GB1232469A - - Google Patents

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Publication number
GB1232469A
GB1232469A GB1232469DA GB1232469A GB 1232469 A GB1232469 A GB 1232469A GB 1232469D A GB1232469D A GB 1232469DA GB 1232469 A GB1232469 A GB 1232469A
Authority
GB
United Kingdom
Prior art keywords
chloro
hydrogen
compounds
fluorine
fluoro
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed filed Critical
Publication of GB1232469A publication Critical patent/GB1232469A/en
Expired legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C51/00—Preparation of carboxylic acids or their salts, halides or anhydrides
    • C07C51/15—Preparation of carboxylic acids or their salts, halides or anhydrides by reaction of organic compounds with carbon dioxide, e.g. Kolbe-Schmitt synthesis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C17/00—Preparation of halogenated hydrocarbons
    • C07C17/093—Preparation of halogenated hydrocarbons by replacement by halogens
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/45—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by condensation
    • C07C45/46—Friedel-Crafts reactions
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C49/00—Ketones; Ketenes; Dimeric ketenes; Ketonic chelates
    • C07C49/76—Ketones containing a keto group bound to a six-membered aromatic ring
    • C07C49/80—Ketones containing a keto group bound to a six-membered aromatic ring containing halogen
    • C07C49/813—Ketones containing a keto group bound to a six-membered aromatic ring containing halogen polycyclic
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C51/00—Preparation of carboxylic acids or their salts, halides or anhydrides
    • C07C51/16—Preparation of carboxylic acids or their salts, halides or anhydrides by oxidation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems

Abstract

1,232,469. Imidazo-isoindoles. SANDOZ Ltd. 14 Aug., 1968 [15 Aug., 1967; 3 May, 1968], No. 38930/68. Addition to 1,225,411. Heading C2C. Novel compounds have the Formula (III) in which R, R 1 and R 2 signify hydrogen, chlorine, fluorine trifluoromethyl, a straight-chain alkyl radical of 1 to 4 carbon atoms or a straightchain alkoxy radical of 1 to 4 carbon atoms, provided that (1) R, R 1 and R 2 are such that there is never trifluoromethyl on each of two adjacent carbon atoms, and (2) when R or R 2 is trifluoromethyl, R 1 is hydrogen, chlorine or fluorine, R 3 , R 4 and R 5 signify hydrogen, chlorine or fluorine, and R 6 is hydrogen or fluorine, with the further provisos that not more than 2 of R 3 , R 4 , R 5 and R 6 are other than hydrogen, and not more than 3 of R, R 1 , R 2 , R 3 , R 4 , R 5 and R 6 are other than hydrogen. The compounds are prepared by reducing a compound (II) with lithium aluminium hydride in an inert ether solvent under an inert atmosphere. Compounds (I) are obtained by a process comprising contacting III with air or oxygen. The following starting materials and intermediates are also described and exemplified: 2 - iodo - 4 - and - 5 - chloro - toluenes, 2 - iodo- 4 - fluorotoluene; 5 - fluoro - and 4 - and 5- chloro - o - toluic acids; 2 - methyl - (4,5 - dichloro-, -5-fluoro-, -4,4<SP>1</SP>,5-trichloro-, -4-chloro- and - 5 - chloro) - benzophenones; 2 - benzoyl- (4-chloro-, -5-chloro-, -4-fluoro- and -4,5-dichloro)- benzoic acids, 2 - (p - chlorobenzoyl) - 4,5 - dichlorobenzoic acid, and 2-(3<SP>1</SP>-trifluoromethylbenzoyl) -, 2 - (3<SP>1</SP> - -fluorobenzoyl) - and 2 - (3,5 - dichlorobenzoyl)-benzoic acids. Compounds IV made, e.g. by reacting the benzoic acids with ethylene diamine are converted into compounds II by hydrogenation.
GB1232469D 1967-08-15 1968-08-14 Expired GB1232469A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US66060967A 1967-08-15 1967-08-15
US72653368A 1968-05-03 1968-05-03

Publications (1)

Publication Number Publication Date
GB1232469A true GB1232469A (en) 1971-05-19

Family

ID=27098133

Family Applications (1)

Application Number Title Priority Date Filing Date
GB1232469D Expired GB1232469A (en) 1967-08-15 1968-08-14

Country Status (8)

Country Link
JP (1) JPS4932878B1 (en)
AT (2) AT296974B (en)
CH (1) CH516573A (en)
DE (1) DE1795105A1 (en)
GB (1) GB1232469A (en)
NL (1) NL6811127A (en)
SE (1) SE344948B (en)
SU (2) SU421194A3 (en)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE1770009A1 (en) * 1968-03-20 1972-04-13 American Home Prod Pyrimide and imidazolinyl compounds
JPS5923393U (en) * 1982-07-10 1984-02-14 薩佐　朝子 wet towel holder
EP3366678A1 (en) * 2013-03-14 2018-08-29 Newlink Genetics Corporation Tricyclic compounds as inhibitors of immunosuppression mediated by tryptophan metabolization

Also Published As

Publication number Publication date
SE344948B (en) 1972-05-08
SU404246A3 (en) 1973-10-26
DE1795105A1 (en) 1972-01-20
JPS4932878B1 (en) 1974-09-03
NL6811127A (en) 1969-02-18
SU421194A3 (en) 1974-03-25
CH516573A (en) 1971-12-15
AT316541B (en) 1974-07-10
AT296974B (en) 1972-03-10

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Legal Events

Date Code Title Description
PS Patent sealed