GB1146868A - Novel 2-oxa-gonatrienes and processes for their preparation - Google Patents

Novel 2-oxa-gonatrienes and processes for their preparation

Info

Publication number
GB1146868A
GB1146868A GB5710366A GB5710366A GB1146868A GB 1146868 A GB1146868 A GB 1146868A GB 5710366 A GB5710366 A GB 5710366A GB 5710366 A GB5710366 A GB 5710366A GB 1146868 A GB1146868 A GB 1146868A
Authority
GB
United Kingdom
Prior art keywords
gona
oxa
triene
diene
hydroxymethyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB5710366A
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sanofi Aventis France
Original Assignee
Roussel Uclaf SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from FR54503A external-priority patent/FR5422M/fr
Priority claimed from FR79512A external-priority patent/FR5898M/fr
Application filed by Roussel Uclaf SA filed Critical Roussel Uclaf SA
Publication of GB1146868A publication Critical patent/GB1146868A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/08—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms
    • C07D295/096—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms separated by carbocyclic rings or by carbon chains interrupted by carbocyclic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/10—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by doubly bound oxygen or sulphur atoms
    • C07D295/112—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by doubly bound oxygen or sulphur atoms with the ring nitrogen atoms and the doubly bound oxygen or sulfur atoms separated by carbocyclic rings or by carbon chains interrupted by carbocyclic rings
    • C07D295/116—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by doubly bound oxygen or sulphur atoms with the ring nitrogen atoms and the doubly bound oxygen or sulfur atoms separated by carbocyclic rings or by carbon chains interrupted by carbocyclic rings with the doubly bound oxygen or sulfur atoms directly attached to a carbocyclic ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J73/00—Steroids in which the cyclopenta[a]hydrophenanthrene skeleton has been modified by substitution of one or two carbon atoms by hetero atoms
    • C07J73/001—Steroids in which the cyclopenta[a]hydrophenanthrene skeleton has been modified by substitution of one or two carbon atoms by hetero atoms by one hetero atom
    • C07J73/003—Steroids in which the cyclopenta[a]hydrophenanthrene skeleton has been modified by substitution of one or two carbon atoms by hetero atoms by one hetero atom by oxygen as hetero atom

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Steroid Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

1,146,868. 2-Oxa-gona-trienes. ROUSSELUCLAF. 21 Dec., 1966 [23 Dec., 1965; 22 March, 1966; 11 Oct., 1966], No. 57103/66. Heading C2C. Novel compounds having the formulµ wherein R represents an alkyl radical, and X represents a hydrogen atom, a saturated or unsaturated aliphatic hydrocarbon radical optionally containing an oxygen atom within the hydrocarbon chain, or an acyl group derived from an organic carboxylic acid, are obtained by reacting a 10-hydroxymethyl-des- A-gona-9,11-dien-5-one with an alkyl halogenoacetate in the presence of zinc to form a 5#-2- oxa-gona-9, 11 -diene-3-one or a corresponding 5 - hydroxy - 5 - alkoxycarbonylmethyl - 10 - hydroxymethyl - des - A - gona - 9,11 - diene or a mixture thereof, and reacting the latter compounds or a mixture thereof with a strong acid to obtain the desired 2-oxa-gona-4,9,11- triene-3-one. Pharmaceutical compositions having anabolising and androgenic activity and containing 2 - oxa - gona - 4,9,11 - triene - 3 - ones are administered orally, perlingually, transcutaneously or rectally.
GB5710366A 1965-12-23 1966-12-21 Novel 2-oxa-gonatrienes and processes for their preparation Expired GB1146868A (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
FR43566 1965-12-23
FR54503A FR5422M (en) 1965-12-23 1966-03-22
FR79512A FR5898M (en) 1966-10-11 1966-10-11

Publications (1)

Publication Number Publication Date
GB1146868A true GB1146868A (en) 1969-03-26

Family

ID=27242791

Family Applications (1)

Application Number Title Priority Date Filing Date
GB5710366A Expired GB1146868A (en) 1965-12-23 1966-12-21 Novel 2-oxa-gonatrienes and processes for their preparation

Country Status (8)

Country Link
BE (1) BE691404A (en)
CH (2) CH471778A (en)
DE (1) DE1543842C3 (en)
DK (1) DK117001B (en)
GB (1) GB1146868A (en)
IL (1) IL27131A (en)
NL (1) NL6618081A (en)
SE (1) SE318273B (en)

Also Published As

Publication number Publication date
DE1543842B2 (en) 1974-03-28
CH471778A (en) 1969-04-30
DE1543842C3 (en) 1974-11-07
CH511253A (en) 1971-08-15
SE318273B (en) 1969-12-08
DE1543842A1 (en) 1972-03-30
IL27131A (en) 1973-06-29
BE691404A (en) 1967-06-19
NL6618081A (en) 1967-06-26
DK117001B (en) 1970-03-09

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