GB1120755A - Process for preparing a tetrapeptide - Google Patents

Process for preparing a tetrapeptide

Info

Publication number
GB1120755A
GB1120755A GB26276/66A GB2627666A GB1120755A GB 1120755 A GB1120755 A GB 1120755A GB 26276/66 A GB26276/66 A GB 26276/66A GB 2627666 A GB2627666 A GB 2627666A GB 1120755 A GB1120755 A GB 1120755A
Authority
GB
United Kingdom
Prior art keywords
tetrapeptide
group
phenh2
asp
try
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB26276/66A
Inventor
John Selwyn Morley
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Imperial Chemical Industries Ltd
Original Assignee
Imperial Chemical Industries Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Imperial Chemical Industries Ltd filed Critical Imperial Chemical Industries Ltd
Priority to GB26276/66A priority Critical patent/GB1120755A/en
Publication of GB1120755A publication Critical patent/GB1120755A/en
Expired legal-status Critical Current

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K5/00Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/10Tetrapeptides
    • C07K5/1024Tetrapeptides with the first amino acid being heterocyclic
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02PCLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00Technologies relating to chemical industry
    • Y02P20/50Improvements relating to the production of bulk chemicals
    • Y02P20/55Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Peptides Or Proteins (AREA)

Abstract

The tetrapeptide H-Try-Met-Asp(OH)-PheNH2 is prepared by replacing by H the protecting group X, and, if necessary, the group R, in the protected tetrapeptide X-Try-Met-Asp(OR)-PheNH2 (where X is benzyloxy-carbonyl optionally substituted in the benzene ring by one or more NO2 groups or halogen atoms, and R is H, alkyl or aralkyl) by interaction of the above protected derivative with H2 and a hydrogen atom catalyst in the presence of an organic base, followed, if necessary, by replacement by H of the group R by hydrolysis under acid (e.g. HCl or CF3COOH) or basic (e.g. NaOH) conditions.
GB26276/66A 1966-06-13 1966-06-13 Process for preparing a tetrapeptide Expired GB1120755A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
GB26276/66A GB1120755A (en) 1966-06-13 1966-06-13 Process for preparing a tetrapeptide

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB26276/66A GB1120755A (en) 1966-06-13 1966-06-13 Process for preparing a tetrapeptide

Publications (1)

Publication Number Publication Date
GB1120755A true GB1120755A (en) 1968-07-24

Family

ID=10241096

Family Applications (1)

Application Number Title Priority Date Filing Date
GB26276/66A Expired GB1120755A (en) 1966-06-13 1966-06-13 Process for preparing a tetrapeptide

Country Status (1)

Country Link
GB (1) GB1120755A (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4164571A (en) * 1976-09-21 1979-08-14 Commissariat A L'energie Atomique Medicament which antagonizes the action of gastrin and related polypeptides

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4164571A (en) * 1976-09-21 1979-08-14 Commissariat A L'energie Atomique Medicament which antagonizes the action of gastrin and related polypeptides

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