GB1209572A - Improvements in or relating to the preparation of (-)-norscopolamine - Google Patents
Improvements in or relating to the preparation of (-)-norscopolamineInfo
- Publication number
- GB1209572A GB1209572A GB03087/69A GB1308769A GB1209572A GB 1209572 A GB1209572 A GB 1209572A GB 03087/69 A GB03087/69 A GB 03087/69A GB 1308769 A GB1308769 A GB 1308769A GB 1209572 A GB1209572 A GB 1209572A
- Authority
- GB
- United Kingdom
- Prior art keywords
- norscopolamine
- relating
- preparation
- march
- acid addition
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 239000002253 acid Substances 0.000 abstract 2
- 150000003839 salts Chemical class 0.000 abstract 2
- STECJAGHUSJQJN-UHFFFAOYSA-N N-Methyl-scopolamin Natural products C1C(C2C3O2)N(C)C3CC1OC(=O)C(CO)C1=CC=CC=C1 STECJAGHUSJQJN-UHFFFAOYSA-N 0.000 abstract 1
- 239000007864 aqueous solution Substances 0.000 abstract 1
- 238000006243 chemical reaction Methods 0.000 abstract 1
- MOYZEMOPQDTDHA-YQYZCKNZSA-N norhyoscine Chemical compound C1([C@H](C(=O)OC2C[C@@H]3N[C@@H]([C@H]4O[C@H]43)C2)CO)=CC=CC=C1 MOYZEMOPQDTDHA-YQYZCKNZSA-N 0.000 abstract 1
- MOYZEMOPQDTDHA-UHFFFAOYSA-N norscopolamine Natural products C1C(C2OC22)NC2CC1OC(=O)C(CO)C1=CC=CC=C1 MOYZEMOPQDTDHA-UHFFFAOYSA-N 0.000 abstract 1
- 238000007067 oxidative demethylation reaction Methods 0.000 abstract 1
- STECJAGHUSJQJN-FWXGHANASA-N scopolamine Chemical compound C1([C@@H](CO)C(=O)O[C@H]2C[C@@H]3N([C@H](C2)[C@@H]2[C@H]3O2)C)=CC=CC=C1 STECJAGHUSJQJN-FWXGHANASA-N 0.000 abstract 1
- 239000000243 solution Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D451/00—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
- C07D451/02—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof
- C07D451/04—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof with hetero atoms directly attached in position 3 of the 8-azabicyclo [3.2.1] octane or in position 7 of the 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring system
- C07D451/06—Oxygen atoms
- C07D451/10—Oxygen atoms acylated by aliphatic or araliphatic carboxylic acids, e.g. atropine, scopolamine
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| AT243968A AT303977B (de) | 1968-03-12 | 1968-03-12 | Verfahren zur Herstellung von (-)-Norscopolamin |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB1209572A true GB1209572A (en) | 1970-10-21 |
Family
ID=3534370
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB03087/69A Expired GB1209572A (en) | 1968-03-12 | 1969-03-12 | Improvements in or relating to the preparation of (-)-norscopolamine |
Country Status (15)
| Country | Link |
|---|---|
| US (1) | US3538102A (https=) |
| JP (1) | JPS4835280B1 (https=) |
| AT (1) | AT303977B (https=) |
| BE (1) | BE729762A (https=) |
| CA (1) | CA947298A (https=) |
| CH (1) | CH505827A (https=) |
| CS (1) | CS150244B2 (https=) |
| DE (1) | DE1912563A1 (https=) |
| DK (1) | DK123599B (https=) |
| FI (1) | FI48928C (https=) |
| FR (1) | FR2003745A1 (https=) |
| GB (1) | GB1209572A (https=) |
| IL (1) | IL31786A (https=) |
| NL (1) | NL159387B (https=) |
| YU (1) | YU32686B (https=) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS62173799U (https=) * | 1986-04-22 | 1987-11-05 |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE1670048C3 (de) * | 1966-01-26 | 1980-09-04 | C.H. Boehringer Sohn, 6507 Ingelheim | Neue Norscopolaminderivate |
-
1968
- 1968-03-12 AT AT243968A patent/AT303977B/de active
-
1969
- 1969-02-20 FI FI690537A patent/FI48928C/fi active
- 1969-03-06 CS CS1650A patent/CS150244B2/cs unknown
- 1969-03-07 YU YU0563/69A patent/YU32686B/xx unknown
- 1969-03-10 US US805830A patent/US3538102A/en not_active Expired - Lifetime
- 1969-03-11 CH CH364069A patent/CH505827A/de not_active IP Right Cessation
- 1969-03-11 DK DK132269AA patent/DK123599B/da unknown
- 1969-03-11 NL NL6903771.A patent/NL159387B/xx not_active IP Right Cessation
- 1969-03-11 JP JP44018104A patent/JPS4835280B1/ja active Pending
- 1969-03-12 BE BE729762D patent/BE729762A/xx not_active IP Right Cessation
- 1969-03-12 DE DE19691912563 patent/DE1912563A1/de active Pending
- 1969-03-12 IL IL31786A patent/IL31786A/xx unknown
- 1969-03-12 FR FR6907003A patent/FR2003745A1/fr active Pending
- 1969-03-12 CA CA45438A patent/CA947298A/en not_active Expired
- 1969-03-12 GB GB03087/69A patent/GB1209572A/en not_active Expired
Also Published As
| Publication number | Publication date |
|---|---|
| FI48928B (https=) | 1974-10-31 |
| IL31786A (en) | 1974-01-14 |
| CH505827A (de) | 1971-04-15 |
| YU32686B (en) | 1975-04-30 |
| CS150244B2 (https=) | 1973-09-04 |
| YU56369A (en) | 1974-10-31 |
| FI48928C (fi) | 1975-02-10 |
| AT303977B (de) | 1972-12-27 |
| BE729762A (https=) | 1969-09-12 |
| NL6903771A (https=) | 1969-09-16 |
| US3538102A (en) | 1970-11-03 |
| IL31786A0 (en) | 1969-05-28 |
| JPS4835280B1 (https=) | 1973-10-26 |
| NL159387B (nl) | 1979-02-15 |
| CA947298A (en) | 1974-05-14 |
| DE1912563A1 (de) | 1969-10-09 |
| DK123599B (da) | 1972-07-10 |
| FR2003745A1 (https=) | 1969-11-14 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PS | Patent sealed [section 19, patents act 1949] |