GB1209556A - Preparation of 1-aroyl-5-dialkylaminoindolylacetic acids - Google Patents

Preparation of 1-aroyl-5-dialkylaminoindolylacetic acids

Info

Publication number
GB1209556A
GB1209556A GB24760/68A GB2476068A GB1209556A GB 1209556 A GB1209556 A GB 1209556A GB 24760/68 A GB24760/68 A GB 24760/68A GB 2476068 A GB2476068 A GB 2476068A GB 1209556 A GB1209556 A GB 1209556A
Authority
GB
United Kingdom
Prior art keywords
acids
dialkylaminoindolylacetic
aroyl
preparation
chlorobenzoyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB24760/68A
Inventor
Meyer Sletzinger
George Gal
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merck and Co Inc
Original Assignee
Merck and Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck and Co Inc filed Critical Merck and Co Inc
Publication of GB1209556A publication Critical patent/GB1209556A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/18—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D209/26—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with an acyl radical attached to the ring nitrogen atom
    • C07D209/28—1-(4-Chlorobenzoyl)-2-methyl-indolyl-3-acetic acid, substituted in position 5 by an oxygen or nitrogen atom; Esters thereof

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Indole Compounds (AREA)

Abstract

1,209,556. 1 - p - Chlorobenzoyl - 2 - methyl - 5 - dialkylamino-3-indolylacetic acids. MERCK & CO. Inc. 23 May, 1968 [27 May, 1967], No. 24760/68. Heading C2C. 1 - p - Chlorobenzoyl - 2 - methyl - 5 - di - (C 1-5 alkyl) amino - 3 - indolylacetic acids are prepared by treating 1 - p - chlorobenzoyl - 2 - methyl-3-indolylacetic acid or a salt thereof with a di-(C 1-5 alkyl) haloamine in the liquid phase and thereafter, when a salt of the starting material is used, acidifying the reaction mixture.
GB24760/68A 1967-05-27 1968-05-23 Preparation of 1-aroyl-5-dialkylaminoindolylacetic acids Expired GB1209556A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CA991615 1967-05-27

Publications (1)

Publication Number Publication Date
GB1209556A true GB1209556A (en) 1970-10-21

Family

ID=4142914

Family Applications (1)

Application Number Title Priority Date Filing Date
GB24760/68A Expired GB1209556A (en) 1967-05-27 1968-05-23 Preparation of 1-aroyl-5-dialkylaminoindolylacetic acids

Country Status (9)

Country Link
BE (1) BE715427A (en)
CH (1) CH495985A (en)
DK (1) DK118079B (en)
ES (1) ES354006A1 (en)
FR (1) FR1566068A (en)
GB (1) GB1209556A (en)
IL (1) IL29978A0 (en)
NL (1) NL6806500A (en)
SE (1) SE329397B (en)

Also Published As

Publication number Publication date
BE715427A (en) 1968-11-20
NL6806500A (en) 1968-11-28
FR1566068A (en) 1969-05-02
ES354006A1 (en) 1970-03-01
IL29978A0 (en) 1968-07-25
DK118079B (en) 1970-07-06
SE329397B (en) 1970-10-12
CH495985A (en) 1970-09-15

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Legal Events

Date Code Title Description
PS Patent sealed [section 19, patents act 1949]
PLNP Patent lapsed through nonpayment of renewal fees