GB1098878A - d-4-phenyl-ª‡-methylphenylacetic acid and its derivatives and anti-inflammatory compositions containing such compounds and their racemic forms - Google Patents
d-4-phenyl-ª‡-methylphenylacetic acid and its derivatives and anti-inflammatory compositions containing such compounds and their racemic formsInfo
- Publication number
- GB1098878A GB1098878A GB1387665A GB1387665A GB1098878A GB 1098878 A GB1098878 A GB 1098878A GB 1387665 A GB1387665 A GB 1387665A GB 1387665 A GB1387665 A GB 1387665A GB 1098878 A GB1098878 A GB 1098878A
- Authority
- GB
- United Kingdom
- Prior art keywords
- phenyl
- esters
- acid
- ethyl
- anhydride
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 239000002253 acid Substances 0.000 title abstract 4
- 239000000203 mixture Substances 0.000 title abstract 2
- 230000003110 anti-inflammatory effect Effects 0.000 title 1
- 150000001875 compounds Chemical class 0.000 title 1
- 150000002148 esters Chemical class 0.000 abstract 4
- 150000008064 anhydrides Chemical class 0.000 abstract 3
- 239000007788 liquid Substances 0.000 abstract 3
- 150000003839 salts Chemical class 0.000 abstract 3
- 239000003085 diluting agent Substances 0.000 abstract 2
- ZUOUZKKEUPVFJK-UHFFFAOYSA-N diphenyl Chemical compound C1=CC=CC=C1C1=CC=CC=C1 ZUOUZKKEUPVFJK-UHFFFAOYSA-N 0.000 abstract 2
- 239000007787 solid Substances 0.000 abstract 2
- NGNBDVOYPDDBFK-UHFFFAOYSA-N 2-[2,4-di(pentan-2-yl)phenoxy]acetyl chloride Chemical compound CCCC(C)C1=CC=C(OCC(Cl)=O)C(C(C)CCC)=C1 NGNBDVOYPDDBFK-UHFFFAOYSA-N 0.000 abstract 1
- GUGQQGROXHPINL-UHFFFAOYSA-N 2-oxobutanoyl chloride Chemical compound CCC(=O)C(Cl)=O GUGQQGROXHPINL-UHFFFAOYSA-N 0.000 abstract 1
- ZCYVEMRRCGMTRW-UHFFFAOYSA-N 7553-56-2 Chemical compound [I] ZCYVEMRRCGMTRW-UHFFFAOYSA-N 0.000 abstract 1
- 206010061218 Inflammation Diseases 0.000 abstract 1
- CRZQGDNQQAALAY-UHFFFAOYSA-N Me ester-Phenylacetic acid Natural products COC(=O)CC1=CC=CC=C1 CRZQGDNQQAALAY-UHFFFAOYSA-N 0.000 abstract 1
- OAICVXFJPJFONN-UHFFFAOYSA-N Phosphorus Chemical compound [P] OAICVXFJPJFONN-UHFFFAOYSA-N 0.000 abstract 1
- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 abstract 1
- 235000010290 biphenyl Nutrition 0.000 abstract 1
- 239000004305 biphenyl Substances 0.000 abstract 1
- 238000009835 boiling Methods 0.000 abstract 1
- 239000003937 drug carrier Substances 0.000 abstract 1
- 125000005448 ethoxyethyl group Chemical group [H]C([H])([H])C([H])([H])OC([H])([H])C([H])([H])* 0.000 abstract 1
- JSNHSBCQHIQENB-UHFFFAOYSA-N ethyl 2-oxo-2-(4-phenylphenyl)acetate Chemical compound C1=CC(C(=O)C(=O)OCC)=CC=C1C1=CC=CC=C1 JSNHSBCQHIQENB-UHFFFAOYSA-N 0.000 abstract 1
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 abstract 1
- 230000003301 hydrolyzing effect Effects 0.000 abstract 1
- 230000004054 inflammatory process Effects 0.000 abstract 1
- 239000011630 iodine Substances 0.000 abstract 1
- 229910052740 iodine Inorganic materials 0.000 abstract 1
- VXWPONVCMVLXBW-UHFFFAOYSA-M magnesium;carbanide;iodide Chemical compound [CH3-].[Mg+2].[I-] VXWPONVCMVLXBW-UHFFFAOYSA-M 0.000 abstract 1
- 239000008016 pharmaceutical coating Substances 0.000 abstract 1
- 239000008024 pharmaceutical diluent Substances 0.000 abstract 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 1
- 238000002360 preparation method Methods 0.000 abstract 1
- 239000003380 propellant Substances 0.000 abstract 1
- 125000001436 propyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])[H] 0.000 abstract 1
- 238000010561 standard procedure Methods 0.000 abstract 1
- 239000000375 suspending agent Substances 0.000 abstract 1
- -1 tetrahydrofurfuryl Chemical group 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
- C07C69/612—Esters of carboxylic acids having a carboxyl group bound to an acyclic carbon atom and having a six-membered aromatic ring in the acid moiety
- C07C69/616—Esters of carboxylic acids having a carboxyl group bound to an acyclic carbon atom and having a six-membered aromatic ring in the acid moiety polycyclic
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C233/00—Carboxylic acid amides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C57/00—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms
- C07C57/30—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms containing six-membered aromatic rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US36579064A | 1964-05-07 | 1964-05-07 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB1098878A true GB1098878A (en) | 1968-01-10 |
Family
ID=23440368
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB2527367A Expired GB1098879A (en) | 1964-05-07 | 1965-04-01 | 4-phenyl-ª‡-methylphenyl acetic acid amides |
| GB1387665A Expired GB1098878A (en) | 1964-05-07 | 1965-04-01 | d-4-phenyl-ª‡-methylphenylacetic acid and its derivatives and anti-inflammatory compositions containing such compounds and their racemic forms |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB2527367A Expired GB1098879A (en) | 1964-05-07 | 1965-04-01 | 4-phenyl-ª‡-methylphenyl acetic acid amides |
Country Status (3)
| Country | Link |
|---|---|
| BE (1) | BE664187A (OSRAM) |
| GB (2) | GB1098879A (OSRAM) |
| IL (1) | IL23268A (OSRAM) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DK154418B (da) * | 1977-03-08 | 1988-11-14 | Boots Co Plc | Fremgangsmaade til oegning af maengdeandelen af en oensket enantiomer af en 2-arylpropionsyre |
| WO2006021441A1 (en) * | 2004-08-25 | 2006-03-02 | Cellzome Ag | Biphenyl-carboxylic acids and derivatives thereof and their use in therapy |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB1121722A (en) * | 1966-03-31 | 1968-07-31 | Ici Ltd | New carboxylic acid derivatives |
-
1965
- 1965-03-31 IL IL2326865A patent/IL23268A/en unknown
- 1965-04-01 GB GB2527367A patent/GB1098879A/en not_active Expired
- 1965-04-01 GB GB1387665A patent/GB1098878A/en not_active Expired
- 1965-05-19 BE BE664187D patent/BE664187A/xx unknown
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DK154418B (da) * | 1977-03-08 | 1988-11-14 | Boots Co Plc | Fremgangsmaade til oegning af maengdeandelen af en oensket enantiomer af en 2-arylpropionsyre |
| WO2006021441A1 (en) * | 2004-08-25 | 2006-03-02 | Cellzome Ag | Biphenyl-carboxylic acids and derivatives thereof and their use in therapy |
Also Published As
| Publication number | Publication date |
|---|---|
| GB1098879A (en) | 1968-01-10 |
| BE664187A (OSRAM) | 1965-11-19 |
| IL23268A (en) | 1969-02-27 |
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