GB1102259A - Process for preparing new derivative of mitomycin c and product obtained therefrom - Google Patents
Process for preparing new derivative of mitomycin c and product obtained therefromInfo
- Publication number
- GB1102259A GB1102259A GB35638/65A GB3563865A GB1102259A GB 1102259 A GB1102259 A GB 1102259A GB 35638/65 A GB35638/65 A GB 35638/65A GB 3563865 A GB3563865 A GB 3563865A GB 1102259 A GB1102259 A GB 1102259A
- Authority
- GB
- United Kingdom
- Prior art keywords
- mitomycin
- amino acids
- phthalyl
- formula
- acid
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains three hetero rings
- C07D487/14—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Abstract
1a - N - phthalyl a -amino acid derivatives of mitomycin C of Formula II <FORM:1102259/C2/1> wherein R is H, CH3, <FORM:1102259/C2/2> C6H5CH2 or CH3-S-CH2 -CH2, are prepared by reacting N-phthalylamino acid halides of Formula III <FORM:1102259/C2/3> wherein R is the same as in Formula II and X is halogen, with mitomycin C in the presence of a base and an inert solvent. The derivatives of the following amino acids are disclosed: L-alanine, L-phenylalanine, L-leucine, glycine, L-valine, L-isoleucine and L-methionine, e.g. 1a-N-phthalyl alanyl mitomycin C. The compounds are effective anti-tumour agents. N-Phthalyl a -amino acids are prepared by reacting a -amino acids with phthalic anhydride in the presence of an inert solvent and a base. The a -amino acids are those specified above. The acid may subsequently be treated with a halogenating agent, e.g. PCl5, SOCl2 to obtain the corresponding acid halide.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US68627067A | 1967-11-28 | 1967-11-28 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB1102259A true GB1102259A (en) | 1968-02-07 |
Family
ID=24755637
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB35638/65A Expired GB1102259A (en) | 1967-11-28 | 1965-08-19 | Process for preparing new derivative of mitomycin c and product obtained therefrom |
Country Status (3)
| Country | Link |
|---|---|
| US (1) | US3493583A (en) |
| DE (1) | DE1570041A1 (en) |
| GB (1) | GB1102259A (en) |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3226393A (en) * | 1962-06-07 | 1965-12-28 | American Cyanamid Co | N-substituted derivatives of mitomycin a and mitomycin c |
-
1965
- 1965-08-19 GB GB35638/65A patent/GB1102259A/en not_active Expired
- 1965-08-27 DE DE19651570041 patent/DE1570041A1/en active Pending
-
1967
- 1967-11-28 US US686270A patent/US3493583A/en not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| DE1570041A1 (en) | 1970-04-09 |
| US3493583A (en) | 1970-02-03 |
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