GB1132854A - Novel anilides and pharmaceutical compositions containing them - Google Patents

Novel anilides and pharmaceutical compositions containing them

Info

Publication number
GB1132854A
GB1132854A GB1308865A GB1308865A GB1132854A GB 1132854 A GB1132854 A GB 1132854A GB 1308865 A GB1308865 A GB 1308865A GB 1308865 A GB1308865 A GB 1308865A GB 1132854 A GB1132854 A GB 1132854A
Authority
GB
United Kingdom
Prior art keywords
substituted
group
substituent
respect
hydrogen
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB1308865A
Inventor
Bernard Keat Martin
John Pomfret Verge
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Aspro Nicholas Ltd
Original Assignee
Aspro Nicholas Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Aspro Nicholas Ltd filed Critical Aspro Nicholas Ltd
Priority to GB1308865A priority Critical patent/GB1132854A/en
Priority to NL6603932A priority patent/NL6603932A/xx
Priority to BE678441D priority patent/BE678441A/xx
Priority to DE19661543302 priority patent/DE1543302A1/en
Priority to FR55124A priority patent/FR5475M/fr
Publication of GB1132854A publication Critical patent/GB1132854A/en
Expired legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A61K31/52—Purines, e.g. adenine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
    • A61K31/22—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin
    • A61K31/23—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin of acids having a carboxyl group bound to a chain of seven or more carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/60—Salicylic acid; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/60—Salicylic acid; Derivatives thereof
    • A61K31/618—Salicylic acid; Derivatives thereof having the carboxyl group in position 1 esterified, e.g. salsalate
    • A61K31/621—Salicylic acid; Derivatives thereof having the carboxyl group in position 1 esterified, e.g. salsalate having the hydroxy group in position 2 esterified, e.g. benorylate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K33/00—Medicinal preparations containing inorganic active ingredients
    • A61K33/42—Phosphorus; Compounds thereof

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Emergency Medicine (AREA)
  • Inorganic Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

1,132,854. Substituted anilides. ASPRONICHOLAS Ltd. 25 March, 1966 [27 March, 1965; 22 Sept., 1965], Nos. 13088/65 and 40329/65. Heading C2C. [Also in Division A5] Novel anilides of the general formula wherein R represents an aliphatic hydrocarbon group having from 3 to 6 carbon atoms, R 1 represents a hydrogen atom or an alkyl group and R 2 represents an aliphatic acyl or carbocyclic aroyl group having from 2 to 10 carbon atoms with the proviso that (a) when R 1 represents hydrogen and R 2 represents an acetyl group, then R is not an alkyl or isoamyl group in an ortho position with respect to the OR 1 substituent, (b) when R 1 is methyl or ethyl and R 2 is acetyl, then R is not an isopropyl, t-butyl or cyclohexyl group in an ortho position with respect to the OR 1 substituent, (c) when R 1 is hydrogen and R 2 is benzoyl, then R is not isopropyl in a meta position with respect to the OR 1 substituent, and (d) when R 1 is hydrogen and R 2 is n-hexoyl, then R is not n-hexyl in an ortho position with respect to the OR 1 substituent, are prepared by acylating the required substituted aniline and, in the case where a required p-aminophenol is used as the reactant, alkylating the resulting R-substituted 4-acylaminophenol or 4-aroylaminophenol to form a desired compound wherein R 1 is alkyl. R-substituted-4-aminophenols where R has the above significance, are prepared by coupling the alkali metal salt of the required R-substituted-phenol with a diazonium salt and reducing the resulting azo compound.
GB1308865A 1965-03-27 1965-03-27 Novel anilides and pharmaceutical compositions containing them Expired GB1132854A (en)

Priority Applications (5)

Application Number Priority Date Filing Date Title
GB1308865A GB1132854A (en) 1965-03-27 1965-03-27 Novel anilides and pharmaceutical compositions containing them
NL6603932A NL6603932A (en) 1965-03-27 1966-03-25
BE678441D BE678441A (en) 1965-03-27 1966-03-25
DE19661543302 DE1543302A1 (en) 1965-03-27 1966-03-26 Acetanilide derivatives and processes for their preparation
FR55124A FR5475M (en) 1965-03-27 1966-03-26

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB1308865A GB1132854A (en) 1965-03-27 1965-03-27 Novel anilides and pharmaceutical compositions containing them
GB4032965 1965-09-22

Publications (1)

Publication Number Publication Date
GB1132854A true GB1132854A (en) 1968-11-06

Family

ID=26249538

Family Applications (1)

Application Number Title Priority Date Filing Date
GB1308865A Expired GB1132854A (en) 1965-03-27 1965-03-27 Novel anilides and pharmaceutical compositions containing them

Country Status (5)

Country Link
BE (1) BE678441A (en)
DE (1) DE1543302A1 (en)
FR (1) FR5475M (en)
GB (1) GB1132854A (en)
NL (1) NL6603932A (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2003007875A2 (en) * 2001-07-16 2003-01-30 Hoegestaett Edward Compounds with analgesic, antipyretic and/or anti-inflammatory activity

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2003007875A2 (en) * 2001-07-16 2003-01-30 Hoegestaett Edward Compounds with analgesic, antipyretic and/or anti-inflammatory activity
WO2003007875A3 (en) * 2001-07-16 2003-04-17 Edward Hoegestaett Compounds with analgesic, antipyretic and/or anti-inflammatory activity

Also Published As

Publication number Publication date
FR5475M (en) 1967-10-23
NL6603932A (en) 1966-09-28
BE678441A (en) 1966-09-26
DE1543302A1 (en) 1969-08-07

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