-atom is substituted by amino, cyano, alkyl
    • C09B11/06—Hydroxy derivatives of triarylmethanes in which at least one OH group is bound to an aryl nucleus and their ethers or esters
    • C09B11/08—Phthaleins; Phenolphthaleins; Fluorescein
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2123/00—Preparations for testing in vivo

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Physics & Mathematics (AREA)
  • Medicinal Chemistry (AREA)
  • Optics & Photonics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)

Abstract

1,221,597. Radioactive iodine labelled mercury derivatives of fluorescein. CESKOSLOVENSKA AKADEMIE VED. 5 Dec., 1968 [7 Dec., 1967], No. 57724/68. Heading C2J. A mercury derivative of the fluorescein series is prepared by treating with a bivalent mercury compound a compound of the general formula wherein R is a hydrogen atom or a halogen atom; R<SP>1</SP>, R<SP>2</SP>, R<SP>3</SP>, R<SP>4</SP>, R<SP>5</SP> and R<SP>6</SP> are hydrogen, halogen, alkyl residues having one to five carbon atoms or N(R<SP>7</SP>) 2 residues, where R<SP>7</SP> is hydrogen or an alkyl residue having one to five carbon atoms; and wherein at least one of the substituents R, R<SP>1</SP>, R<SP>2</SP>, R<SP>3</SP>, R<SP>4</SP>, R<SP>5</SP> and R<SP>6</SP> is a radioactive iodine atom; and wherein at least one of the substituents R<SP>1</SP>, R<SP>2</SP>, R<SP>3</SP>, R<SP>4</SP>, R<SP>5</SP> and R<SP>6</SP> is hydrogen. The iodine isotope used may be <SP>131</SP>I or <SP>125</SP>I. and the mercuric compound may be non-radioactive or contain the radioactive mercury isotopes <SP>203</SP>Hg or <SP>197</SP>Hg. Specified products of the invention are:-4<SP>1</SP>-hydroxymercury-2<SP>1</SP>,7<SP>1</SP>-diiodofluorescein; bis-hydroxymercury - 2<SP>1</SP>,7<SP>1</SP> - diiodofluorescein; dichloro-4<SP>1</SP>- hydroxymercury - 2<SP>1</SP>,7<SP>1</SP> - diiodofluorescein; diiodo - 4<SP>1</SP> - hydroxymercury - 2<SP>1</SP>,7<SP>1</SP> - dibromofluorescein; 2<SP>1</SP> - hydroxymercury - 2<SP>1</SP>,5<SP>1</SP> - diiodofluorescein; and bis-(hydroxymercury) - 4<SP>1</SP>,5<SP>1</SP>- diiodofluorescein. Each of these may be labelled with <SP>125</SP>I, or <SP>131</SP>I, or <SP>125</SP>I<SP>203</SP>Hg, or <SP>125</SP>I- <SP>197</SP>Hg, or <SP>131</SP>I<SP>203</SP>Hg, or <SP>131</SP>I<SP>197</SP>Hg.
GB5772468A 1967-12-07 1968-12-05 Novel mercury derivatives of the fluorescein series tagged with radioactive iodine isotopes, and a process of preparing same Expired GB1221597A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CS869467 1967-12-07

Publications (1)

Publication Number Publication Date
GB1221597A true GB1221597A (en) 1971-02-03

Family

ID=5437870

Family Applications (1)

Application Number Title Priority Date Filing Date
GB5772468A Expired GB1221597A (en) 1967-12-07 1968-12-05 Novel mercury derivatives of the fluorescein series tagged with radioactive iodine isotopes, and a process of preparing same

Country Status (9)

Country Link
BE (1) BE724644A (en)
BR (1) BR6804686D0 (en)
CA (1) CA933918A (en)
CH (1) CH507294A (en)
DE (1) DE1813150A1 (en)
ES (1) ES361154A1 (en)
FR (1) FR1601339A (en)
GB (1) GB1221597A (en)
NL (1) NL6817291A (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8852552B2 (en) 2010-11-15 2014-10-07 Biopercept Ab Agents and methods for visualizing analytes

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NO884565L (en) * 1987-10-15 1989-04-17 Univ Moskovsk PREPARATION FOR DISPOSITION OF DIAGNOSIS OF DEPARTURED NEOPLASMA.

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8852552B2 (en) 2010-11-15 2014-10-07 Biopercept Ab Agents and methods for visualizing analytes

Also Published As

Publication number Publication date
CH507294A (en) 1971-05-15
BE724644A (en) 1969-05-02
FR1601339A (en) 1970-08-17
BR6804686D0 (en) 1973-03-08
ES361154A1 (en) 1970-12-16
NL6817291A (en) 1969-06-10
DE1813150A1 (en) 1969-06-19
CA933918A (en) 1973-09-18

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