GB1230906A - - Google Patents

Info

Publication number

GB1230906A

GB1230906A GB1230906DA GB1230906A GB 1230906 A GB1230906 A GB 1230906A GB 1230906D A GB1230906D A GB 1230906DA GB 1230906 A GB1230906 A GB 1230906A

Authority

GB

United Kingdom

Prior art keywords

alkyl

siomycin

mono

bis

dihydrosiomycin

Prior art date

1968-07-26

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Expired

Links

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• 125000000217 alkyl group Chemical group 0.000 abstract 4
• AKFVOKPQHFBYCA-KJULAZMPSA-N N-[3-[(3-amino-3-oxoprop-1-en-2-yl)amino]-3-oxoprop-1-en-2-yl]-2-[(1R,8S,11Z,15S,18S,25S,26R,35R,37S,46S,53S,59S)-18-[(2S,3R)-2,3-dihydroxybutan-2-yl]-11-ethylidene-59-hydroxy-8-[(1R)-1-hydroxyethyl]-31-[(1S)-1-hydroxyethyl]-26,46-dimethyl-40,43-dimethylidene-6,9,16,23,28,38,41,44,47-nonaoxo-37-propan-2-yl-27-oxa-3,13,20,56-tetrathia-7,10,17,24,36,39,42,45,48,52,58,61,62,63,64-pentadecazanonacyclo[23.23.9.329,35.12,5.112,15.119,22.154,57.01,53.032,60]tetrahexaconta-2(64),4,12(63),19(62),21,29(61),30,32(60),33,51,54,57-dodecaen-51-yl]-1,3-thiazole-4-carboxamide Chemical class C/C=C\1/C2=N[C@H](CS2)C(=O)N[C@H](C3=NC(=CS3)C(=O)N[C@H]4[C@H](OC(=O)C5=NC6=C(C=C[C@H]([C@@H]6O)N[C@H](C(=O)NC(=C)C(=O)NC(=C)C(=O)N[C@H](C(=O)N[C@@]7(CCC(=N[C@@H]7C8=CSC4=N8)C9=NC(=CS9)C(=O)NC(=C)C(=O)NC(=C)C(=O)N)C2=NC(=CS2)C(=O)N[C@H](C(=O)N1)[C@@H](C)O)C)C(C)C)C(=C5)[C@H](C)O)C)[C@@](C)([C@@H](C)O)O AKFVOKPQHFBYCA-KJULAZMPSA-N 0.000 abstract 3
• 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 abstract 3
• 230000000844 anti-bacterial effect Effects 0.000 abstract 2
• 229910052739 hydrogen Inorganic materials 0.000 abstract 2
• 239000001257 hydrogen Substances 0.000 abstract 2
• 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 2
• 239000000203 mixture Substances 0.000 abstract 2
• AKFVOKPQHFBYCA-UHFFFAOYSA-N (1-L-valine)-[2-(2,3-didehydro-alanine)]-thiostrepton Natural products N=1C2C(N=3)=CSC=3C(C(C)OC(=O)C=3N=C4C(O)C(NC(C(C)C)C(=O)NC(=C)C(=O)NC(=C)C(=O)NC(C)C(=O)N5)C=CC4=C(C(C)O)C=3)NC(=O)C(N=3)=CSC=3C(C(C)(O)C(C)O)NC(=O)C(N=3)CSC=3C(=CC)NC(=O)C(C(C)O)NC(=O)C(N=3)=CSC=3C25CCC=1C1=NC(C(=O)NC(=C)C(=O)NC(=C)C(N)=O)=CS1 AKFVOKPQHFBYCA-UHFFFAOYSA-N 0.000 abstract 1
• STTJBBWRTRUGII-UHFFFAOYSA-N Siomycin A Natural products CC=C1/NC(=O)C(NC(=O)c2csc(n2)C34CCC(=NC3c5csc(n5)C(NC(=O)c6csc(n6)C(NC(=O)C7CSC1=N7)C(C)(O)C(C)O)C(C)OC(=O)c8cc(C(C)O)c9C=CC(NC(C(C)C)C(=O)NC(=C)C(=O)NC(=C)C(=O)NC(C)C(=O)N4)C(O)c9n8)c%10nc(cs%10)C(=O)N)C(C)O STTJBBWRTRUGII-UHFFFAOYSA-N 0.000 abstract 1
• 229910052783 alkali metal Inorganic materials 0.000 abstract 1
• 150000001340 alkali metals Chemical class 0.000 abstract 1
• 229910052784 alkaline earth metal Inorganic materials 0.000 abstract 1
• 150000001342 alkaline earth metals Chemical class 0.000 abstract 1
• 125000002947 alkylene group Chemical group 0.000 abstract 1
• -1 amino, hydroxy, carboxyl Chemical group 0.000 abstract 1
• 150000003863 ammonium salts Chemical class 0.000 abstract 1
• 230000003115 biocidal effect Effects 0.000 abstract 1
• 125000004432 carbon atom Chemical group C* 0.000 abstract 1
• HDFRDWFLWVCOGP-UHFFFAOYSA-N carbonothioic O,S-acid Chemical compound OC(S)=O HDFRDWFLWVCOGP-UHFFFAOYSA-N 0.000 abstract 1
• 238000004587 chromatography analysis Methods 0.000 abstract 1
• 239000000839 emulsion Substances 0.000 abstract 1
• 239000012442 inert solvent Substances 0.000 abstract 1
• 239000007788 liquid Substances 0.000 abstract 1
• 238000001556 precipitation Methods 0.000 abstract 1
• 238000002360 preparation method Methods 0.000 abstract 1
• 238000001953 recrystallisation Methods 0.000 abstract 1
• 150000003839 salts Chemical class 0.000 abstract 1
• 108010057354 siomycin A Proteins 0.000 abstract 1
• 238000000638 solvent extraction Methods 0.000 abstract 1
• 239000000725 suspension Substances 0.000 abstract 1
• 239000003826 tablet Substances 0.000 abstract 1