GB1053307A - - Google Patents

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Publication number
GB1053307A
GB1053307A GB1053307DA GB1053307A GB 1053307 A GB1053307 A GB 1053307A GB 1053307D A GB1053307D A GB 1053307DA GB 1053307 A GB1053307 A GB 1053307A
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formula
compounds
alkyl
group
prepared
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Publication of GB1053307A publication Critical patent/GB1053307A/en
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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients

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  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

1,053,307. 1-Hydroxy-1,2-dihydro-1,3,5-triazines. UPJOHN CO. Feb. 26, 1964 [April 16. 1963], No. 8020/64. Heading C2C. The invention comprises compounds of the Formula I and their acid addition salts, wherein R 1 represents a hydrogen atom or a C 1-4 alkyl group, R 2 represents a hydrogen atom or a C 1-4 alkyl or piperidino group and R 3 represents a C 2-8 dialkylamino, dibenzylamino or bis-(2- hydroxypropyl) amino group or an N-aziridinyl, N-azetidinyl, N-pyrrolidinyl, piperidino, N- hexahydroazepinyl, heptamethyleneimino, oc. tamethyleneimino or morpholino group, each of the above heterocyclic radicals having optionally attached thereto 1 to 3 C 1-8 alkyl radicals, and compounds of the Formula IV wherein R 8 represents a C 2-8 alkenyl radical, R 9 represents a C 1-8 alkyl radical or a C 2-8 alkenyl radical and R 6 and R 7 represent C 1-4 alkyl or C 2-4 alkenyl radicals. Compounds of the Formulae I and IV are prepared by mixing triazines of the Formulae II and V respectively with a compound of the Formula III wherein X represents a halogen atom or a C 1-8 alkyl, C 1-8 alkoxy, or nitro group and n represents 0 to 5. Compounds of the Formula I wherein R 3 represents a C 2-16 dialkylamino group are prepared by hydrogenating compounds of the Formula IV in the presence of a hydrogenation catalyst. Compounds of the Formula I wherein R 1 and R 2 represent hydrogen atoms are prepared by reacting a cyanoguanidine of the Formula R 3 -C(: NH)NHCN with cyanogen bromide in the presence of a strong base and reacting the resulting dicyanoguanidine salt with a hydroxylamine acid addition salt. Triazines of the Formulae II and V may be prepared from cyanuric chloride by appropriate replacement of the three chlorine atoms by primary, secondary and tertiary amino groups. Therapeutic compositions with anti-hypertensive, vasodilatory, antisecretory and central nervous system depressant properties in the forms of tablets, capsules, powders, pills, granules, syrups, elixirs, suppositories, solutions, and dispersions, for oral, topical and parenteral application, comprise compounds of the Formula I and acid addition salts thereof together with a pharmaceutically acceptable carrier.
GB1053307D 1963-04-16 Active GB1053307A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US27328163A 1963-04-16 1963-04-16

Publications (1)

Publication Number Publication Date
GB1053307A true GB1053307A (en)

Family

ID=23043284

Family Applications (1)

Application Number Title Priority Date Filing Date
GB1053307D Active GB1053307A (en) 1963-04-16

Country Status (5)

Country Link
CH (1) CH459242A (en)
DE (1) DE1245973B (en)
FR (1) FR1559565A (en)
GB (1) GB1053307A (en)
NL (1) NL6404152A (en)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5300503A (en) * 1991-11-01 1994-04-05 Fmc Corporation Insecticidal 4,6-diamino-1,2-dihydro-1,3,5-triazine derivatives
US5502054A (en) * 1994-08-11 1996-03-26 Fmc Corporation 6-substituted-3,5-diamino-1,2,4-triazines as insecticides

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE19514318A1 (en) * 1995-04-18 1996-10-24 Hoechst Ag Formaldehyde-free crosslinkers for paint binders

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5300503A (en) * 1991-11-01 1994-04-05 Fmc Corporation Insecticidal 4,6-diamino-1,2-dihydro-1,3,5-triazine derivatives
US5502054A (en) * 1994-08-11 1996-03-26 Fmc Corporation 6-substituted-3,5-diamino-1,2,4-triazines as insecticides

Also Published As

Publication number Publication date
DE1245973B (en) 1967-08-03
CH459242A (en) 1968-07-15
NL6404152A (en) 1964-10-19
FR1559565A (en) 1969-03-14

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