GB1159571A - Improvements in or relating to Nucleoside Derivatives and the manufacture thereof - Google Patents
Improvements in or relating to Nucleoside Derivatives and the manufacture thereofInfo
- Publication number
- GB1159571A GB1159571A GB27139/66A GB2713966A GB1159571A GB 1159571 A GB1159571 A GB 1159571A GB 27139/66 A GB27139/66 A GB 27139/66A GB 2713966 A GB2713966 A GB 2713966A GB 1159571 A GB1159571 A GB 1159571A
- Authority
- GB
- United Kingdom
- Prior art keywords
- treating
- agent
- phosphates
- give
- viii
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 238000004519 manufacturing process Methods 0.000 title 1
- 150000003833 nucleoside derivatives Chemical class 0.000 title 1
- 239000003795 chemical substances by application Substances 0.000 abstract 7
- 150000001875 compounds Chemical class 0.000 abstract 7
- QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Chemical compound CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 abstract 6
- 229910019142 PO4 Inorganic materials 0.000 abstract 3
- 239000003513 alkali Substances 0.000 abstract 3
- 239000002585 base Substances 0.000 abstract 3
- OPTASPLRGRRNAP-UHFFFAOYSA-N cytosine Natural products NC=1C=CNC(=O)N=1 OPTASPLRGRRNAP-UHFFFAOYSA-N 0.000 abstract 3
- 239000000203 mixture Substances 0.000 abstract 3
- NJDPBWLDVFCXNP-UHFFFAOYSA-L 2-cyanoethyl phosphate Chemical compound [O-]P([O-])(=O)OCCC#N NJDPBWLDVFCXNP-UHFFFAOYSA-L 0.000 abstract 2
- RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 abstract 2
- 206010028980 Neoplasm Diseases 0.000 abstract 2
- 241000700605 Viruses Species 0.000 abstract 2
- 238000004587 chromatography analysis Methods 0.000 abstract 2
- 229940104302 cytosine Drugs 0.000 abstract 2
- -1 hydrocarbon carboxylic acid Chemical class 0.000 abstract 2
- 239000000543 intermediate Substances 0.000 abstract 2
- 230000000865 phosphorylative effect Effects 0.000 abstract 2
- HTSGKJQDMSTCGS-UHFFFAOYSA-N 1,4-bis(4-chlorophenyl)-2-(4-methylphenyl)sulfonylbutane-1,4-dione Chemical compound C1=CC(C)=CC=C1S(=O)(=O)C(C(=O)C=1C=CC(Cl)=CC=1)CC(=O)C1=CC=C(Cl)C=C1 HTSGKJQDMSTCGS-UHFFFAOYSA-N 0.000 abstract 1
- NGNBDVOYPDDBFK-UHFFFAOYSA-N 2-[2,4-di(pentan-2-yl)phenoxy]acetyl chloride Chemical compound CCCC(C)C1=CC=C(OCC(Cl)=O)C(C(C)CCC)=C1 NGNBDVOYPDDBFK-UHFFFAOYSA-N 0.000 abstract 1
- CPELXLSAUQHCOX-UHFFFAOYSA-M Bromide Chemical compound [Br-] CPELXLSAUQHCOX-UHFFFAOYSA-M 0.000 abstract 1
- 239000004215 Carbon black (E152) Substances 0.000 abstract 1
- QOSSAOTZNIDXMA-UHFFFAOYSA-N Dicylcohexylcarbodiimide Chemical compound C1CCCCC1N=C=NC1CCCCC1 QOSSAOTZNIDXMA-UHFFFAOYSA-N 0.000 abstract 1
- CPELXLSAUQHCOX-UHFFFAOYSA-N Hydrogen bromide Chemical compound Br CPELXLSAUQHCOX-UHFFFAOYSA-N 0.000 abstract 1
- XQFRJNBWHJMXHO-RRKCRQDMSA-N IDUR Chemical compound C1[C@H](O)[C@@H](CO)O[C@H]1N1C(=O)NC(=O)C(I)=C1 XQFRJNBWHJMXHO-RRKCRQDMSA-N 0.000 abstract 1
- 108091034117 Oligonucleotide Proteins 0.000 abstract 1
- 241000187747 Streptomyces Species 0.000 abstract 1
- 241000700618 Vaccinia virus Species 0.000 abstract 1
- 125000002252 acyl group Chemical group 0.000 abstract 1
- 150000008064 anhydrides Chemical class 0.000 abstract 1
- 230000003115 biocidal effect Effects 0.000 abstract 1
- 150000001718 carbodiimides Chemical class 0.000 abstract 1
- 125000004432 carbon atom Chemical group C* 0.000 abstract 1
- 230000001472 cytotoxic effect Effects 0.000 abstract 1
- 125000005982 diphenylmethyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])(*)C1=C([H])C([H])=C([H])C([H])=C1[H] 0.000 abstract 1
- 229930195733 hydrocarbon Natural products 0.000 abstract 1
- 150000003840 hydrochlorides Chemical class 0.000 abstract 1
- 238000000338 in vitro Methods 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 244000005700 microbiome Species 0.000 abstract 1
- 239000002777 nucleoside Substances 0.000 abstract 1
- 125000003835 nucleoside group Chemical group 0.000 abstract 1
- 239000003960 organic solvent Substances 0.000 abstract 1
- 235000021317 phosphate Nutrition 0.000 abstract 1
- 150000003013 phosphoric acid derivatives Chemical class 0.000 abstract 1
- 230000026731 phosphorylation Effects 0.000 abstract 1
- 238000006366 phosphorylation reaction Methods 0.000 abstract 1
- 229920000642 polymer Polymers 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 125000002221 trityl group Chemical group [H]C1=C([H])C([H])=C([H])C([H])=C1C([*])(C1=C(C(=C(C(=C1[H])[H])[H])[H])[H])C1=C([H])C([H])=C([H])C([H])=C1[H] 0.000 abstract 1
- 210000004881 tumor cell Anatomy 0.000 abstract 1
- 238000005406 washing Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/06—Pyrimidine radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/06—Pyrimidine radicals
- C07H19/10—Pyrimidine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Biochemistry (AREA)
- Biotechnology (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Saccharide Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US468190A US3338882A (en) | 1965-06-28 | 1965-06-28 | 2'-and 3'-phosphates of 1-beta-d-arabinofuranosylcytosine |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB1159571A true GB1159571A (en) | 1969-07-30 |
Family
ID=23858778
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB27139/66A Expired GB1159571A (en) | 1965-06-28 | 1966-06-17 | Improvements in or relating to Nucleoside Derivatives and the manufacture thereof |
Country Status (6)
| Country | Link |
|---|---|
| US (1) | US3338882A (forum.php) |
| CH (1) | CH518950A (forum.php) |
| DE (1) | DE1620636A1 (forum.php) |
| GB (1) | GB1159571A (forum.php) |
| IL (1) | IL25768A (forum.php) |
| NL (1) | NL6608939A (forum.php) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3487068A (en) * | 1966-12-16 | 1969-12-30 | Upjohn Co | Lincomycin-2-phosphates,7-substituted compounds and salts thereof |
| US3894000A (en) * | 1971-01-27 | 1975-07-08 | Upjohn Co | Ara-cytidine derivatives and process of preparation |
| US3998807A (en) * | 1972-03-03 | 1976-12-21 | Syntex (U.S.A.) Inc. | Arabinofuranosyl cytosines and methods of making |
| US4404368A (en) * | 1981-02-17 | 1983-09-13 | Alvarado Urbina Gabriel G | Lyophilized phosphorylated nucleosides |
| US4711955A (en) * | 1981-04-17 | 1987-12-08 | Yale University | Modified nucleotides and methods of preparing and using same |
| US7947817B2 (en) * | 2003-06-30 | 2011-05-24 | Roche Molecular Systems, Inc. | Synthesis and compositions of 2'-terminator nucleotides |
| US7745125B2 (en) * | 2004-06-28 | 2010-06-29 | Roche Molecular Systems, Inc. | 2′-terminator related pyrophosphorolysis activated polymerization |
-
1965
- 1965-06-28 US US468190A patent/US3338882A/en not_active Expired - Lifetime
-
1966
- 1966-05-13 IL IL25768A patent/IL25768A/en unknown
- 1966-06-17 GB GB27139/66A patent/GB1159571A/en not_active Expired
- 1966-06-24 DE DE19661620636 patent/DE1620636A1/de active Pending
- 1966-06-28 NL NL6608939A patent/NL6608939A/xx unknown
- 1966-06-28 CH CH933766A patent/CH518950A/de not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| DE1620636A1 (de) | 1970-02-12 |
| US3338882A (en) | 1967-08-29 |
| CH518950A (de) | 1972-02-15 |
| NL6608939A (forum.php) | 1966-12-29 |
| IL25768A (en) | 1970-02-19 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PS | Patent sealed [section 19, patents act 1949] | ||
| PLNP | Patent lapsed through nonpayment of renewal fees |