GB1110360A - Piperazine derivatives and preparation thereof - Google Patents
Piperazine derivatives and preparation thereofInfo
- Publication number
- GB1110360A GB1110360A GB5586/67A GB558667A GB1110360A GB 1110360 A GB1110360 A GB 1110360A GB 5586/67 A GB5586/67 A GB 5586/67A GB 558667 A GB558667 A GB 558667A GB 1110360 A GB1110360 A GB 1110360A
- Authority
- GB
- United Kingdom
- Prior art keywords
- amidoxime
- fluorophenyl
- chlorobutyryl
- thienyl
- phenyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 150000004885 piperazines Chemical class 0.000 title abstract 2
- 229940066771 systemic antihistamines piperazine derivative Drugs 0.000 title abstract 2
- -1 1-substituted piperazine Chemical class 0.000 abstract 6
- 230000003993 interaction Effects 0.000 abstract 3
- 125000001255 4-fluorophenyl group Chemical group [H]C1=C([H])C(*)=C([H])C([H])=C1F 0.000 abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 2
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 2
- BBVIDBNAYOIXOE-UHFFFAOYSA-N 1,2,4-oxadiazole Chemical compound C=1N=CON=1 BBVIDBNAYOIXOE-UHFFFAOYSA-N 0.000 abstract 1
- 125000004198 2-fluorophenyl group Chemical group [H]C1=C([H])C(F)=C(*)C([H])=C1[H] 0.000 abstract 1
- 125000005809 3,4,5-trimethoxyphenyl group Chemical group [H]C1=C(OC([H])([H])[H])C(OC([H])([H])[H])=C(OC([H])([H])[H])C([H])=C1* 0.000 abstract 1
- 125000003349 3-pyridyl group Chemical group N1=C([H])C([*])=C([H])C([H])=C1[H] 0.000 abstract 1
- 125000000339 4-pyridyl group Chemical group N1=C([H])C([H])=C([*])C([H])=C1[H] 0.000 abstract 1
- 239000002253 acid Substances 0.000 abstract 1
- HFBMWMNUJJDEQZ-UHFFFAOYSA-N acryloyl chloride Chemical compound ClC(=O)C=C HFBMWMNUJJDEQZ-UHFFFAOYSA-N 0.000 abstract 1
- 239000004480 active ingredient Substances 0.000 abstract 1
- 125000000217 alkyl group Chemical group 0.000 abstract 1
- 230000001760 anti-analgesic effect Effects 0.000 abstract 1
- 230000003110 anti-inflammatory effect Effects 0.000 abstract 1
- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 abstract 1
- 125000002541 furyl group Chemical group 0.000 abstract 1
- 125000003854 p-chlorophenyl group Chemical group [H]C1=C([H])C(*)=C([H])C([H])=C1Cl 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 239000002243 precursor Substances 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 239000007858 starting material Substances 0.000 abstract 1
- 125000001544 thienyl group Chemical group 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| MC608A MC598A1 (fr) | 1966-02-16 | 1966-02-16 | Nouveaux composés chimiques et procédé pour leur préparation |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB1110360A true GB1110360A (en) | 1968-04-18 |
Family
ID=19737671
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB5586/67A Expired GB1110360A (en) | 1966-02-16 | 1967-02-06 | Piperazine derivatives and preparation thereof |
Country Status (7)
| Country | Link |
|---|---|
| CH (1) | CH478141A (https=) |
| DE (1) | DE1695392A1 (https=) |
| ES (1) | ES336777A1 (https=) |
| FR (1) | FR6671M (https=) |
| GB (1) | GB1110360A (https=) |
| MC (1) | MC598A1 (https=) |
| NL (1) | NL6702283A (https=) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4353904A (en) * | 1980-02-13 | 1982-10-12 | Basf Aktiengesellschaft | Phenylpiperazine derivatives of 1,3,4-oxadiazolylphenols, and therapeutic agents containing these compounds |
| JP2006522813A (ja) * | 2003-04-09 | 2006-10-05 | エクセリクシス， インク． | Ｔｉｅ−２モジュレータと使用方法 |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB0510139D0 (en) | 2005-05-18 | 2005-06-22 | Addex Pharmaceuticals Sa | Novel compounds B1 |
| DE102005061427A1 (de) * | 2005-12-22 | 2007-06-28 | Grünenthal GmbH | Substituierte Oxadiazol-Derivate |
-
1966
- 1966-02-16 MC MC608A patent/MC598A1/fr unknown
-
1967
- 1967-01-27 FR FR92738A patent/FR6671M/fr not_active Expired
- 1967-02-06 GB GB5586/67A patent/GB1110360A/en not_active Expired
- 1967-02-07 CH CH182267A patent/CH478141A/fr not_active IP Right Cessation
- 1967-02-10 DE DE19671695392 patent/DE1695392A1/de active Pending
- 1967-02-13 ES ES336777A patent/ES336777A1/es not_active Expired
- 1967-02-15 NL NL6702283A patent/NL6702283A/xx unknown
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4353904A (en) * | 1980-02-13 | 1982-10-12 | Basf Aktiengesellschaft | Phenylpiperazine derivatives of 1,3,4-oxadiazolylphenols, and therapeutic agents containing these compounds |
| JP2006522813A (ja) * | 2003-04-09 | 2006-10-05 | エクセリクシス， インク． | Ｔｉｅ−２モジュレータと使用方法 |
| JP4881725B2 (ja) * | 2003-04-09 | 2012-02-22 | エクセリクシス， インク． | Ｔｉｅ−２モジュレータと使用方法 |
| US8178570B2 (en) | 2003-04-09 | 2012-05-15 | Exelixis, Inc. | Tie-2 modulators and methods of use |
Also Published As
| Publication number | Publication date |
|---|---|
| CH478141A (fr) | 1969-09-15 |
| DE1695392A1 (de) | 1971-04-08 |
| ES336777A1 (es) | 1968-06-01 |
| MC598A1 (fr) | 1967-03-21 |
| NL6702283A (https=) | 1967-08-17 |
| FR6671M (https=) | 1969-02-03 |
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