GB1188629A - Therapeutic Compositions and a Process for the Manufacture thereof - Google Patents

Therapeutic Compositions and a Process for the Manufacture thereof

Info

Publication number
GB1188629A
GB1188629A GB34358/68A GB3435868A GB1188629A GB 1188629 A GB1188629 A GB 1188629A GB 34358/68 A GB34358/68 A GB 34358/68A GB 3435868 A GB3435868 A GB 3435868A GB 1188629 A GB1188629 A GB 1188629A
Authority
GB
United Kingdom
Prior art keywords
steroid
copolymers
styrene
cellulose acetate
maleic acid
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB34358/68A
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
F Hoffmann La Roche AG
Original Assignee
F Hoffmann La Roche AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by F Hoffmann La Roche AG filed Critical F Hoffmann La Roche AG
Publication of GB1188629A publication Critical patent/GB1188629A/en
Expired legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
    • A61K9/2806—Coating materials
    • A61K9/2833—Organic macromolecular compounds
    • A61K9/286—Polysaccharides, e.g. gums; Cyclodextrin
    • A61K9/2866—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose

Landscapes

  • Health & Medical Sciences (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)

Abstract

1,188,629. Steroid compositions. F. HOFFMANN-LA ROCHE & CO. A.G. 18 July, 1968 [28 July, 1967], No. 34358/68. Heading A5B. Therapeutic compositions for the treatment of disturbances of the normal hormonal equilibrium, for oral administration, comprise a medicament nucleus containing a sulpho-conjugated neutral steroid (wherein the steroid moiety is a C 21 , C 19 or C 18 steroid) coated with a layer which is resistant to gastric juice but which is capable of dissolution in the intestines. The steroid comprises the sulphates (acidic and mixed salts with ammonium, Na, K and Ca) and sulphatides (esters of acidic sulphates wherein the sulpho group is esterified with a non-toxic pharmaceutically acceptable monovalent or polyvalent alcohol e.g. glycerine, palmityl or stearyl alcohol) of non- phenolic steroids e.g. pregnenolone, desoxycorticosterone, progesterone, dehydro-epi-androsterone, testosterone and 19-nortestosterone. The coating may be composed of any conventional material e.g. keratin, shellac, colophony, cellulose acetate phthalate, cellulose acetate succinate, copolymers of styrene and maleic acid anhydride, copolymers of butyl partial ester of maleic acid with styrene and acrylic acid, copolymers of maleic acid anhydride and vinyl methyl ether and of styrene and methacrylic acid. The example relates to a dragee nucleus containing sodium dehydro-epi-androsterone sulphate coated with cellulose acetate phthalate.
GB34358/68A 1967-07-28 1968-07-18 Therapeutic Compositions and a Process for the Manufacture thereof Expired GB1188629A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CH1075567 1967-07-28

Publications (1)

Publication Number Publication Date
GB1188629A true GB1188629A (en) 1970-04-22

Family

ID=4366476

Family Applications (1)

Application Number Title Priority Date Filing Date
GB34358/68A Expired GB1188629A (en) 1967-07-28 1968-07-18 Therapeutic Compositions and a Process for the Manufacture thereof

Country Status (6)

Country Link
US (1) US3600495A (en)
BE (1) BE718543A (en)
DE (1) DE1767898A1 (en)
FR (1) FR8158M (en)
GB (1) GB1188629A (en)
NL (1) NL6809629A (en)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SE439586B (en) * 1975-09-05 1985-06-24 Kanebo Ltd SET TO PREPARE A STABLE PHARMACEUTICAL DRY PREPARATION OF AN ALKALIMETAL SALT OF DEHYDROEPIANDROSTERON SULPHATE
US5500227A (en) * 1993-11-23 1996-03-19 Euro-Celtique, S.A. Immediate release tablet cores of insoluble drugs having sustained-release coating
US6210714B1 (en) 1993-11-23 2001-04-03 Euro-Celtique S.A. Immediate release tablet cores of acetaminophen having sustained-release coating

Also Published As

Publication number Publication date
US3600495A (en) 1971-08-17
FR8158M (en) 1970-08-24
NL6809629A (en) 1969-01-30
DE1767898A1 (en) 1971-09-30
BE718543A (en) 1969-01-27

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Legal Events

Date Code Title Description
PS Patent sealed [section 19, patents act 1949]
PLNP Patent lapsed through nonpayment of renewal fees