GB1074086A - Dibenzocycloheptene derivatives - Google Patents

Dibenzocycloheptene derivatives

Info

Publication number
GB1074086A
GB1074086A GB1280/67A GB128067A GB1074086A GB 1074086 A GB1074086 A GB 1074086A GB 1280/67 A GB1280/67 A GB 1280/67A GB 128067 A GB128067 A GB 128067A GB 1074086 A GB1074086 A GB 1074086A
Authority
GB
United Kingdom
Prior art keywords
alkyl
formula
atom
sulphamoyl
reaction
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB1280/67A
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merck and Co Inc
Original Assignee
Merck and Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck and Co Inc filed Critical Merck and Co Inc
Publication of GB1074086A publication Critical patent/GB1074086A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
    • C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
    • C07D493/08—Bridged systems
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D11/00—Solvent extraction
    • B01D11/02—Solvent extraction of solids
    • B01D11/0203—Solvent extraction of solids with a supercritical fluid
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D11/00—Solvent extraction
    • B01D11/04—Solvent extraction of solutions which are liquid
    • B01D11/0403—Solvent extraction of solutions which are liquid with a supercritical fluid
    • B01D11/0407—Solvent extraction of solutions which are liquid with a supercritical fluid the supercritical fluid acting as solvent for the solute
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
    • C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
    • C07D317/44—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D317/70—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems condensed with ring systems containing two or more relevant rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

The invention comprises compounds of formula <FORM:1074086/C2/1> wherein each of R4 and R5 is a hydrogen atom or an alkyl, aryl or aralkyl group, -NR1R11 is a di-(C1- 6 alkyl) amino group or a saturated heterocyclic amino group having 5 or 6 ring atoms, which may contain a second, optionally C1- 4 alkylated, nitrogen atom or an oxygen atom, each of X and X1 is a hydrogen or halogen atom or a C1- 6 alkyl, C2- 6 alkenyl, trifluoromethyl, hydroxy, C1- 4 alkoxy, mercapto, C1- 4 alkylthio, C1- 4 alkylsulphonyl, sulphamoyl, C1- 4 alkylsulphamoyl or di-(C1- 4 alkyl)-sulphamoyl group and more than one substituent may be present on each benzenoid ring, and their preparation by reaction of a compound of formula <FORM:1074086/C2/2> with a Grignard reagent of formula HalMg(CH2)3NR1R11. Cis - 3a, 12b - dihydro - 2 - phenyl - 8H - dibenzo - [3.4:6,7] cyclohepta [1,2 - d] - 1,3 - dioxolan-8-one is prepared by reaction of the corresponding 10,11-dihydroxy-dibenzocycloheptenone with benzaldehyde.
GB1280/67A 1963-06-11 1964-06-08 Dibenzocycloheptene derivatives Expired GB1074086A (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US28696263A 1963-06-11 1963-06-11
US30663963A 1963-09-04 1963-09-04
US48190865A 1965-08-23 1965-08-23

Publications (1)

Publication Number Publication Date
GB1074086A true GB1074086A (en) 1967-06-28

Family

ID=27403666

Family Applications (2)

Application Number Title Priority Date Filing Date
GB1280/67A Expired GB1074086A (en) 1963-06-11 1964-06-08 Dibenzocycloheptene derivatives
GB37077/66A Expired GB1148740A (en) 1963-06-11 1966-08-18 5,10-epoxy-5-(aminopropyl)-dibenzocycloheptenes

Family Applications After (1)

Application Number Title Priority Date Filing Date
GB37077/66A Expired GB1148740A (en) 1963-06-11 1966-08-18 5,10-epoxy-5-(aminopropyl)-dibenzocycloheptenes

Country Status (5)

Country Link
US (1) US3494935A (en)
BE (1) BE685858A (en)
DE (1) DE1543770A1 (en)
GB (2) GB1074086A (en)
NL (1) NL6611814A (en)

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BE557002A (en) * 1956-07-09
US3264342A (en) * 1963-05-24 1966-08-02 Geigy Chem Corp Derivatives of 5h-dibenzo[a, d] cycloheptene
US3258488A (en) * 1963-08-12 1966-06-28 Colgate Palmolive Co Dibenzo[a, d]cycloheptene derivatives

Also Published As

Publication number Publication date
US3494935A (en) 1970-02-10
NL6611814A (en) 1967-02-24
BE685858A (en) 1967-02-23
DE1543770A1 (en) 1969-12-18
GB1148740A (en) 1969-04-16

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