GB1141960A - 17-imidazolyl androstane derivatives - Google Patents

17-imidazolyl androstane derivatives

Info

Publication number
GB1141960A
GB1141960A GB4668767A GB4668767A GB1141960A GB 1141960 A GB1141960 A GB 1141960A GB 4668767 A GB4668767 A GB 4668767A GB 4668767 A GB4668767 A GB 4668767A GB 1141960 A GB1141960 A GB 1141960A
Authority
GB
United Kingdom
Prior art keywords
imidazolyl
androstane derivatives
oct
formula
compounds
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB4668767A
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Pfizer Italia SRL
Original Assignee
Farmaceutici Italia SpA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Farmaceutici Italia SpA filed Critical Farmaceutici Italia SpA
Publication of GB1141960A publication Critical patent/GB1141960A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D233/88—Nitrogen atoms, e.g. allantoin
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J43/00—Normal steroids having a nitrogen-containing hetero ring spiro-condensed or not condensed with the cyclopenta(a)hydrophenanthrene skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J53/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton has been modified by condensation with a carbocyclic rings or by formation of an additional ring by means of a direct link between two ring carbon atoms, including carboxyclic rings fused to the cyclopenta(a)hydrophenanthrene skeleton are included in this class
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J71/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton is condensed with a heterocyclic ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J75/00—Processes for the preparation of steroids in general

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Steroid Compounds (AREA)

Abstract

1,141,960. 17-lmidazolyl-androstane derivatives. SOC. FARMACEUTICI ITALIA. 12 Oct., 1967 [12 Oct., 1966], No. 46687/67. Heading C2U. Novel compounds of formula (wherein X-Y is -CH 2 -H 2 - or -CH= CH-; R is H 2 , H(OH) or O; R 1 is H,F or Cl; R 2 is H, F or CH 3 ; R 3 is H or C 1-10 carboxylic acyl; W is H or OH; Z is H, OH or CH 3 ; or W and Z are together a 16α,17α-isopropylidenedioxy group) are prepared from the corresponding 20-oxo-21-hydroxy-pregnenes by reaction with guanidine or a salt thereof, followed, if required, by N-acylation. The compounds of Formula I are stated to possess anti-inflammatory, antirheumatic and antiallergic activity and may be administered orally, parenterally, or topically in the form of pharmaceutical compositions with a liquid or solid vehicle.
GB4668767A 1966-10-12 1967-10-12 17-imidazolyl androstane derivatives Expired GB1141960A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
IT2876666 1966-10-12

Publications (1)

Publication Number Publication Date
GB1141960A true GB1141960A (en) 1969-02-05

Family

ID=11224145

Family Applications (1)

Application Number Title Priority Date Filing Date
GB4668767A Expired GB1141960A (en) 1966-10-12 1967-10-12 17-imidazolyl androstane derivatives

Country Status (1)

Country Link
GB (1) GB1141960A (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2015071657A1 (en) * 2013-11-14 2015-05-21 The University Of Manchester Selective glucocorticoid receptor ligands

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2015071657A1 (en) * 2013-11-14 2015-05-21 The University Of Manchester Selective glucocorticoid receptor ligands

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