GB1176999A - A New Antibiotic Bikaverin Effective against Leishmania Brasiliensis and a Method of Preparing Same - Google Patents
A New Antibiotic Bikaverin Effective against Leishmania Brasiliensis and a Method of Preparing SameInfo
- Publication number
- GB1176999A GB1176999A GB2523067A GB2523067A GB1176999A GB 1176999 A GB1176999 A GB 1176999A GB 2523067 A GB2523067 A GB 2523067A GB 2523067 A GB2523067 A GB 2523067A GB 1176999 A GB1176999 A GB 1176999A
- Authority
- GB
- United Kingdom
- Prior art keywords
- antibiotic
- chloroform
- bikaverin
- effective against
- hexane
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07G—COMPOUNDS OF UNKNOWN CONSTITUTION
- C07G11/00—Antibiotics
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Abstract
1,176,999. The antibiotic bikaverin. CESKOSLOVENSKA AKADEMIE VED. 1 June, 1967 [2 June, 1966], No. 25230/67. Heading C2A. An antibiotic bikaverin, effective against Leishmania brasiliensis, is an acid giving a red colour in acid media and a blue-purple in alkaline media, it is soluble in chloroform, slightly soluble in butanol, benzene, ethyl acetate and vegetable oils; insoluble in water, petroleum ether and hexane; it sublimes above 250‹ C.; m.pt. 315-320‹ C., elementary analysis 59À23% C and 3À07% H; molecular weight 382; empirical formula C 19 H 12 O 9 , ultraviolet absorption as in Fig. 2 (not shown), with maxima at 254 nm. and 278 nm., infra-red absorption as in Fig. 1. The antibiotic is extracted from the mycelium resulting from the production of gibberellins by cultivating Gibberella fujikuroi strain U or Fusarium oxysporum Schlecht strain No. 1-70. The extraction is by means of chloroform, trichloroethylene or a mixture thereof wih methanol or ethanol at pH 1 to 6À5. The broth has preferably been fermented 72 to 96 hours. Purification is obtained by treating the crude antibiotic with petroleum ether or n-hexane to remove impurities, dissolving in chloroform, treating the organic solution with aqueous KOH, filtering off the precipitate, dissolving in chloroform with the aid of hydrochloric acid, washing with water, removing solvent and recrystallizing from chloroform-methanol. A pharmaceutical composition for topical application comprises the antibiotic bikaverin and a carrier.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CS375966 | 1966-06-02 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB1176999A true GB1176999A (en) | 1970-01-07 |
Family
ID=5378594
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB2523067A Expired GB1176999A (en) | 1966-06-02 | 1967-06-01 | A New Antibiotic Bikaverin Effective against Leishmania Brasiliensis and a Method of Preparing Same |
Country Status (2)
| Country | Link |
|---|---|
| DE (1) | DE1617407A1 (en) |
| GB (1) | GB1176999A (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20150140029A1 (en) * | 2012-03-13 | 2015-05-21 | University of Macau, Av. Padre Tomas Pereira Taipa | Extracts from fusarium oxysporums and use thereof |
-
1967
- 1967-05-31 DE DE19671617407 patent/DE1617407A1/en active Pending
- 1967-06-01 GB GB2523067A patent/GB1176999A/en not_active Expired
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20150140029A1 (en) * | 2012-03-13 | 2015-05-21 | University of Macau, Av. Padre Tomas Pereira Taipa | Extracts from fusarium oxysporums and use thereof |
| US9950020B2 (en) * | 2012-03-13 | 2018-04-24 | University Of Macau | Extracts from fusarium oxysporum and use thereof |
Also Published As
| Publication number | Publication date |
|---|---|
| DE1617407A1 (en) | 1971-01-14 |
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