GB1102428A - Cycloaliphatic amines and process for their manufacture - Google Patents
Cycloaliphatic amines and process for their manufactureInfo
- Publication number
- GB1102428A GB1102428A GB43974/65A GB4397465A GB1102428A GB 1102428 A GB1102428 A GB 1102428A GB 43974/65 A GB43974/65 A GB 43974/65A GB 4397465 A GB4397465 A GB 4397465A GB 1102428 A GB1102428 A GB 1102428A
- Authority
- GB
- United Kingdom
- Prior art keywords
- pyridyl
- diphenyl
- cyclohexanone
- hydroxy
- enone
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 150000001412 amines Chemical class 0.000 title 1
- 238000004519 manufacturing process Methods 0.000 title 1
- 238000000034 method Methods 0.000 title 1
- -1 heterocyclic radicals Chemical class 0.000 abstract 8
- 125000000217 alkyl group Chemical group 0.000 abstract 7
- 125000003118 aryl group Chemical group 0.000 abstract 7
- 235000010290 biphenyl Nutrition 0.000 abstract 7
- 239000004305 biphenyl Substances 0.000 abstract 7
- ZUOUZKKEUPVFJK-UHFFFAOYSA-N phenylbenzene Natural products C1=CC=CC=C1C1=CC=CC=C1 ZUOUZKKEUPVFJK-UHFFFAOYSA-N 0.000 abstract 7
- 150000001875 compounds Chemical class 0.000 abstract 5
- 150000003839 salts Chemical class 0.000 abstract 5
- 125000004105 2-pyridyl group Chemical group N1=C([*])C([H])=C([H])C([H])=C1[H] 0.000 abstract 4
- QGZKDVFQNNGYKY-UHFFFAOYSA-N Ammonia Chemical compound N QGZKDVFQNNGYKY-UHFFFAOYSA-N 0.000 abstract 4
- 125000004432 carbon atom Chemical group C* 0.000 abstract 4
- 150000003254 radicals Chemical class 0.000 abstract 4
- 239000007858 starting material Substances 0.000 abstract 4
- 125000001424 substituent group Chemical group 0.000 abstract 4
- 125000004172 4-methoxyphenyl group Chemical group [H]C1=C([H])C(OC([H])([H])[H])=C([H])C([H])=C1* 0.000 abstract 3
- 150000005840 aryl radicals Chemical class 0.000 abstract 3
- 125000004430 oxygen atom Chemical group O* 0.000 abstract 3
- 238000002360 preparation method Methods 0.000 abstract 3
- 239000000047 product Substances 0.000 abstract 3
- 150000001204 N-oxides Chemical class 0.000 abstract 2
- 125000002947 alkylene group Chemical group 0.000 abstract 2
- 229910021529 ammonia Inorganic materials 0.000 abstract 2
- 125000005843 halogen group Chemical group 0.000 abstract 2
- 125000003854 p-chlorophenyl group Chemical group [H]C1=C([H])C(*)=C([H])C([H])=C1Cl 0.000 abstract 2
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 abstract 2
- 125000000467 secondary amino group Chemical class [H]N([*:1])[*:2] 0.000 abstract 2
- GUHRQBVFOAYERB-UHFFFAOYSA-N (4-pyrrolidin-1-ylcyclohexyl) benzoate Chemical compound C=1C=CC=CC=1C(=O)OC(CC1)CCC1N1CCCC1 GUHRQBVFOAYERB-UHFFFAOYSA-N 0.000 abstract 1
- UUKRKWJGNHNTRG-NSCUHMNNSA-N (e)-4-(4-chlorophenyl)but-3-en-2-one Chemical compound CC(=O)\C=C\C1=CC=C(Cl)C=C1 UUKRKWJGNHNTRG-NSCUHMNNSA-N 0.000 abstract 1
- WRRZKDVBPZBNJN-ONEGZZNKSA-N (e)-4-(4-methoxyphenyl)but-3-en-2-one Chemical compound COC1=CC=C(\C=C\C(C)=O)C=C1 WRRZKDVBPZBNJN-ONEGZZNKSA-N 0.000 abstract 1
- KBJDTAPBOJLYMR-UHFFFAOYSA-N 1,3-diphenyl-2-pyridin-2-ylhexane-1,5-dione Chemical compound C1(=CC=CC=C1)C(C(C(CC(C)=O)C1=CC=CC=C1)C1=NC=CC=C1)=O KBJDTAPBOJLYMR-UHFFFAOYSA-N 0.000 abstract 1
- MIHMEDBBAZVCAR-UHFFFAOYSA-N 1-phenyl-2-quinolin-2-ylethanone Chemical compound C=1C=C2C=CC=CC2=NC=1CC(=O)C1=CC=CC=C1 MIHMEDBBAZVCAR-UHFFFAOYSA-N 0.000 abstract 1
- 125000005809 3,4,5-trimethoxyphenyl group Chemical group [H]C1=C(OC([H])([H])[H])C(OC([H])([H])[H])=C(OC([H])([H])[H])C([H])=C1* 0.000 abstract 1
- AIORPMKOLKCISC-UHFFFAOYSA-N 3,4,5-triphenylcyclohexan-1-ol Chemical compound C1(=CC=CC=C1)C1CC(CC(C1C1=CC=CC=C1)C1=CC=CC=C1)O AIORPMKOLKCISC-UHFFFAOYSA-N 0.000 abstract 1
- RCNJJMULISELBA-UHFFFAOYSA-N 3,4-diphenyl-5-pyridin-4-ylcyclohex-2-en-1-one Chemical compound C1(=CC=CC=C1)C1=CC(CC(C1C1=CC=CC=C1)C1=CC=NC=C1)=O RCNJJMULISELBA-UHFFFAOYSA-N 0.000 abstract 1
- JOYLVBYXNQLLPO-UHFFFAOYSA-N 3,5-bis(furan-2-yl)-4-pyridin-2-ylcyclohex-2-en-1-one Chemical compound O1C(=CC=C1)C1=CC(CC(C1C1=NC=CC=C1)C=1OC=CC1)=O JOYLVBYXNQLLPO-UHFFFAOYSA-N 0.000 abstract 1
- PJMNEIKKTORVNO-UHFFFAOYSA-N 3,5-bis(furan-2-yl)-4-pyridin-2-ylcyclohexan-1-one Chemical compound O1C(=CC=C1)C1CC(CC(C1C1=NC=CC=C1)C=1OC=CC1)=O PJMNEIKKTORVNO-UHFFFAOYSA-N 0.000 abstract 1
- QQIUAUDFIZRQCG-UHFFFAOYSA-N 3,5-diphenyl-4-pyridin-2-ylcyclohex-2-en-1-one Chemical compound C1(=CC=CC=C1)C1=CC(CC(C1C1=NC=CC=C1)C1=CC=CC=C1)=O QQIUAUDFIZRQCG-UHFFFAOYSA-N 0.000 abstract 1
- MKINXVSJXNDZMT-UHFFFAOYSA-N 3,5-diphenyl-4-pyridin-2-ylcyclohexan-1-one Chemical compound C1(=CC=CC=C1)C1CC(CC(C1C1=NC=CC=C1)C1=CC=CC=C1)=O MKINXVSJXNDZMT-UHFFFAOYSA-N 0.000 abstract 1
- GPDJRRUELXCWGY-UHFFFAOYSA-N 3,5-diphenyl-4-pyridin-4-ylcyclohex-2-en-1-one Chemical compound C1(=CC=CC=C1)C1=CC(CC(C1C1=CC=NC=C1)C1=CC=CC=C1)=O GPDJRRUELXCWGY-UHFFFAOYSA-N 0.000 abstract 1
- AGBKDTLCNHPMGN-UHFFFAOYSA-N 3,5-diphenyl-4-pyridin-4-ylcyclohexan-1-ol Chemical compound C1(=CC=CC=C1)C1CC(CC(C1C1=CC=NC=C1)C1=CC=CC=C1)O AGBKDTLCNHPMGN-UHFFFAOYSA-N 0.000 abstract 1
- IBKCEJDXZZNPKS-UHFFFAOYSA-N 3,5-diphenyl-4-pyridin-4-ylcyclohexan-1-one Chemical compound C1(=CC=CC=C1)C1CC(CC(C1C1=CC=NC=C1)C1=CC=CC=C1)=O IBKCEJDXZZNPKS-UHFFFAOYSA-N 0.000 abstract 1
- BJKVSCQZWNGHOX-UHFFFAOYSA-N 3,5-diphenyl-4-pyrimidin-4-ylcyclohex-2-en-1-one Chemical compound C1(=CC=CC=C1)C1=CC(CC(C1C1=NC=NC=C1)C1=CC=CC=C1)=O BJKVSCQZWNGHOX-UHFFFAOYSA-N 0.000 abstract 1
- ODRJHYYXQYLMEL-UHFFFAOYSA-N 3,5-diphenyl-4-pyrimidin-4-ylcyclohexan-1-one Chemical compound C1(=CC=CC=C1)C1CC(CC(C1C1=NC=NC=C1)C1=CC=CC=C1)=O ODRJHYYXQYLMEL-UHFFFAOYSA-N 0.000 abstract 1
- NITMSQPUJIYJGX-UHFFFAOYSA-N 3,5-diphenyl-4-quinolin-2-ylcyclohex-2-en-1-one Chemical compound C1(=CC=CC=C1)C1=CC(CC(C1C1=NC2=CC=CC=C2C=C1)C1=CC=CC=C1)=O NITMSQPUJIYJGX-UHFFFAOYSA-N 0.000 abstract 1
- YGYFKPHWSDIEHZ-UHFFFAOYSA-N 3,5-diphenyl-4-quinolin-2-ylcyclohexan-1-one Chemical compound C1(=CC=CC=C1)C1CC(CC(C1C1=NC2=CC=CC=C2C=C1)C1=CC=CC=C1)=O YGYFKPHWSDIEHZ-UHFFFAOYSA-N 0.000 abstract 1
- RVKHWCGBFGJBJF-UHFFFAOYSA-N 3-hydroxy-3,5-diphenyl-4-pyridin-2-ylcyclohexan-1-one Chemical compound C1(=CC=CC=C1)C1(CC(CC(C1C1=NC=CC=C1)C1=CC=CC=C1)=O)O RVKHWCGBFGJBJF-UHFFFAOYSA-N 0.000 abstract 1
- SYCSNFSEKILSJJ-UHFFFAOYSA-N 3-hydroxy-3,5-diphenyl-4-pyrimidin-4-ylcyclohexan-1-one Chemical compound C1(=CC=CC=C1)C1(CC(CC(C1C1=NC=NC=C1)C1=CC=CC=C1)=O)O SYCSNFSEKILSJJ-UHFFFAOYSA-N 0.000 abstract 1
- FFULCWPGBXGWQN-UHFFFAOYSA-N 3-hydroxy-3,5-diphenyl-4-quinolin-2-ylcyclohexan-1-one Chemical compound C1(=CC=CC=C1)C1(CC(CC(C1C1=NC2=CC=CC=C2C=C1)C1=CC=CC=C1)=O)O FFULCWPGBXGWQN-UHFFFAOYSA-N 0.000 abstract 1
- DPZIOGVAJXVGGL-UHFFFAOYSA-N 4-(3,4,5-trimethoxyphenyl)but-3-en-2-one Chemical compound COC1=CC(C=CC(C)=O)=CC(OC)=C1OC DPZIOGVAJXVGGL-UHFFFAOYSA-N 0.000 abstract 1
- AHPJOXSVJPJNPD-UHFFFAOYSA-N 4-hydroxy-4-pyridin-2-ylcyclohexan-1-one Chemical compound C=1C=CC=NC=1C1(O)CCC(=O)CC1 AHPJOXSVJPJNPD-UHFFFAOYSA-N 0.000 abstract 1
- OOEXNPORPQRXBJ-UHFFFAOYSA-N 4-oxo-2,6-diphenyl-1-pyridin-2-ylcyclohexane-1-carbonitrile Chemical compound C(#N)C1(C(CC(CC1C1=CC=CC=C1)=O)C1=CC=CC=C1)C1=NC=CC=C1 OOEXNPORPQRXBJ-UHFFFAOYSA-N 0.000 abstract 1
- DZHBOWRAWDWBPK-UHFFFAOYSA-N 4-pyridin-2-ylcyclohex-3-en-1-one Chemical compound C1C(=O)CCC(C=2N=CC=CC=2)=C1 DZHBOWRAWDWBPK-UHFFFAOYSA-N 0.000 abstract 1
- BHIIMPOVZNJDSZ-UHFFFAOYSA-N 4-pyridin-2-ylcyclohexan-1-one Chemical compound C1CC(=O)CCC1C1=CC=CC=N1 BHIIMPOVZNJDSZ-UHFFFAOYSA-N 0.000 abstract 1
- FVSJBIVLSOXEDU-UHFFFAOYSA-N 4-pyrrolidin-1-ylcyclohexan-1-ol Chemical compound C1CC(O)CCC1N1CCCC1 FVSJBIVLSOXEDU-UHFFFAOYSA-N 0.000 abstract 1
- RDGIABKZGSKWCC-UHFFFAOYSA-N 4-pyrrolidin-1-ylcyclohexan-1-one Chemical compound C1CC(=O)CCC1N1CCCC1 RDGIABKZGSKWCC-UHFFFAOYSA-N 0.000 abstract 1
- AVXURJPOCDRRFD-UHFFFAOYSA-N Hydroxylamine Chemical compound ON AVXURJPOCDRRFD-UHFFFAOYSA-N 0.000 abstract 1
- 208000001953 Hypotension Diseases 0.000 abstract 1
- 125000002252 acyl group Chemical group 0.000 abstract 1
- 125000003545 alkoxy group Chemical group 0.000 abstract 1
- 125000003277 amino group Chemical group 0.000 abstract 1
- 239000003674 animal food additive Substances 0.000 abstract 1
- 230000015572 biosynthetic process Effects 0.000 abstract 1
- 239000006227 byproduct Substances 0.000 abstract 1
- 239000002775 capsule Substances 0.000 abstract 1
- 229910052799 carbon Inorganic materials 0.000 abstract 1
- 239000003638 chemical reducing agent Substances 0.000 abstract 1
- JHIVVAPYMSGYDF-UHFFFAOYSA-N cyclohexyloxide Natural products O=C1CCCCC1 JHIVVAPYMSGYDF-UHFFFAOYSA-N 0.000 abstract 1
- 235000014113 dietary fatty acids Nutrition 0.000 abstract 1
- 239000002934 diuretic Substances 0.000 abstract 1
- 229940030606 diuretics Drugs 0.000 abstract 1
- 239000008298 dragée Substances 0.000 abstract 1
- 239000000839 emulsion Substances 0.000 abstract 1
- 150000002148 esters Chemical class 0.000 abstract 1
- 229930195729 fatty acid Natural products 0.000 abstract 1
- 239000000194 fatty acid Substances 0.000 abstract 1
- 150000004665 fatty acids Chemical class 0.000 abstract 1
- 125000003187 heptyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 abstract 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 1
- 208000021822 hypotensive Diseases 0.000 abstract 1
- 230000001077 hypotensive effect Effects 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 125000002950 monocyclic group Chemical group 0.000 abstract 1
- SYSQUGFVNFXIIT-UHFFFAOYSA-N n-[4-(1,3-benzoxazol-2-yl)phenyl]-4-nitrobenzenesulfonamide Chemical class C1=CC([N+](=O)[O-])=CC=C1S(=O)(=O)NC1=CC=C(C=2OC3=CC=CC=C3N=2)C=C1 SYSQUGFVNFXIIT-UHFFFAOYSA-N 0.000 abstract 1
- 125000004433 nitrogen atom Chemical group N* 0.000 abstract 1
- 229910052760 oxygen Inorganic materials 0.000 abstract 1
- 238000007911 parenteral administration Methods 0.000 abstract 1
- 125000001453 quaternary ammonium group Chemical group 0.000 abstract 1
- 239000000243 solution Substances 0.000 abstract 1
- BDHFUVZGWQCTTF-UHFFFAOYSA-N sulfonic acid Chemical compound OS(=O)=O BDHFUVZGWQCTTF-UHFFFAOYSA-N 0.000 abstract 1
- 125000004434 sulfur atom Chemical group 0.000 abstract 1
- 239000000829 suppository Substances 0.000 abstract 1
- 239000000725 suspension Substances 0.000 abstract 1
- 239000003826 tablet Substances 0.000 abstract 1
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 abstract 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D213/28—Radicals substituted by singly-bound oxygen or sulphur atoms
- C07D213/30—Oxygen atoms
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D213/36—Radicals substituted by singly-bound nitrogen atoms
- C07D213/38—Radicals substituted by singly-bound nitrogen atoms having only hydrogen or hydrocarbon radicals attached to the substituent nitrogen atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D213/44—Radicals substituted by doubly-bound oxygen, sulfur, or nitrogen atoms, or by two such atoms singly-bound to the same carbon atom
- C07D213/46—Oxygen atoms
- C07D213/50—Ketonic radicals
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D213/54—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D213/55—Acids; Esters
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D213/54—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D213/57—Nitriles
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/12—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D215/14—Radicals substituted by oxygen atoms
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/26—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/02—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms containing only hydrogen and carbon atoms in addition to the ring hetero elements
- C07D295/027—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms containing only hydrogen and carbon atoms in addition to the ring hetero elements containing only one hetero ring
- C07D295/033—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms containing only hydrogen and carbon atoms in addition to the ring hetero elements containing only one hetero ring with the ring nitrogen atoms directly attached to carbocyclic rings
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
- C07D295/08—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms
- C07D295/096—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms separated by carbocyclic rings or by carbon chains interrupted by carbocyclic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
- C07D295/10—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by doubly bound oxygen or sulphur atoms
- C07D295/112—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by doubly bound oxygen or sulphur atoms with the ring nitrogen atoms and the doubly bound oxygen or sulfur atoms separated by carbocyclic rings or by carbon chains interrupted by carbocyclic rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pyridine Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US40657664A | 1964-10-26 | 1964-10-26 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB1102428A true GB1102428A (en) | 1968-02-07 |
Family
ID=23608586
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB43974/65A Expired GB1102428A (en) | 1964-10-26 | 1965-10-18 | Cycloaliphatic amines and process for their manufacture |
Country Status (7)
| Country | Link |
|---|---|
| US (1) | US3455944A (enExample) |
| AT (1) | AT263009B (enExample) |
| BE (1) | BE671369A (enExample) |
| ES (1) | ES318891A1 (enExample) |
| FR (3) | FR1473003A (enExample) |
| GB (1) | GB1102428A (enExample) |
| NL (1) | NL6513784A (enExample) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2006094248A1 (en) * | 2005-03-03 | 2006-09-08 | Sirtris Pharmaceuticals, Inc. | Aryl-substituted cyclic sirtuin modulators |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3652559A (en) * | 1968-05-13 | 1972-03-28 | Upjohn Co | Diaminocycloalkanes |
| DE3546751C2 (de) * | 1984-07-26 | 1997-02-13 | Mitsui Toatsu Chemicals | 4-(4-Pyridyl)cyclohexanon sowie Herstellung und Verwendung desselben |
| ATE140213T1 (de) * | 1990-03-08 | 1996-07-15 | Fujisawa Pharmaceutical Co | N-monosubstituierte cyclopentenylamine, ein verfahren zu ihrer herstellung, und ihre verwendung als medikament |
-
1965
- 1965-10-18 GB GB43974/65A patent/GB1102428A/en not_active Expired
- 1965-10-21 FR FR35785A patent/FR1473003A/fr not_active Expired
- 1965-10-25 ES ES0318891A patent/ES318891A1/es not_active Expired
- 1965-10-25 BE BE671369A patent/BE671369A/xx unknown
- 1965-10-25 AT AT963965A patent/AT263009B/de active
- 1965-10-25 NL NL6513784A patent/NL6513784A/xx unknown
-
1966
- 1966-01-20 FR FR46586A patent/FR5024M/fr not_active Expired
- 1966-01-20 FR FR46585A patent/FR6405M/fr not_active Expired
- 1966-05-11 US US549180A patent/US3455944A/en not_active Expired - Lifetime
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2006094248A1 (en) * | 2005-03-03 | 2006-09-08 | Sirtris Pharmaceuticals, Inc. | Aryl-substituted cyclic sirtuin modulators |
Also Published As
| Publication number | Publication date |
|---|---|
| US3455944A (en) | 1969-07-15 |
| BE671369A (enExample) | 1966-04-25 |
| NL6513784A (enExample) | 1966-04-27 |
| ES318891A1 (es) | 1967-04-01 |
| AT263009B (de) | 1968-07-10 |
| FR6405M (enExample) | 1968-10-28 |
| FR5024M (enExample) | 1967-04-24 |
| FR1473003A (fr) | 1967-03-17 |
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