GB1129358A - 5,8-dihydro-5-oxopyrido[2,3-d]pyrimidine derivatives, and processes for the preparation thereof - Google Patents
5,8-dihydro-5-oxopyrido[2,3-d]pyrimidine derivatives, and processes for the preparation thereofInfo
- Publication number
- GB1129358A GB1129358A GB40213/66A GB4021366A GB1129358A GB 1129358 A GB1129358 A GB 1129358A GB 40213/66 A GB40213/66 A GB 40213/66A GB 4021366 A GB4021366 A GB 4021366A GB 1129358 A GB1129358 A GB 1129358A
- Authority
- GB
- United Kingdom
- Prior art keywords
- alkyl
- radical
- compound
- general formula
- converting
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- BYTRPZLYYIPRLJ-UHFFFAOYSA-N 8h-pyrido[2,3-d]pyrimidin-5-one Chemical class C1=NC=C2C(O)=CC=NC2=N1 BYTRPZLYYIPRLJ-UHFFFAOYSA-N 0.000 title abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 10
- 125000000217 alkyl group Chemical group 0.000 abstract 6
- 125000003545 alkoxy group Chemical group 0.000 abstract 4
- 150000002148 esters Chemical class 0.000 abstract 4
- 239000002253 acid Substances 0.000 abstract 3
- BALXIBHGWJIQTM-UHFFFAOYSA-N 2-[(pyrimidin-4-ylamino)methylidene]propanedioic acid Chemical class OC(=O)C(C(O)=O)=CNC1=CC=NC=N1 BALXIBHGWJIQTM-UHFFFAOYSA-N 0.000 abstract 2
- 150000001412 amines Chemical class 0.000 abstract 2
- 238000006243 chemical reaction Methods 0.000 abstract 2
- 238000010438 heat treatment Methods 0.000 abstract 2
- 239000007868 Raney catalyst Substances 0.000 abstract 1
- NPXOKRUENSOPAO-UHFFFAOYSA-N Raney nickel Chemical compound [Al].[Ni] NPXOKRUENSOPAO-UHFFFAOYSA-N 0.000 abstract 1
- 229910000564 Raney nickel Inorganic materials 0.000 abstract 1
- 238000005903 acid hydrolysis reaction Methods 0.000 abstract 1
- 238000005904 alkaline hydrolysis reaction Methods 0.000 abstract 1
- 125000004414 alkyl thio group Chemical group 0.000 abstract 1
- 229940100198 alkylating agent Drugs 0.000 abstract 1
- 239000002168 alkylating agent Substances 0.000 abstract 1
- 230000000844 anti-bacterial effect Effects 0.000 abstract 1
- 239000003054 catalyst Substances 0.000 abstract 1
- 125000000753 cycloalkyl group Chemical group 0.000 abstract 1
- 125000005843 halogen group Chemical group 0.000 abstract 1
- 125000000623 heterocyclic group Chemical group 0.000 abstract 1
- 230000007062 hydrolysis Effects 0.000 abstract 1
- 238000006460 hydrolysis reaction Methods 0.000 abstract 1
- 125000002768 hydroxyalkyl group Chemical group 0.000 abstract 1
- 238000002347 injection Methods 0.000 abstract 1
- 239000007924 injection Substances 0.000 abstract 1
- 125000004433 nitrogen atom Chemical group N* 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 150000008518 pyridopyrimidines Chemical class 0.000 abstract 1
- 238000006798 ring closing metathesis reaction Methods 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 239000007858 starting material Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP5499865 | 1965-09-08 | ||
| JP5499765 | 1965-09-08 | ||
| JP5560865 | 1965-09-10 | ||
| JP5560765 | 1965-09-10 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB1129358A true GB1129358A (en) | 1968-10-02 |
Family
ID=27463140
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB40213/66A Expired GB1129358A (en) | 1965-09-08 | 1966-09-08 | 5,8-dihydro-5-oxopyrido[2,3-d]pyrimidine derivatives, and processes for the preparation thereof |
Country Status (2)
| Country | Link |
|---|---|
| FR (1) | FR7582M (enrdf_load_stackoverflow) |
| GB (1) | GB1129358A (enrdf_load_stackoverflow) |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2196159A1 (enrdf_load_stackoverflow) * | 1972-08-14 | 1974-03-15 | Dainippon Pharmaceutical Co | |
| US3992380A (en) * | 1975-03-03 | 1976-11-16 | Sterling Drug Inc. | 5,8-Dihydro-5-oxo-2-(4-or 3-pyridinyl)pyrido[2,3-d]pyrimidine-6-carboxylic acids and esters |
| US4017622A (en) | 1972-12-18 | 1977-04-12 | Dainippon Pharmaceutical Co., Ltd. | Piperazine derivatives |
-
1966
- 1966-09-08 GB GB40213/66A patent/GB1129358A/en not_active Expired
- 1966-09-08 FR FR75707A patent/FR7582M/fr not_active Expired
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2196159A1 (enrdf_load_stackoverflow) * | 1972-08-14 | 1974-03-15 | Dainippon Pharmaceutical Co | |
| US4017622A (en) | 1972-12-18 | 1977-04-12 | Dainippon Pharmaceutical Co., Ltd. | Piperazine derivatives |
| US3992380A (en) * | 1975-03-03 | 1976-11-16 | Sterling Drug Inc. | 5,8-Dihydro-5-oxo-2-(4-or 3-pyridinyl)pyrido[2,3-d]pyrimidine-6-carboxylic acids and esters |
Also Published As
| Publication number | Publication date |
|---|---|
| FR7582M (enrdf_load_stackoverflow) | 1970-01-12 |
| DE1670533A1 (de) | 1970-11-12 |
| DE1670533B2 (de) | 1975-07-03 |
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