GB1147698A - New tetracycline derivatives - Google Patents
New tetracycline derivativesInfo
- Publication number
- GB1147698A GB1147698A GB5627566A GB5627566A GB1147698A GB 1147698 A GB1147698 A GB 1147698A GB 5627566 A GB5627566 A GB 5627566A GB 5627566 A GB5627566 A GB 5627566A GB 1147698 A GB1147698 A GB 1147698A
- Authority
- GB
- United Kingdom
- Prior art keywords
- formula
- compounds
- tetracyclines
- dec
- bis
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/65—Tetracyclines
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C233/00—Carboxylic acid amides
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
1,147,698. Tetracyclines. LES LABORATORIES DAUSSE. 15 Dec., 1966 [15 Dec., 1965; 14 March, 1966], No. 56275/66. Heading C2A. [Also in Division A5] The invention comprises 2-carbonamidosubstituted tetracyclines of formula in which represents a tetracycline, chlorotetracycline, oxytetracycline or 6-dimethylchlorotetracycline residue; R 1 is H or C 1 to C 4 alkyl; R 2 is C r to C 4 alkyl; R 1 and R 2 may be the same or different, and A is C 2 to C 10 alkylene; and pharmaceutically acceptable acid addition salts. Typical compounds are N,N<SP>1</SP>-bis- (tetracyclino - methylene) - N,N<SP>1</SP> - dimethylethylene diamine and N,N<SP>1</SP> bis-(tetracyclinoethylidene)-N,N<SP>1</SP>- dimethylethylene diamine. Salts are formed with, e.g. hydrochloric, citric, gluconic and penicillin acids. The compounds are formed by condensing the appropriate tetracycline antibiotic with an N,N<SP>1</SP>-disubstituted alkylene diamine of formula in an inert diluent in the presence of an aldehyde of formula R 1 CHO, wherein R 1 has the above meaning. The compounds are very soluble in water and are non-toxic and effective antibacterials (see Division A5).
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR42306A FR1482843A (en) | 1965-12-15 | 1965-12-15 | New tetracycline derivatives and their preparation process |
| FR53289A FR5668M (en) | 1965-12-15 | 1966-03-14 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB1147698A true GB1147698A (en) | 1969-04-02 |
Family
ID=26167762
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB5627566A Expired GB1147698A (en) | 1965-12-15 | 1966-12-15 | New tetracycline derivatives |
Country Status (6)
| Country | Link |
|---|---|
| BE (1) | BE690632A (en) |
| DE (1) | DE1568970A1 (en) |
| FR (2) | FR1482843A (en) |
| GB (1) | GB1147698A (en) |
| LU (1) | LU52575A1 (en) |
| NL (2) | NL6617654A (en) |
-
0
- NL NL125840D patent/NL125840C/xx active
-
1965
- 1965-12-15 FR FR42306A patent/FR1482843A/en not_active Expired
-
1966
- 1966-03-14 FR FR53289A patent/FR5668M/fr not_active Expired
- 1966-12-02 BE BE690632D patent/BE690632A/xx unknown
- 1966-12-12 LU LU52575D patent/LU52575A1/xx unknown
- 1966-12-13 DE DE19661568970 patent/DE1568970A1/en active Pending
- 1966-12-15 NL NL6617654A patent/NL6617654A/xx unknown
- 1966-12-15 GB GB5627566A patent/GB1147698A/en not_active Expired
Also Published As
| Publication number | Publication date |
|---|---|
| DE1568970A1 (en) | 1970-04-02 |
| FR5668M (en) | 1968-01-02 |
| BE690632A (en) | 1967-06-02 |
| NL6617654A (en) | 1967-06-16 |
| FR1482843A (en) | 1967-06-02 |
| NL125840C (en) | |
| LU52575A1 (en) | 1967-06-12 |
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