GB1152626A - Rubella Vaccine - Google Patents

Rubella Vaccine

Info

Publication number
GB1152626A
GB1152626A GB31477/67A GB3147767A GB1152626A GB 1152626 A GB1152626 A GB 1152626A GB 31477/67 A GB31477/67 A GB 31477/67A GB 3147767 A GB3147767 A GB 3147767A GB 1152626 A GB1152626 A GB 1152626A
Authority
GB
United Kingdom
Prior art keywords
culture
virus
rubella
media
harvests
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB31477/67A
Inventor
Eugene Bernard Buynak
Maurice Ralph Hilleman
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merck and Co Inc
Original Assignee
Merck and Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck and Co Inc filed Critical Merck and Co Inc
Priority to GB31477/67A priority Critical patent/GB1152626A/en
Publication of GB1152626A publication Critical patent/GB1152626A/en
Expired legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/12—Viral antigens
    • A61K39/20—Rubella virus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/12—Viral antigens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
    • A61K2039/525—Virus
    • A61K2039/5254—Virus avirulent or attenuated
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2770/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses positive-sense
    • C12N2770/00011—Details
    • C12N2770/36011—Togaviridae
    • C12N2770/36211—Rubivirus, e.g. rubella virus
    • C12N2770/36234—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Virology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Immunology (AREA)
  • Medicinal Chemistry (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Chemical & Material Sciences (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)

Abstract

1,152,626. Measles vaccine. MERCK & CO. Inc. 7 July, 1967, No. 31477/67. Heading A5B. A rubella vaccine is prepared by isolating rubella virus from clinical material by inoculation of duck embryo or grivet monkey tissue culture and incubating at 30-38‹C.; successively passing the virus through culture media to attenuate the virus, at least ten of such passages being in media comprising minced and trypsinised 9-11 day old decapitated and amputated duck embryo culture in a cell growth medium at 30-38‹C., each passage being followed by infectivity titrations on sample harvests taken at 2-14 day intervals, the harvests being frozen until tested and re-inoculated in a culture medium if too virulent. The serial passages may include incubations in grivet monkey kidney cultures or in embryonated hens eggs.
GB31477/67A 1967-07-07 1967-07-07 Rubella Vaccine Expired GB1152626A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
GB31477/67A GB1152626A (en) 1967-07-07 1967-07-07 Rubella Vaccine

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB31477/67A GB1152626A (en) 1967-07-07 1967-07-07 Rubella Vaccine

Publications (1)

Publication Number Publication Date
GB1152626A true GB1152626A (en) 1969-05-21

Family

ID=10323681

Family Applications (1)

Application Number Title Priority Date Filing Date
GB31477/67A Expired GB1152626A (en) 1967-07-07 1967-07-07 Rubella Vaccine

Country Status (1)

Country Link
GB (1) GB1152626A (en)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2076787A5 (en) * 1970-01-28 1971-10-15 Merieux Inst Lyophilisation stabiliser - for viruses contg potassium phosphate lactose and albumin
DE2950004A1 (en) * 1978-12-22 1980-07-03 Immuno Ag METHOD FOR PRODUCING EARLY SUMMER MENINGOENZEPHALITIS VIRUS (TBE VIRUS) VACCINES

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2076787A5 (en) * 1970-01-28 1971-10-15 Merieux Inst Lyophilisation stabiliser - for viruses contg potassium phosphate lactose and albumin
DE2950004A1 (en) * 1978-12-22 1980-07-03 Immuno Ag METHOD FOR PRODUCING EARLY SUMMER MENINGOENZEPHALITIS VIRUS (TBE VIRUS) VACCINES

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Legal Events

Date Code Title Description
PS Patent sealed
PCNP Patent ceased through non-payment of renewal fee