GB1080790A - Improvements relating to collagen products - Google Patents
Improvements relating to collagen productsInfo
- Publication number
- GB1080790A GB1080790A GB50310/64A GB5031064A GB1080790A GB 1080790 A GB1080790 A GB 1080790A GB 50310/64 A GB50310/64 A GB 50310/64A GB 5031064 A GB5031064 A GB 5031064A GB 1080790 A GB1080790 A GB 1080790A
- Authority
- GB
- United Kingdom
- Prior art keywords
- collagen
- film
- belt
- fibrils
- sheets
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L17/00—Materials for surgical sutures or for ligaturing blood vessels ; Materials for prostheses or catheters
- A61L17/06—At least partially resorbable materials
- A61L17/08—At least partially resorbable materials of animal origin, e.g. catgut, collagen
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
- B29C—SHAPING OR JOINING OF PLASTICS; SHAPING OF MATERIAL IN A PLASTIC STATE, NOT OTHERWISE PROVIDED FOR; AFTER-TREATMENT OF THE SHAPED PRODUCTS, e.g. REPAIRING
- B29C48/00—Extrusion moulding, i.e. expressing the moulding material through a die or nozzle which imparts the desired form; Apparatus therefor
- B29C48/03—Extrusion moulding, i.e. expressing the moulding material through a die or nozzle which imparts the desired form; Apparatus therefor characterised by the shape of the extruded material at extrusion
- B29C48/07—Flat, e.g. panels
- B29C48/08—Flat, e.g. panels flexible, e.g. films
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
- B29C—SHAPING OR JOINING OF PLASTICS; SHAPING OF MATERIAL IN A PLASTIC STATE, NOT OTHERWISE PROVIDED FOR; AFTER-TREATMENT OF THE SHAPED PRODUCTS, e.g. REPAIRING
- B29C48/00—Extrusion moulding, i.e. expressing the moulding material through a die or nozzle which imparts the desired form; Apparatus therefor
- B29C48/25—Component parts, details or accessories; Auxiliary operations
- B29C48/88—Thermal treatment of the stream of extruded material, e.g. cooling
- B29C48/91—Heating, e.g. for cross linking
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
- B29C—SHAPING OR JOINING OF PLASTICS; SHAPING OF MATERIAL IN A PLASTIC STATE, NOT OTHERWISE PROVIDED FOR; AFTER-TREATMENT OF THE SHAPED PRODUCTS, e.g. REPAIRING
- B29C48/00—Extrusion moulding, i.e. expressing the moulding material through a die or nozzle which imparts the desired form; Apparatus therefor
- B29C48/25—Component parts, details or accessories; Auxiliary operations
- B29C48/88—Thermal treatment of the stream of extruded material, e.g. cooling
- B29C48/911—Cooling
- B29C48/9135—Cooling of flat articles, e.g. using specially adapted supporting means
- B29C48/9145—Endless cooling belts
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
- B29C—SHAPING OR JOINING OF PLASTICS; SHAPING OF MATERIAL IN A PLASTIC STATE, NOT OTHERWISE PROVIDED FOR; AFTER-TREATMENT OF THE SHAPED PRODUCTS, e.g. REPAIRING
- B29C55/00—Shaping by stretching, e.g. drawing through a die; Apparatus therefor
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
- C08L89/00—Compositions of proteins; Compositions of derivatives thereof
- C08L89/04—Products derived from waste materials, e.g. horn, hoof or hair
- C08L89/06—Products derived from waste materials, e.g. horn, hoof or hair derived from leather or skin, e.g. gelatin
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
- B29K—INDEXING SCHEME ASSOCIATED WITH SUBCLASSES B29B, B29C OR B29D, RELATING TO MOULDING MATERIALS OR TO MATERIALS FOR MOULDS, REINFORCEMENTS, FILLERS OR PREFORMED PARTS, e.g. INSERTS
- B29K2089/00—Use of proteins, e.g. casein, gelatine or derivatives thereof, as moulding material
Landscapes
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Mechanical Engineering (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Thermal Sciences (AREA)
- Physics & Mathematics (AREA)
- Materials Engineering (AREA)
- Animal Behavior & Ethology (AREA)
- Organic Chemistry (AREA)
- Polymers & Plastics (AREA)
- Surgery (AREA)
- Vascular Medicine (AREA)
- Epidemiology (AREA)
- Zoology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Dermatology (AREA)
- Materials For Medical Uses (AREA)
Abstract
1,080,790. Surgical sutures. ETHICON Inc. Dec. 10, 1964 [Dec. 12, 1963], No. 50310/ 64. Heading A5R. [Also in Division B5] A collagen film consisting essentially of collagen fibrils having throughout their entire length the typical banding at intervals of approximately 640 Angstrom units, consists of a multiplicity of extruded elongated collagen sheets disposed in parallel contiguity with respect to each other and bonded to each other along their contiguous surfaces to form a unitary laminated structure, substantially all of said fibrils having an alignment parallel to the longitudinal access of the laminated sheets which contain them and the longitudinal axis of the said sheets being parallel to the longitudinal axis of the total structure. Such films are made by causing a homogenous dispersion of swollen collagen fibrils to flow under pressure through a constricted zone, thereby imparting rectilinarity and orientation in the direction of flow to the fibrils, and extruding the dispersion of oriented collagen fibrils through a slit onto a moving belt to form a collagen film, followed by extrusion in the same manner of one or more additional collagen films onto the first formed collagen film while on said belt, the subsequently applied sheet or sheets adhering to the previously deposited sheet or sheets. Preferably, the moving belt has a polyethylene terephthalate resin surface or a polypropylene surface. After removal from the surface, the sheet may be slit to form a tape, washed, tanned and twisted to form a rounded strand of uniform circular cross-section. In apparatus as shown, a homogeneous mass of swollen collagen fibrils is moved under pressure from pumps 10, 11, 12, 13 through pipe 55 and chamber 54 (Fig. 8) of extruder heads 14, 15, 16, 17 to contricted zones 52 thereof and thence to slits 14', 15'. Constricted zones 52 are formed by the interposition of thin shims 51 between plates 49 and 50. (see also plan view of extruder head, Fig. 7, not shown). Thus a collagen film 19 is formed the thickness of which increases with each additional application of collagen. The film 19 adheres to the surface of the belt 18 and is contained by the belt through the enclosure 20 in which it is dried by moving currents of air from blowers 21, 22, heated by heaters 23. The apparatus of Fig. 1 enables successive layers of collagen to be deposited on the belt by repeated passes through the enclosure 20. The film is finally removed by the take-up roll 37. Fig. 11, (not shown) illustrates a modified extrusion head adapted to extrude a collagen film of about 18 inches in width. Construction is similar to that of Fig. 8 except for the provision of additional entry ports. Fig. 12 (not shown) is a modified form of the apparatus of Fig. 1, adapted to utilise the wide extruder head 57, the principle of operation being similar. In the Example, a laminated collagen film of about two mils thickness is made. After removal from the take-up spool the film is washed with methanol to remove cyanoacetic acid, and air-dried. The film is then cut longitudinally and the resulting tapes are then tanned, stretched, false-twisted and dried to form a uniform strand. The collagen strands so made are cut into five-foot lengths, packaged in a tubing fluid and electron beam sterilsed and are then suitable for use as surgical sutures.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US33008863A | 1963-12-12 | 1963-12-12 |
Publications (1)
Publication Number | Publication Date |
---|---|
GB1080790A true GB1080790A (en) | 1967-08-23 |
Family
ID=23288275
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
GB50310/64A Expired GB1080790A (en) | 1963-12-12 | 1964-12-10 | Improvements relating to collagen products |
Country Status (3)
Country | Link |
---|---|
DE (1) | DE1504217A1 (en) |
GB (1) | GB1080790A (en) |
SE (1) | SE327783B (en) |
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR2081832A1 (en) * | 1970-03-10 | 1971-12-10 | Robinson E S & A Ltd | |
WO2004071546A1 (en) * | 2003-02-14 | 2004-08-26 | MAX-PLANCK-Gesellschaft zur Förderung der Wissenschaften e.V. | Method of producing a collagen layer |
Families Citing this family (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE3832162A1 (en) * | 1988-09-22 | 1990-04-12 | Lohmann Therapie Syst Lts | METHOD FOR THE PRODUCTION OF COLLAGEN FOAMS IN THE FORM OF ENDLESS TAPES AND USE IN MEDICINE, COSMETICS AND HYGIENE |
-
1964
- 1964-12-10 GB GB50310/64A patent/GB1080790A/en not_active Expired
- 1964-12-10 DE DE19641504217 patent/DE1504217A1/en active Pending
- 1964-12-11 SE SE15032/64A patent/SE327783B/xx unknown
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR2081832A1 (en) * | 1970-03-10 | 1971-12-10 | Robinson E S & A Ltd | |
WO2004071546A1 (en) * | 2003-02-14 | 2004-08-26 | MAX-PLANCK-Gesellschaft zur Förderung der Wissenschaften e.V. | Method of producing a collagen layer |
Also Published As
Publication number | Publication date |
---|---|
SE327783B (en) | 1970-08-31 |
DE1504217A1 (en) | 1969-11-13 |
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