GB1186794A - 2beta,7-Lower-Alkyl-2alpha,3alpha-Epoxy-17-Oxygenated 5alpha-Androstane Derivatives - Google Patents

2beta,7-Lower-Alkyl-2alpha,3alpha-Epoxy-17-Oxygenated 5alpha-Androstane Derivatives

Info

Publication number
GB1186794A
GB1186794A GB08875/68A GB1887568A GB1186794A GB 1186794 A GB1186794 A GB 1186794A GB 08875/68 A GB08875/68 A GB 08875/68A GB 1887568 A GB1887568 A GB 1887568A GB 1186794 A GB1186794 A GB 1186794A
Authority
GB
United Kingdom
Prior art keywords
alkyl
group
epoxy
compounds
2beta
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB08875/68A
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Shionogi and Co Ltd
Original Assignee
Shionogi and Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Shionogi and Co Ltd filed Critical Shionogi and Co Ltd
Publication of GB1186794A publication Critical patent/GB1186794A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J71/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton is condensed with a heterocyclic ring
    • C07J71/0005—Oxygen-containing hetero ring
    • C07J71/001—Oxiranes
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J1/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, not substituted in position 17 beta by a carbon atom, e.g. estrane, androstane
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J21/00—Normal steroids containing carbon, hydrogen, halogen or oxygen having an oxygen-containing hetero ring spiro-condensed with the cyclopenta(a)hydrophenanthrene skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J3/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by one carbon atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J53/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton has been modified by condensation with a carbocyclic rings or by formation of an additional ring by means of a direct link between two ring carbon atoms, including carboxyclic rings fused to the cyclopenta(a)hydrophenanthrene skeleton are included in this class
    • C07J53/002—Carbocyclic rings fused
    • C07J53/004—3 membered carbocyclic rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Steroid Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

1,186,794. 2α,3α-Epoxy-steroids. SHIONOGI & CO. Ltd. 22 April, 1968 [25 April, 1967], No. 18875/68. Heading C2U. Novel compounds of formula (wherein R 1 is C 1-3 alkyl; R 2 is C 1-4 alkyl; X is an oxo or ketal group, or a group where R<SP>1</SP> is H or C 1-4 hydrocarbyl and R<SP>11</SP> is H, C 1-11 optionally substituted hydrocarboncarboxylic acyl, C 1-7 alkyl, cycloalkyl or up to 7 carbon atoms and optionally substituted by a 1-(C 1-4 alkoxy) group, or is a tetrahydropyranyl or tetrahydrofuranyl group; and the wavy line denotes the α- or #-configuration) are prepared by reacting the corresponding 2 - alkyl - #<SP>2</SP> - compounds with an epoxidizing agent. The products may be interconverted by conventional transformations of the 17-substituents. Compounds of the above formula are said to exhibit antiestrogenic, uterotropic, implantation-inhibition, myogenic, androgenic, estrogenic, anti-cancer and anti-uterotropic activities and to enhance the estrogenic activity of estrogens, and may be made up with carriers, diluents or coatings into pharmaceutical compositions for oral or parenteral administration.
GB08875/68A 1967-04-25 1968-04-22 2beta,7-Lower-Alkyl-2alpha,3alpha-Epoxy-17-Oxygenated 5alpha-Androstane Derivatives Expired GB1186794A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP2646967 1967-04-25

Publications (1)

Publication Number Publication Date
GB1186794A true GB1186794A (en) 1970-04-02

Family

ID=12194364

Family Applications (1)

Application Number Title Priority Date Filing Date
GB08875/68A Expired GB1186794A (en) 1967-04-25 1968-04-22 2beta,7-Lower-Alkyl-2alpha,3alpha-Epoxy-17-Oxygenated 5alpha-Androstane Derivatives

Country Status (5)

Country Link
CH (1) CH560231A5 (en)
DE (1) DE1768293A1 (en)
FR (1) FR1560197A (en)
GB (1) GB1186794A (en)
NL (1) NL6805872A (en)

Also Published As

Publication number Publication date
CH560231A5 (en) 1975-03-27
NL6805872A (en) 1968-10-28
FR1560197A (en) 1969-03-14
DE1768293A1 (en) 1971-09-30

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Legal Events

Date Code Title Description
PS Patent sealed [section 19, patents act 1949]
PLNP Patent lapsed through nonpayment of renewal fees