GB1172919A - A Method for Preparing Pancreatic Heparinoids - Google Patents

A Method for Preparing Pancreatic Heparinoids

Info

Publication number
GB1172919A
GB1172919A GB3307167A GB3307167A GB1172919A GB 1172919 A GB1172919 A GB 1172919A GB 3307167 A GB3307167 A GB 3307167A GB 3307167 A GB3307167 A GB 3307167A GB 1172919 A GB1172919 A GB 1172919A
Authority
GB
United Kingdom
Prior art keywords
heparinoids
pancreas
amount
pancreatic
proteolysis
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB3307167A
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
MICRON DI BIANCHINI DOTTOR PIE
Original Assignee
MICRON DI BIANCHINI DOTTOR PIE
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by MICRON DI BIANCHINI DOTTOR PIE filed Critical MICRON DI BIANCHINI DOTTOR PIE
Publication of GB1172919A publication Critical patent/GB1172919A/en
Expired legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08K—Use of inorganic or non-macromolecular organic substances as compounding ingredients
    • C08K13/00—Use of mixtures of ingredients not covered by one single of the preceding main groups, each of these compounds being essential
    • C08K13/02—Organic and inorganic ingredients

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Organic Chemistry (AREA)
  • Polymers & Plastics (AREA)
  • Molecular Biology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)

Abstract

1,172,919. Pancreatic heparinoids. MICRON DI BIANCHINI DOTTOR PIETRO & C.- S.N.C. 19 July, 1967 [22 July, 1966], No. 33071/67. Heading A5B. Pancreatic heparinoids are prepared by:- (a) subjecting mammal or fish pancreas to proteolysis by adding to the bulk or mass an aqueous alkaline solution of pH 7-8.5 comprising at least one antibiotic acting as bacterial floro inhibitor which is penicillin in an amount of 10,000-50,000 units of activity per kg of pancreas, or a tetracycline or chloramphenicol in an amount of 5-50 mg/kg of pancreas; (b) maintaining the suspension at 20-50‹C for 12- 48 hours out of contact with air; (c) heating at 70-100‹C for 10-45 minutes (d) separating the proteinous parts from the suspension; (e) subjecting the liquid obtained by separation; after adjusting it to a pH of 5-6.5 with an acid, to a treatment with a polar organic solvent in an amount of 2-5 vols/vol of liquid obtained and (f) allowing it to settle and collecting a hypophase having a high content of low molecular weight heparinoid. The alkaline solution of stage (a) may contain trypsin, chymotrypsin or papain. The proteolysis may be carried out in the presence of a reducing agent such as sodium hypophosphate or cysteine.
GB3307167A 1966-07-22 1967-07-19 A Method for Preparing Pancreatic Heparinoids Expired GB1172919A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
IT1695766 1966-07-22

Publications (1)

Publication Number Publication Date
GB1172919A true GB1172919A (en) 1969-12-03

Family

ID=11149585

Family Applications (1)

Application Number Title Priority Date Filing Date
GB3307167A Expired GB1172919A (en) 1966-07-22 1967-07-19 A Method for Preparing Pancreatic Heparinoids

Country Status (3)

Country Link
FR (1) FR1558919A (en)
GB (1) GB1172919A (en)
LU (1) LU53450A1 (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3936351A (en) * 1973-06-14 1976-02-03 Opocrin S.R.L. Method for preparing glucoronyl-glucosamino-glycan sulphates exhibiting antilipasaemic activity

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3936351A (en) * 1973-06-14 1976-02-03 Opocrin S.R.L. Method for preparing glucoronyl-glucosamino-glycan sulphates exhibiting antilipasaemic activity

Also Published As

Publication number Publication date
FR1558919A (en) 1969-03-07
LU53450A1 (en) 1967-06-19

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Legal Events

Date Code Title Description
PS Patent sealed
PLNP Patent lapsed through nonpayment of renewal fees