GB1057742A - N-substituted octadecadienoic acid amides - Google Patents
N-substituted octadecadienoic acid amidesInfo
- Publication number
- GB1057742A GB1057742A GB5044/64A GB504464A GB1057742A GB 1057742 A GB1057742 A GB 1057742A GB 5044/64 A GB5044/64 A GB 5044/64A GB 504464 A GB504464 A GB 504464A GB 1057742 A GB1057742 A GB 1057742A
- Authority
- GB
- United Kingdom
- Prior art keywords
- group
- alkyl
- alkenyl
- aryl
- methyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- -1 N-substituted octadecadienoic acid amides Chemical class 0.000 title abstract 7
- 125000003342 alkenyl group Chemical group 0.000 abstract 4
- 125000000217 alkyl group Chemical group 0.000 abstract 4
- 125000003118 aryl group Chemical group 0.000 abstract 4
- 125000000753 cycloalkyl group Chemical group 0.000 abstract 4
- ADHNUPOJJCKWRT-JLXBFWJWSA-N (2e,4e)-octadeca-2,4-dienoic acid Chemical compound CCCCCCCCCCCCC\C=C\C=C\C(O)=O ADHNUPOJJCKWRT-JLXBFWJWSA-N 0.000 abstract 2
- 125000002877 alkyl aryl group Chemical group 0.000 abstract 2
- 125000005119 alkyl cycloalkyl group Chemical group 0.000 abstract 2
- 125000003710 aryl alkyl group Chemical group 0.000 abstract 2
- 125000000623 heterocyclic group Chemical group 0.000 abstract 2
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 2
- OYHQOLUKZRVURQ-IXWMQOLASA-N linoleic acid Natural products CCCCC\C=C/C\C=C\CCCCCCCC(O)=O OYHQOLUKZRVURQ-IXWMQOLASA-N 0.000 abstract 2
- 235000020778 linoleic acid Nutrition 0.000 abstract 2
- XSFBCAYKUJEGKT-HZJYTTRNSA-N (9Z,12Z)-1-(azepan-1-yl)octadeca-9,12-dien-1-one Chemical compound C(CCCCCCC\C=C/C\C=C/CCCCC)(=O)N1CCCCCC1 XSFBCAYKUJEGKT-HZJYTTRNSA-N 0.000 abstract 1
- FEPNZYVXJHQYPM-UTJQPWESSA-N (9Z,12Z)-2-(2,4,6-trimethylphenyl)octadeca-9,12-dienamide Chemical class CC1=C(C(=CC(=C1)C)C)C(C(=O)N)CCCCCC\C=C/C\C=C/CCCCC FEPNZYVXJHQYPM-UTJQPWESSA-N 0.000 abstract 1
- OYHQOLUKZRVURQ-NTGFUMLPSA-N (9Z,12Z)-9,10,12,13-tetratritiooctadeca-9,12-dienoic acid Chemical compound C(CCCCCCC\C(=C(/C\C(=C(/CCCCC)\[3H])\[3H])\[3H])\[3H])(=O)O OYHQOLUKZRVURQ-NTGFUMLPSA-N 0.000 abstract 1
- FBWMYSQUTZRHAT-HZJYTTRNSA-N (9z,12z)-octadeca-9,12-dienoyl chloride Chemical compound CCCCC\C=C/C\C=C/CCCCCCCC(Cl)=O FBWMYSQUTZRHAT-HZJYTTRNSA-N 0.000 abstract 1
- MHVDCABZXTXSCH-UHFFFAOYSA-N C(C)N(C(CCCCCCCC=C/CC=C/CCCCC)=O)C1=CC(=CC=C1)C Chemical compound C(C)N(C(CCCCCCCC=C/CC=C/CCCCC)=O)C1=CC(=CC=C1)C MHVDCABZXTXSCH-UHFFFAOYSA-N 0.000 abstract 1
- OYHQOLUKZRVURQ-HZJYTTRNSA-N Linoleic acid Chemical compound CCCCC\C=C/C\C=C/CCCCCCCC(O)=O OYHQOLUKZRVURQ-HZJYTTRNSA-N 0.000 abstract 1
- 150000001412 amines Chemical class 0.000 abstract 1
- 125000000582 cycloheptyl group Chemical group [H]C1([H])C([H])([H])C([H])([H])C([H])([H])C([H])(*)C([H])([H])C1([H])[H] 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/16—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C233/00—Carboxylic acid amides
- C07C233/01—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
- C07C233/02—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having nitrogen atoms of carboxamide groups bound to hydrogen atoms or to carbon atoms of unsubstituted hydrocarbon radicals
-
- C—CHEMISTRY; METALLURGY
- C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
- C09F—NATURAL RESINS; FRENCH POLISH; DRYING-OILS; OIL DRYING AGENTS, i.e. SICCATIVES; TURPENTINE
- C09F5/00—Obtaining drying-oils
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
The invention comprises N-cyclopentyl, cycloheptyl, 2-methyl-cyclohexyl, 3-methyl-cyclohexyl, 4-methyl-cyclohexyl, 4-t.-butyl-phenyl and 2,4,6 - trimethyl - phenyl - linoleamides, N - ethyl - N - (3 - methyl - phenyl) - linoleamide and N - linoleoyl - hexamethyleneimine, and their preparation by reaction of linoleic acid, linoleic acid chloride or a linoleic acid ester with an appropriate amine. Other octadecadienoic acid amides of formula C17H31CONRR1, wherein R is a hydrogen atom or an alkyl, alkenyl, aryl or cycloalkyl group and R1 is an alkyl, alkenyl, aryl, alkaryl, aralkyl, aralkenyl, cycloalkyl or alkylcycloalkyl group, or the group -NRR1 form a heterocycle are similarly prepared.ALSO:Pharmaceutical compositions having cholsterol lowering activity comprise, in combination with a carrier, one or more octadecadienoic acid amides of formula C17H31CONRR1, in which R is a hydrogen atom or an alkyl, alkenyl, aryl or cycloalkyl group and R1 is an alkyl, alkenyl, aryl, alkaryl, aralkyl, aralkenyl, cycloalkyl or alkylcyclo alkyl group, or the group - NRR1 forms a heterocycle. The compositions may be in forms suitable for oral administration and may also contain linoleic acid.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP631563 | 1963-02-06 | ||
| JP631463 | 1963-02-06 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB1057742A true GB1057742A (en) | 1967-02-08 |
Family
ID=26340418
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB5044/64A Expired GB1057742A (en) | 1963-02-06 | 1964-02-06 | N-substituted octadecadienoic acid amides |
Country Status (6)
| Country | Link |
|---|---|
| BE (1) | BE643451A (en) |
| CH (1) | CH438270A (en) |
| DE (1) | DE1468952B1 (en) |
| FR (1) | FR3390M (en) |
| GB (1) | GB1057742A (en) |
| SE (1) | SE306730B (en) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4751026A (en) * | 1986-03-24 | 1988-06-14 | Warner-Lambert Company | Substituted anilides of oleic, linoleic, or linolenic acid as inhibitors of acyl-coa:cholesterol acyltransferase |
| US10035970B2 (en) | 2016-05-09 | 2018-07-31 | Basf Se | Friction-reducing compound, method of producing same, and lubricant composition |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4092324A (en) * | 1971-05-22 | 1978-05-30 | Sumitomo Chemical Company, Limited | Diheterocyclic esters of 4-(1,1-bis-(phenoxy-propionic or -butoyric acid)-cyclohexane)α-methyl substituted |
| IL103932A (en) * | 1992-11-30 | 1997-02-18 | Yissum Res & Dev | Fatty acid and pharmaceutical compositions containing them |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2977318A (en) * | 1956-06-20 | 1961-03-28 | Hagan Chemicals & Controls Inc | Substituted amide inhibited acid compositions |
| NL124251C (en) * | 1962-07-16 |
-
1964
- 1964-02-04 SE SE137164A patent/SE306730B/xx unknown
- 1964-02-05 CH CH130664A patent/CH438270A/en unknown
- 1964-02-06 DE DE19641468952 patent/DE1468952B1/en active Pending
- 1964-02-06 BE BE643451D patent/BE643451A/xx unknown
- 1964-02-06 GB GB5044/64A patent/GB1057742A/en not_active Expired
- 1964-02-08 FR FR962884A patent/FR3390M/en not_active Expired
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4751026A (en) * | 1986-03-24 | 1988-06-14 | Warner-Lambert Company | Substituted anilides of oleic, linoleic, or linolenic acid as inhibitors of acyl-coa:cholesterol acyltransferase |
| US10035970B2 (en) | 2016-05-09 | 2018-07-31 | Basf Se | Friction-reducing compound, method of producing same, and lubricant composition |
Also Published As
| Publication number | Publication date |
|---|---|
| CH438270A (en) | 1967-06-30 |
| BE643451A (en) | 1964-05-29 |
| DE1468952B1 (en) | 1970-12-23 |
| SE306730B (en) | 1968-12-09 |
| FR3390M (en) | 1965-06-21 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| ATE25251T1 (en) | ANTI SRS-A CARBONIC ACID DERIVATIVES, PROCESS FOR THEIR MANUFACTURE AND PHARMACEUTICAL FORMULATIONS CONTAINING THEM. | |
| ES8301927A1 (en) | Substituted azobicyclooctanecarboxylic acids, process for their preparation und pharmaceutical compositions containing them. | |
| DE3175030D1 (en) | Derivatives of 4-aminobutyric acid and the medicines especially active on the central nervous system containing them | |
| ES8200353A1 (en) | Tetrazolyloxycarbon amides, process for their preparation and their use as herbicides. | |
| ES488644A1 (en) | 1-Allyltriazole derivatives, process for their preparation and their use as plant protecting agents. | |
| ES420258A1 (en) | Tetrahydro-1,3,5-triazine-2,6-diones | |
| GB1057742A (en) | N-substituted octadecadienoic acid amides | |
| ES337254A1 (en) | Process for control of algae growth using compositions containing diamines and/or derivatives thereof | |
| GB1348422A (en) | Compositions for regulating plant growth containing quaternary ammonium salts | |
| GB1353399A (en) | N,n-disubstituted amidoximes and their derivatives | |
| GB1168819A (en) | Processes for the Production of Halogenated Phosphorus Esters | |
| BG101501A (en) | Nitro-benzamides useful as anti-arrhytmic agents | |
| ES386846A1 (en) | Hydroxamic acid derivatives of alphaaminooxy carboxylic acids | |
| FI842739A0 (en) | FOERFARANDE FOER FRAMSTAELLNING AV BIOLOGISKT AKTIVA HEPTAPEPTIDER. | |
| GB1087578A (en) | Substituted amides | |
| ES403080A1 (en) | Aminothiophene-carboxylic acid esters | |
| ES451209A1 (en) | Antispasmodic substituted sulphoximides | |
| ES386847A1 (en) | Amino-oxy carboxylic acid amides | |
| ES424850A1 (en) | S-(N-methyl-N-phenyl-carbamoylmethyl) esters of certain thiophosphonic and dithiophosphonic acids | |
| ES535903A0 (en) | PROCEDURE FOR THE PREPARATION OF DERIVATIVES OF NITROSOUREAS | |
| ES435422A1 (en) | Fungicidal compositions containing disubstituted phosphonates | |
| ES393554A1 (en) | Thiazole derivatives and a process for the manufacture thereof | |
| GB1042199A (en) | Certain substituted ª-alkyl and ª-cycloalkylamino-propionamides | |
| GB997043A (en) | Derivatives of 1,5-diarylpyrrole-2-propionic acid | |
| ES357236A1 (en) | Esters derived from 5-nitro quinaldine |