GB1140400A - Therapeutic compositions and a process for the manufacture thereof - Google Patents

Therapeutic compositions and a process for the manufacture thereof

Info

Publication number
GB1140400A
GB1140400A GB22370/67A GB2237067A GB1140400A GB 1140400 A GB1140400 A GB 1140400A GB 22370/67 A GB22370/67 A GB 22370/67A GB 2237067 A GB2237067 A GB 2237067A GB 1140400 A GB1140400 A GB 1140400A
Authority
GB
United Kingdom
Prior art keywords
adhesive composition
core
acetyl
phenol
amino
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB22370/67A
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
F Hoffmann La Roche AG
Hoffmann La Roche Inc
Original Assignee
F Hoffmann La Roche AG
Hoffmann La Roche Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by F Hoffmann La Roche AG, Hoffmann La Roche Inc filed Critical F Hoffmann La Roche AG
Publication of GB1140400A publication Critical patent/GB1140400A/en
Expired legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5073—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals having two or more different coatings optionally including drug-containing subcoatings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K33/00—Medicinal preparations containing inorganic active ingredients
    • A61K33/42—Phosphorus; Compounds thereof

Abstract

1,140,400. Capsules. F. HOFFMANN-LA ROCHE & CO., A.G. 15 May, 1967 [16 May, 1966], No. 22370/67. Headng A5B. A therapeutic composition for the treatment of coughs and colds comprises capsules containing (A) discrete beadlets comprising N - acetyl - p - amino - phenol (paracetamol) and dextromethorphan or a salt as the active ingredients, (B) discrete beadlets comprising N - acetyl - p - amino - phenol, a salt of chlorapheniramine and a salt of phenylephrine as the active ingredients, (C) N - acetyl - p - amino - phenol crystals and (D) inert filler materials; said beadlets (A) comprising (1) N - acetyl - p - amino - phenol as a core material (2) an adhesive composition overlaying said core material, (3) dextramethorphan or a salt thereof dispersed upon the adhesive treated core material and retained thereon by said adhesive composition, (4) an adhesive composition overlaying said medicamentcoated core and (5) tricalcium phosphate dispersed upon said adhesive-treated, medicament-coated core and retained thereon by said adhesive composition and said beadlets (B) comprising (6) N - acetyl - p - amino phenol as a core material, (7) an adhesive composition overlaying the core material, (8) tricalcium phosphate dispersed upon said adhesive-treated core and retained thereon by said adhesive composition, (9) an adhesive composition overlaying the tricalcium phosphate coated core, (10) a medicament mixture comprising (a) a salt of chlorpheniramine and (b) a salt of phenylephrine, dispersed upon the adhesivetreated tricalcium phosphate-coated core and retained thereon by said adhesive composition, (11) an adhesive composition overlaying the medicament mixture-coated-core and (12) tricalcium phosphate dispersed upon the adhesivetreated, medicament core and retained thereon by said adhesive composition. The adhesive composition (2), (4), (7), (9) and (11) may be a syrup comprising from 10% to 20% by weight of acacia, from 45% to 60% of sugar and from 30% to 35% of water. Salts may be. formed with hydrochloric, phosphoric, nitric, acetic, benzoic, citric, malic, maleic, tartaric and salicylic acids. N - acetyl - p - amino - phenol core material is preferably used in the form of crystals. The Example relates to a composition comprising dextromethorphan hydrobromide, chloropheniramine maleate, phenylephrine hydrochloride and paracetamol as active ingredients.
GB22370/67A 1966-05-16 1967-05-15 Therapeutic compositions and a process for the manufacture thereof Expired GB1140400A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US55017166A 1966-05-16 1966-05-16

Publications (1)

Publication Number Publication Date
GB1140400A true GB1140400A (en) 1969-01-15

Family

ID=24196036

Family Applications (1)

Application Number Title Priority Date Filing Date
GB22370/67A Expired GB1140400A (en) 1966-05-16 1967-05-15 Therapeutic compositions and a process for the manufacture thereof

Country Status (7)

Country Link
US (1) US3446891A (en)
BE (1) BE698429A (en)
DE (1) DE1617522A1 (en)
ES (1) ES340549A1 (en)
FR (1) FR7195M (en)
GB (1) GB1140400A (en)
NL (1) NL6706752A (en)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2419722A1 (en) * 1978-03-13 1979-10-12 Bayer Italia Spa Entero-soluble pharmaceutical granules - comprising an active core coated with sugar and two copolymer layers
US4631284A (en) * 1984-11-19 1986-12-23 Mallinckrodt, Inc. Acetaminophen compositions containing low doses of chlorpheniramine maleate, method for preparing same and tablets formed therefrom

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2058562B (en) * 1979-09-14 1983-11-30 Beecham Group Ltd Pharmaceutical compositions containing paracetamol and ascorbic acid
CA1194799A (en) * 1981-12-10 1985-10-08 Eric L. Nelson Method and composition for reducing menstrual pain
US4867984A (en) * 1984-11-06 1989-09-19 Nagin K. Patel Drug in bead form and process for preparing same
FR2584604B1 (en) * 1985-07-15 1988-11-04 Veyron Froment Laboratoire THERAPEUTIC COMPOSITION CONSTITUTING A NEW ORAL GALENIC FORM FOR IMPROVING THE KINETICS OF BIOAVAILABILITY
AU2062892A (en) * 1991-08-16 1993-02-18 Mcneil-Ppc, Inc. Potentiation of antitussive effect of dextromethorphan
AU670567B2 (en) * 1992-03-05 1996-07-25 American Home Products Corporation Pharmaceutical coated cores
US5348747A (en) * 1992-03-05 1994-09-20 American Home Products Corporation Pharmaceutical coating sugars

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2419722A1 (en) * 1978-03-13 1979-10-12 Bayer Italia Spa Entero-soluble pharmaceutical granules - comprising an active core coated with sugar and two copolymer layers
US4631284A (en) * 1984-11-19 1986-12-23 Mallinckrodt, Inc. Acetaminophen compositions containing low doses of chlorpheniramine maleate, method for preparing same and tablets formed therefrom

Also Published As

Publication number Publication date
US3446891A (en) 1969-05-27
FR7195M (en) 1969-08-18
NL6706752A (en) 1967-11-17
ES340549A1 (en) 1968-06-16
BE698429A (en) 1967-11-13
DE1617522A1 (en) 1971-04-08

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