GB1117226A - Improvements in or relating to aralkenylamines having pharmacological activity - Google Patents
Improvements in or relating to aralkenylamines having pharmacological activityInfo
- Publication number
- GB1117226A GB1117226A GB29214/65A GB2921465A GB1117226A GB 1117226 A GB1117226 A GB 1117226A GB 29214/65 A GB29214/65 A GB 29214/65A GB 2921465 A GB2921465 A GB 2921465A GB 1117226 A GB1117226 A GB 1117226A
- Authority
- GB
- United Kingdom
- Prior art keywords
- prepared
- formula
- alkoxy
- alkyl
- chohcn
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 230000000144 pharmacologic effect Effects 0.000 title 1
- WFDIJRYMOXRFFG-UHFFFAOYSA-N Acetic anhydride Chemical compound CC(=O)OC(C)=O WFDIJRYMOXRFFG-UHFFFAOYSA-N 0.000 abstract 3
- 125000000217 alkyl group Chemical group 0.000 abstract 3
- 150000001875 compounds Chemical class 0.000 abstract 3
- ZETHHMPKDUSZQQ-UHFFFAOYSA-N Betulafolienepentol Natural products C1C=C(C)CCC(C(C)CCC=C(C)C)C2C(OC)OC(OC)C2=C1 ZETHHMPKDUSZQQ-UHFFFAOYSA-N 0.000 abstract 2
- NBBJYMSMWIIQGU-UHFFFAOYSA-N Propionic aldehyde Chemical compound CCC=O NBBJYMSMWIIQGU-UHFFFAOYSA-N 0.000 abstract 2
- PCSMJKASWLYICJ-UHFFFAOYSA-N Succinic aldehyde Chemical compound O=CCCC=O PCSMJKASWLYICJ-UHFFFAOYSA-N 0.000 abstract 2
- 125000003545 alkoxy group Chemical group 0.000 abstract 2
- 238000006243 chemical reaction Methods 0.000 abstract 2
- HEOKFDGOFROELJ-UHFFFAOYSA-N diacetal Natural products COc1ccc(C=C/c2cc(O)cc(OC3OC(COC(=O)c4cc(O)c(O)c(O)c4)C(O)C(O)C3O)c2)cc1O HEOKFDGOFROELJ-UHFFFAOYSA-N 0.000 abstract 2
- 150000003839 salts Chemical class 0.000 abstract 2
- KJPRLNWUNMBNBZ-QPJJXVBHSA-N (E)-cinnamaldehyde Chemical compound O=C\C=C\C1=CC=CC=C1 KJPRLNWUNMBNBZ-QPJJXVBHSA-N 0.000 abstract 1
- 101100241859 Mus musculus Oacyl gene Proteins 0.000 abstract 1
- 239000000219 Sympatholytic Substances 0.000 abstract 1
- AXMVYSVVTMKQSL-UHFFFAOYSA-N UNPD142122 Natural products OC1=CC=C(C=CC=O)C=C1O AXMVYSVVTMKQSL-UHFFFAOYSA-N 0.000 abstract 1
- 239000002253 acid Substances 0.000 abstract 1
- 125000004414 alkyl thio group Chemical group 0.000 abstract 1
- 230000029936 alkylation Effects 0.000 abstract 1
- 238000005804 alkylation reaction Methods 0.000 abstract 1
- 150000001412 amines Chemical class 0.000 abstract 1
- 230000000202 analgesic effect Effects 0.000 abstract 1
- 239000007864 aqueous solution Substances 0.000 abstract 1
- 150000003935 benzaldehydes Chemical class 0.000 abstract 1
- HUMNYLRZRPPJDN-UHFFFAOYSA-N benzenecarboxaldehyde Natural products O=CC1=CC=CC=C1 HUMNYLRZRPPJDN-UHFFFAOYSA-N 0.000 abstract 1
- 230000015572 biosynthetic process Effects 0.000 abstract 1
- ZTQSAGDEMFDKMZ-UHFFFAOYSA-N butyric aldehyde Natural products CCCC=O ZTQSAGDEMFDKMZ-UHFFFAOYSA-N 0.000 abstract 1
- 229940117916 cinnamic aldehyde Drugs 0.000 abstract 1
- KJPRLNWUNMBNBZ-UHFFFAOYSA-N cinnamic aldehyde Natural products O=CC=CC1=CC=CC=C1 KJPRLNWUNMBNBZ-UHFFFAOYSA-N 0.000 abstract 1
- 125000002871 cinnamic aldehydes group Chemical group 0.000 abstract 1
- 125000000753 cycloalkyl group Chemical group 0.000 abstract 1
- 239000003085 diluting agent Substances 0.000 abstract 1
- 125000005670 ethenylalkyl group Chemical group 0.000 abstract 1
- RTZKZFJDLAIYFH-UHFFFAOYSA-N ether Substances CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 abstract 1
- 229910052736 halogen Inorganic materials 0.000 abstract 1
- 150000002367 halogens Chemical class 0.000 abstract 1
- 230000007062 hydrolysis Effects 0.000 abstract 1
- 238000006460 hydrolysis reaction Methods 0.000 abstract 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 1
- QNGNSVIICDLXHT-UHFFFAOYSA-N para-ethylbenzaldehyde Natural products CCC1=CC=C(C=O)C=C1 QNGNSVIICDLXHT-UHFFFAOYSA-N 0.000 abstract 1
- 238000007911 parenteral administration Methods 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 125000005359 phenoxyalkyl group Chemical group 0.000 abstract 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 1
- 125000003884 phenylalkyl group Chemical group 0.000 abstract 1
- HRZFUMHJMZEROT-UHFFFAOYSA-L sodium disulfite Chemical compound [Na+].[Na+].[O-]S(=O)S([O-])(=O)=O HRZFUMHJMZEROT-UHFFFAOYSA-L 0.000 abstract 1
- 235000010262 sodium metabisulphite Nutrition 0.000 abstract 1
- 239000004296 sodium metabisulphite Substances 0.000 abstract 1
- 230000000948 sympatholitic effect Effects 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/13—Amines
- A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C33/00—Unsaturated compounds having hydroxy or O-metal groups bound to acyclic carbon atoms
- C07C33/28—Alcohols containing only six-membered aromatic rings as cyclic part with unsaturation outside the aromatic rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Steroid Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| NL6407943A NL6407943A (enrdf_load_stackoverflow) | 1964-07-11 | 1964-07-11 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB1117226A true GB1117226A (en) | 1968-06-19 |
Family
ID=19790501
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB29214/65A Expired GB1117226A (en) | 1964-07-11 | 1965-07-09 | Improvements in or relating to aralkenylamines having pharmacological activity |
Country Status (9)
| Country | Link |
|---|---|
| US (2) | US3420853A (enrdf_load_stackoverflow) |
| AT (2) | AT262259B (enrdf_load_stackoverflow) |
| BE (1) | BE666781A (enrdf_load_stackoverflow) |
| CH (1) | CH470345A (enrdf_load_stackoverflow) |
| DE (1) | DE1238898B (enrdf_load_stackoverflow) |
| ES (1) | ES315132A1 (enrdf_load_stackoverflow) |
| FR (2) | FR1476551A (enrdf_load_stackoverflow) |
| GB (1) | GB1117226A (enrdf_load_stackoverflow) |
| NL (1) | NL6407943A (enrdf_load_stackoverflow) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE10048714A1 (de) * | 2000-09-30 | 2002-04-11 | Gruenenthal Gmbh | 5-Amino-1-penlen-3-ol-Derivate |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4335124A (en) * | 1973-08-20 | 1982-06-15 | Sandoz, Inc. | 1-Alkyl, 1-phenyl-butenes |
| GB1479297A (en) * | 1974-07-04 | 1977-07-13 | Beecham Group Ltd | 4-substituted butan-2-ones but-3-en-2-ones butan-2-ols and but-3-en-2-ols and pharmaceutical compositions containing them |
| US4080474A (en) * | 1975-02-19 | 1978-03-21 | Beecham Group Limited | Hypolipidaemic compositions |
| DE2732750A1 (de) * | 1977-07-20 | 1979-02-08 | Merck Patent Gmbh | Basische thioaether und verfahren zu ihrer herstellung |
| FR2473518A1 (fr) * | 1980-01-16 | 1981-07-17 | Unicler | Derives du phenyl-1 morpholino-4 butene-1 ol-3, leur preparation et leur application en therapeutique |
| DE3015359A1 (de) * | 1980-04-22 | 1981-10-29 | Basf Ag, 6700 Ludwigshafen | Verfahren zur herstellung von 1-(4-hydroxy-phenyl)-butan-3-on sowie neue zwischenprodukte dieses verfahrens |
| CN114395379B (zh) * | 2022-01-24 | 2023-07-14 | 西南石油大学 | 一种插层改性纳米碳化钛复合水凝胶封堵剂及水基钻井液 |
-
1964
- 1964-07-11 NL NL6407943A patent/NL6407943A/xx unknown
-
1965
- 1965-07-07 DE DEN26997A patent/DE1238898B/de active Granted
- 1965-07-08 CH CH956965A patent/CH470345A/de not_active IP Right Cessation
- 1965-07-08 AT AT620665A patent/AT262259B/de active
- 1965-07-08 AT AT1035666A patent/AT258272B/de active
- 1965-07-09 GB GB29214/65A patent/GB1117226A/en not_active Expired
- 1965-07-09 ES ES0315132A patent/ES315132A1/es not_active Expired
- 1965-07-10 FR FR24258A patent/FR1476551A/fr not_active Expired
- 1965-07-12 US US471434A patent/US3420853A/en not_active Expired - Lifetime
- 1965-07-12 BE BE666781A patent/BE666781A/xx unknown
- 1965-10-09 FR FR34380A patent/FR5740M/fr not_active Expired
-
1968
- 1968-10-18 US US768925A patent/US3557148A/en not_active Expired - Lifetime
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE10048714A1 (de) * | 2000-09-30 | 2002-04-11 | Gruenenthal Gmbh | 5-Amino-1-penlen-3-ol-Derivate |
| US6815443B2 (en) | 2000-09-30 | 2004-11-09 | Gruenenthal Gmbh | 5-Amino-1-pentene-3-ol substituted derivatives |
Also Published As
| Publication number | Publication date |
|---|---|
| NL6407943A (enrdf_load_stackoverflow) | 1966-01-12 |
| FR5740M (enrdf_load_stackoverflow) | 1968-01-29 |
| CH470345A (de) | 1969-03-31 |
| DE1238898C2 (enrdf_load_stackoverflow) | 1967-11-23 |
| FR1476551A (fr) | 1967-04-14 |
| AT258272B (de) | 1967-11-10 |
| AT262259B (de) | 1968-06-10 |
| US3420853A (en) | 1969-01-07 |
| BE666781A (enrdf_load_stackoverflow) | 1966-01-12 |
| US3557148A (en) | 1971-01-19 |
| DE1238898B (de) | 1967-04-20 |
| ES315132A1 (es) | 1966-03-16 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| GB1164585A (en) | (3-benzoylphenyl) alkanoic acids | |
| GB1117226A (en) | Improvements in or relating to aralkenylamines having pharmacological activity | |
| GB1305502A (enrdf_load_stackoverflow) | ||
| GB1301224A (enrdf_load_stackoverflow) | ||
| GB1040735A (en) | 4-aryl-3-hydroxybutyric acid and esters, amides and salts thereof | |
| GB1320712A (en) | Antimicrobially active 5-nitroimidazole derivatives | |
| GB1379781A (en) | Furylmethyl morphinane derivatives and pharmaceutical compositions containing them | |
| GB1062714A (en) | -ß-(4'-acyloxy-4'-piperidyl)-ketones | |
| GB1173227A (en) | Amino-Isoquinolines | |
| IE36247L (en) | Hydroxy-cinnamic acid derivatives | |
| GB1239553A (enrdf_load_stackoverflow) | ||
| SE8003351L (sv) | Forfarande for framstellning av heterocykliska foreningar med terapeutisk verkan | |
| GB1245549A (en) | (thienylideneamino)oxy-alkanoic acid and derivatives thereof | |
| GB1377720A (en) | Hydroxy pyrimidines | |
| GB1208195A (en) | Process for producing benzodiazepine derivatives | |
| GB1174880A (en) | Derivatives of alpha-Piperazinophenylacetonitrile and process for manufacture of same | |
| GB1425347A (en) | N-thienylmethylbenzomorphanes and n-thienylmethylmorphinanes | |
| GB1354216A (en) | Substituted isoquinolines and a process for the preparation thereof | |
| GB1397434A (en) | Evomonoside derivatives | |
| GB1243186A (en) | Improvements in or relating to mandelamidine derivatives | |
| GB1131126A (en) | 2-vinyl-1,4-dihydroquinazoline derivatives | |
| GB1449222A (en) | N-hereroarylmethyl-desoxy-normorphines and-norcodeines | |
| Haggett et al. | The Preparation of β-(3, 4, 5-Trimethoxybenzoyl)-propionic Acid | |
| GB979555A (en) | New benzyl piperidyl ketones | |
| GB1214502A (en) | Indole derivatives |