GB1059816A - Novel intermediates useful in the synthesis of colchicine compounds, processes for their preparation, and the intermediates thus prepared - Google Patents
Novel intermediates useful in the synthesis of colchicine compounds, processes for their preparation, and the intermediates thus preparedInfo
- Publication number
- GB1059816A GB1059816A GB21741/66A GB2174166A GB1059816A GB 1059816 A GB1059816 A GB 1059816A GB 21741/66 A GB21741/66 A GB 21741/66A GB 2174166 A GB2174166 A GB 2174166A GB 1059816 A GB1059816 A GB 1059816A
- Authority
- GB
- United Kingdom
- Prior art keywords
- intermediates
- compounds
- synthesis
- processes
- prepared
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 239000000543 intermediate Substances 0.000 title 2
- IAKHMKGGTNLKSZ-INIZCTEOSA-N (S)-colchicine Chemical class C1([C@@H](NC(C)=O)CC2)=CC(=O)C(OC)=CC=C1C1=C2C=C(OC)C(OC)=C1OC IAKHMKGGTNLKSZ-INIZCTEOSA-N 0.000 title 1
- 230000015572 biosynthetic process Effects 0.000 title 1
- 238000000034 method Methods 0.000 title 1
- 238000002360 preparation method Methods 0.000 title 1
- 238000003786 synthesis reaction Methods 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 3
- JUJWROOIHBZHMG-UHFFFAOYSA-N Pyridine Chemical compound C1=CC=NC=C1 JUJWROOIHBZHMG-UHFFFAOYSA-N 0.000 abstract 2
- ZMXDDKWLCZADIW-UHFFFAOYSA-N N,N-Dimethylformamide Chemical compound CN(C)C=O ZMXDDKWLCZADIW-UHFFFAOYSA-N 0.000 abstract 1
- 229910052783 alkali metal Inorganic materials 0.000 abstract 1
- 150000001340 alkali metals Chemical class 0.000 abstract 1
- 125000003545 alkoxy group Chemical group 0.000 abstract 1
- 125000005907 alkyl ester group Chemical group 0.000 abstract 1
- VTYYLEPIZMXCLO-UHFFFAOYSA-L calcium carbonate Substances [Ca+2].[O-]C([O-])=O VTYYLEPIZMXCLO-UHFFFAOYSA-L 0.000 abstract 1
- 229910000019 calcium carbonate Inorganic materials 0.000 abstract 1
- 150000002148 esters Chemical class 0.000 abstract 1
- 150000004715 keto acids Chemical class 0.000 abstract 1
- 125000000956 methoxy group Chemical group [H]C([H])([H])O* 0.000 abstract 1
- UMJSCPRVCHMLSP-UHFFFAOYSA-N pyridine Natural products COC1=CC=CN=C1 UMJSCPRVCHMLSP-UHFFFAOYSA-N 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C59/00—Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
- C07C59/40—Unsaturated compounds
- C07C59/58—Unsaturated compounds containing ether groups, groups, groups, or groups
- C07C59/72—Unsaturated compounds containing ether groups, groups, groups, or groups containing six-membered aromatic rings and other rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C49/00—Ketones; Ketenes; Dimeric ketenes; Ketonic chelates
- C07C49/587—Unsaturated compounds containing a keto groups being part of a ring
- C07C49/753—Unsaturated compounds containing a keto groups being part of a ring containing ether groups, groups, groups, or groups
- C07C49/755—Unsaturated compounds containing a keto groups being part of a ring containing ether groups, groups, groups, or groups a keto group being part of a condensed ring system with two or three rings, at least one ring being a six-membered aromatic ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C51/00—Preparation of carboxylic acids or their salts, halides or anhydrides
- C07C51/09—Preparation of carboxylic acids or their salts, halides or anhydrides from carboxylic acid esters or lactones
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR930600A FR1363961A (fr) | 1963-04-05 | 1963-04-05 | Procédé de préparation des composés de la série de la colchicine et produits ainsi obtenus |
| FR937405A FR1372490A (fr) | 1963-04-05 | 1963-06-07 | Procédé de préparation des composés de la série de la colchicine et produits obtenus dans ce procédé |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB1059816A true GB1059816A (en) | 1967-02-22 |
Family
ID=26200657
Family Applications (6)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB21741/66A Expired GB1059816A (en) | 1963-04-05 | 1964-04-06 | Novel intermediates useful in the synthesis of colchicine compounds, processes for their preparation, and the intermediates thus prepared |
| GB42327/66A Expired GB1059817A (en) | 1963-04-05 | 1964-04-06 | Novel intermediates useful in the synthesis of colchicine compounds, processes for their preparation, and the intermediates thus prepared |
| GB42328/66A Expired GB1059818A (en) | 1963-04-05 | 1964-04-06 | Novel intermediates useful in the synthesis of colchicine compounds, processes for their preparation, and the intermediates thus prepared |
| GB21739/66A Expired GB1059814A (en) | 1963-04-05 | 1964-04-06 | Novel intermediates useful in the synthesis of colchicine compounds, processes for their preparation, and the intermediates thus prepared |
| GB14140/64A Expired GB1059811A (en) | 1963-04-05 | 1964-04-06 | Novel processes for the preparation of colchicine compounds, and the compounds thus prepared |
| GB21740/66A Expired GB1059815A (en) | 1963-04-05 | 1964-04-06 | Novel intermediates useful in the synthesis of colchicine compounds, processes for their preparation, and the intermediates thus prepared |
Family Applications After (5)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB42327/66A Expired GB1059817A (en) | 1963-04-05 | 1964-04-06 | Novel intermediates useful in the synthesis of colchicine compounds, processes for their preparation, and the intermediates thus prepared |
| GB42328/66A Expired GB1059818A (en) | 1963-04-05 | 1964-04-06 | Novel intermediates useful in the synthesis of colchicine compounds, processes for their preparation, and the intermediates thus prepared |
| GB21739/66A Expired GB1059814A (en) | 1963-04-05 | 1964-04-06 | Novel intermediates useful in the synthesis of colchicine compounds, processes for their preparation, and the intermediates thus prepared |
| GB14140/64A Expired GB1059811A (en) | 1963-04-05 | 1964-04-06 | Novel processes for the preparation of colchicine compounds, and the compounds thus prepared |
| GB21740/66A Expired GB1059815A (en) | 1963-04-05 | 1964-04-06 | Novel intermediates useful in the synthesis of colchicine compounds, processes for their preparation, and the intermediates thus prepared |
Country Status (9)
| Country | Link |
|---|---|
| US (1) | US3280151A (cg-RX-API-DMAC7.html) |
| AT (1) | AT260430B (cg-RX-API-DMAC7.html) |
| BE (1) | BE646101A (cg-RX-API-DMAC7.html) |
| CH (1) | CH441294A (cg-RX-API-DMAC7.html) |
| DE (1) | DE1221232B (cg-RX-API-DMAC7.html) |
| DK (2) | DK105036C (cg-RX-API-DMAC7.html) |
| FR (1) | FR1372490A (cg-RX-API-DMAC7.html) |
| GB (6) | GB1059816A (cg-RX-API-DMAC7.html) |
| NL (2) | NL6403610A (cg-RX-API-DMAC7.html) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| NL122631C (cg-RX-API-DMAC7.html) * | 1963-12-05 |
-
0
- NL NL121735D patent/NL121735C/xx active
-
1963
- 1963-06-07 FR FR937405A patent/FR1372490A/fr not_active Expired
-
1964
- 1964-03-31 US US356048A patent/US3280151A/en not_active Expired - Lifetime
- 1964-04-03 DE DER37610A patent/DE1221232B/de active Granted
- 1964-04-03 NL NL6403610A patent/NL6403610A/xx unknown
- 1964-04-03 AT AT293164A patent/AT260430B/de active
- 1964-04-03 CH CH424364A patent/CH441294A/fr unknown
- 1964-04-03 DK DK165964AA patent/DK105036C/da active
- 1964-04-03 BE BE646101A patent/BE646101A/xx unknown
- 1964-04-03 DK DK392465AA patent/DK109986C/da active
- 1964-04-06 GB GB21741/66A patent/GB1059816A/en not_active Expired
- 1964-04-06 GB GB42327/66A patent/GB1059817A/en not_active Expired
- 1964-04-06 GB GB42328/66A patent/GB1059818A/en not_active Expired
- 1964-04-06 GB GB21739/66A patent/GB1059814A/en not_active Expired
- 1964-04-06 GB GB14140/64A patent/GB1059811A/en not_active Expired
- 1964-04-06 GB GB21740/66A patent/GB1059815A/en not_active Expired
Also Published As
| Publication number | Publication date |
|---|---|
| DE1221232C2 (cg-RX-API-DMAC7.html) | 1967-02-16 |
| DE1221232B (de) | 1966-07-21 |
| NL6403610A (cg-RX-API-DMAC7.html) | 1964-10-06 |
| DK105036C (da) | 1966-08-08 |
| CH441294A (fr) | 1967-08-15 |
| FR1372490A (fr) | 1964-09-18 |
| US3280151A (en) | 1966-10-18 |
| GB1059814A (en) | 1967-02-22 |
| DK109986C (da) | 1968-08-19 |
| GB1059818A (en) | 1967-02-22 |
| BE646101A (cg-RX-API-DMAC7.html) | 1964-10-05 |
| AT260430B (de) | 1968-03-11 |
| NL121735C (cg-RX-API-DMAC7.html) | |
| GB1059815A (en) | 1967-02-22 |
| GB1059811A (en) | 1967-02-22 |
| GB1059817A (en) | 1967-02-22 |
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