GB1070120A - Pyridoxine derivative and the preparation thereof - Google Patents
Pyridoxine derivative and the preparation thereofInfo
- Publication number
- GB1070120A GB1070120A GB2028266A GB2028266A GB1070120A GB 1070120 A GB1070120 A GB 1070120A GB 2028266 A GB2028266 A GB 2028266A GB 2028266 A GB2028266 A GB 2028266A GB 1070120 A GB1070120 A GB 1070120A
- Authority
- GB
- United Kingdom
- Prior art keywords
- nicotinoyl
- pyridoxine
- formula
- preparation
- alkylidene
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D213/79—Acids; Esters
- C07D213/80—Acids; Esters in position 3
Abstract
The invention comprises a 5-O-nicotinoyl-pyridoxine of formula <FORM:1070120/C2/1> The compound is prepared by reacting a 4,3-O-alkylidene-pyridoxine of formula <FORM:1070120/C2/2> where A is an alkylidene group having 3 to 6 carbon atoms, with a nicotinoyl halide or nicotinic anhydride to obtain a 4,3-O-alkylidene-a 5-O-nicotinoyl-pyridoxine of formula <FORM:1070120/C2/3> which is then hydrolysed to a 5-O-nicotinoyl-pyridoxine. Examples are given. a 5-O-Nicotinoyl-pyridoxide may be mixed with a physiologically acceptable carrier and used to prevent lipoidosis, e.g. arteriosclerosis or cholesterolemia.
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB2028266A GB1070120A (en) | 1966-05-06 | 1966-05-06 | Pyridoxine derivative and the preparation thereof |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB2028266A GB1070120A (en) | 1966-05-06 | 1966-05-06 | Pyridoxine derivative and the preparation thereof |
Publications (1)
Publication Number | Publication Date |
---|---|
GB1070120A true GB1070120A (en) | 1967-05-24 |
Family
ID=10143410
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
GB2028266A Expired GB1070120A (en) | 1966-05-06 | 1966-05-06 | Pyridoxine derivative and the preparation thereof |
Country Status (1)
Country | Link |
---|---|
GB (1) | GB1070120A (en) |
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0033488A1 (en) * | 1980-01-22 | 1981-08-12 | D and D S.r.l. | Therapeutically active derivatives of nicotinic acid, process for their preparation and related pharmaceutical compositions |
EP0282696A2 (en) * | 1987-02-18 | 1988-09-21 | Steigerwald Arzneimittelwerk Gmbh | Use of pyridoxine derivatives in the prophylaxis and treatment of hyperlipemia and atherosclerosis |
-
1966
- 1966-05-06 GB GB2028266A patent/GB1070120A/en not_active Expired
Cited By (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0033488A1 (en) * | 1980-01-22 | 1981-08-12 | D and D S.r.l. | Therapeutically active derivatives of nicotinic acid, process for their preparation and related pharmaceutical compositions |
EP0282696A2 (en) * | 1987-02-18 | 1988-09-21 | Steigerwald Arzneimittelwerk Gmbh | Use of pyridoxine derivatives in the prophylaxis and treatment of hyperlipemia and atherosclerosis |
EP0282696A3 (en) * | 1987-02-18 | 1989-06-14 | Ulrich Dr. Speck | Use of pyridoxine derivatives in the prophylaxis and treatment of hyperlipemia and atherosclerosis |
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