GB1063951A - A process for producing purine ribosides or deoxyribosides - Google Patents
A process for producing purine ribosides or deoxyribosidesInfo
- Publication number
- GB1063951A GB1063951A GB1127164A GB1127164A GB1063951A GB 1063951 A GB1063951 A GB 1063951A GB 1127164 A GB1127164 A GB 1127164A GB 1127164 A GB1127164 A GB 1127164A GB 1063951 A GB1063951 A GB 1063951A
- Authority
- GB
- United Kingdom
- Prior art keywords
- purine
- hydrogen
- deoxyribosides
- hydroxyl
- amino
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/16—Purine radicals
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P19/00—Preparation of compounds containing saccharide radicals
- C12P19/26—Preparation of nitrogen-containing carbohydrates
- C12P19/28—N-glycosides
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- General Health & Medical Sciences (AREA)
- Biotechnology (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Engineering & Computer Science (AREA)
- Microbiology (AREA)
- General Chemical & Material Sciences (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Saccharide Compounds (AREA)
Abstract
Compounds of the formula <FORM:1063951/C2/1> or <FORM:1063951/C2/2> in which R is ribosyl or deoxyribosyl, A is hydrogen, hydroxyl or amino, B is hydrogen, halogen, hydroxyl, amino, -SH, alkylamino of up to six carbon atoms, furfurylamino, or acylamino of up to seven carbon atoms, and X is =CH- or =N-; with the proviso that X is not =CH- when B is hydroxyl or when A is hydrogen and B is amino; are prepared by reacting the corresponding N-hydrogen compounds with a purine riboside, a purine ribotide, a purine deoxyriboside, a purine deoxyribotide, a pyrimidine deoxyriboside or a pyrimidine deoxyribotide (a purine residue if used being different from that in a purine base if used) in an aqueous medium of pH 4-10 at 25-50 DEG C. in the presence of an inorganic phosphate and a pentosyl-transferring enzyme system of an aerobic bacterium. Many suitable micro organisms are listed, and may be used as a culture broth or cell suspension or after disruption of the cells. Specified and/or exemplified products are purine, 6-mercaptopurine, 2-aminopurine, 2,6-diaminopurine, kinetin, 6-methylaminopurine, isoguanine, 6-chloropurine, 6-iodopurine, 8-azaguanine and 6-mercapto-8-azaguanine ribosides and deoxyribosides; and benzoyladenine, 8-azahypoxanthine, benzotriazole and benzimidazole deoxyribosides. Other starting bases are specified.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP1463463 | 1963-03-18 | ||
| JP1463563 | 1963-03-18 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB1063951A true GB1063951A (en) | 1967-04-05 |
Family
ID=26350618
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB1127164A Expired GB1063951A (en) | 1963-03-18 | 1964-03-17 | A process for producing purine ribosides or deoxyribosides |
Country Status (2)
| Country | Link |
|---|---|
| DE (1) | DE1470360B2 (en) |
| GB (1) | GB1063951A (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0916735A1 (en) * | 1997-11-14 | 1999-05-19 | Ajinomoto Co., Inc. | Process for preparing 2,6-diaminopurine-2'-deoxyriboside and 2'-deoxyguanosine |
-
1964
- 1964-03-17 DE DE1964T0025833 patent/DE1470360B2/en active Granted
- 1964-03-17 GB GB1127164A patent/GB1063951A/en not_active Expired
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0916735A1 (en) * | 1997-11-14 | 1999-05-19 | Ajinomoto Co., Inc. | Process for preparing 2,6-diaminopurine-2'-deoxyriboside and 2'-deoxyguanosine |
| US6197552B1 (en) | 1997-11-14 | 2001-03-06 | Ajinomoto Co., Inc. | Process for preparing 2,6-diaminopurine-2′-deoxyriboside and 2′-deoxyguanosine |
Also Published As
| Publication number | Publication date |
|---|---|
| DE1795480B2 (en) | 1976-05-13 |
| DE1795481B1 (en) | 1972-09-07 |
| DE1470360A1 (en) | 1969-11-13 |
| DE1795480A1 (en) | 1972-03-09 |
| DE1470360B2 (en) | 1976-07-15 |
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