GB1053204A - - Google Patents
Info
- Publication number
- GB1053204A GB1053204A GB1053204DA GB1053204A GB 1053204 A GB1053204 A GB 1053204A GB 1053204D A GB1053204D A GB 1053204DA GB 1053204 A GB1053204 A GB 1053204A
- Authority
- GB
- United Kingdom
- Prior art keywords
- radical
- alkyl
- carbamido
- sulphonamides
- oct
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 abstract 4
- XEEYBQQBJWHFJM-UHFFFAOYSA-N Iron Chemical compound [Fe] XEEYBQQBJWHFJM-UHFFFAOYSA-N 0.000 abstract 4
- -1 amino compound Chemical class 0.000 abstract 4
- 125000000217 alkyl group Chemical group 0.000 abstract 3
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 2
- 125000002795 guanidino group Chemical group C(N)(=N)N* 0.000 abstract 2
- 229910052739 hydrogen Inorganic materials 0.000 abstract 2
- 239000001257 hydrogen Substances 0.000 abstract 2
- 229910052742 iron Inorganic materials 0.000 abstract 2
- 150000003456 sulfonamides Chemical class 0.000 abstract 2
- TXUICONDJPYNPY-UHFFFAOYSA-N (1,10,13-trimethyl-3-oxo-4,5,6,7,8,9,11,12,14,15,16,17-dodecahydrocyclopenta[a]phenanthren-17-yl) heptanoate Chemical compound C1CC2CC(=O)C=C(C)C2(C)C2C1C1CCC(OC(=O)CCCCCC)C1(C)CC2 TXUICONDJPYNPY-UHFFFAOYSA-N 0.000 abstract 1
- 229910021626 Tin(II) chloride Inorganic materials 0.000 abstract 1
- 125000000738 acetamido group Chemical group [H]C([H])([H])C(=O)N([H])[*] 0.000 abstract 1
- 125000004442 acylamino group Chemical group 0.000 abstract 1
- 125000004448 alkyl carbonyl group Chemical group 0.000 abstract 1
- 125000004390 alkyl sulfonyl group Chemical group 0.000 abstract 1
- 125000002947 alkylene group Chemical group 0.000 abstract 1
- 125000004391 aryl sulfonyl group Chemical group 0.000 abstract 1
- 150000007514 bases Chemical class 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 125000000753 cycloalkyl group Chemical group 0.000 abstract 1
- 125000005843 halogen group Chemical group 0.000 abstract 1
- 125000005842 heteroatom Chemical group 0.000 abstract 1
- 125000000623 heterocyclic group Chemical group 0.000 abstract 1
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 abstract 1
- QJGQUHMNIGDVPM-UHFFFAOYSA-N nitrogen group Chemical group [N] QJGQUHMNIGDVPM-UHFFFAOYSA-N 0.000 abstract 1
- 150000007530 organic bases Chemical class 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 239000001119 stannous chloride Substances 0.000 abstract 1
- 235000011150 stannous chloride Nutrition 0.000 abstract 1
- 125000001424 substituent group Chemical group 0.000 abstract 1
- YBBRCQOCSYXUOC-UHFFFAOYSA-N sulfuryl dichloride Chemical compound ClS(Cl)(=O)=O YBBRCQOCSYXUOC-UHFFFAOYSA-N 0.000 abstract 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 abstract 1
- 229910001868 water Inorganic materials 0.000 abstract 1
Landscapes
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
1,053,204. Sulphonamides. MERCK & CO. Inc. Oct. 18, 1963 [Oct. 20, 1962; Dec. 21, 1962; Feb. 26, 1963], Nos. 39773/62, 48278/62 and 7571/63. Heading C2C. The invention comprises sulphonamides of the formula wherein X is a halogen atom or an alkyl or halogen-substituted alkyl radical e.g. Cl, Br, CF 3 , R 1 is hydrogen or an alkyl or alkylol radical and R 2 is an alkyl, cycloalkyl, alkylol alkylcarbonyl, alkylsulphonyl, aralkylsulphonyl arylsulphonyl or dialkylaminoalkyl radical or R 1 and R 2 together with the nitrogen form a heterocyclic ring which may bear substituents and may also contain other hetero atoms; and in the case of basic compounds, the salts thereof. It comprises also the preparation of these compounds by reacting the corresponding sulphonyl chloride with an organic base of the formula R 1 .NH.R 2 , and if Y is a nitro group, reducing the product, if desired, e.g. with iron and water, iron and hydrochloric acid or stannous chloride and hydrochloric acid, to give the corresponding amino compound. Suitably NR 1 R 2 is a methylsulphonamido, diethylamino, 4 - methylpiperazino, cyclopropylamino, heptamethyleneimino, diethylaminoethylamino, or acetamido group. In the Provisional Specifications Y may also be an acylamino, alkylideneamino, guanidino, carbamido or substituted guanidino or carbamido radical, R, may also be alkylene and R 2 may also be hydrogen.
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB1053204A true GB1053204A (en) |
Family
ID=1757412
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB1053204D Active GB1053204A (en) |
Country Status (1)
| Country | Link |
|---|---|
| GB (1) | GB1053204A (en) |
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4665227A (en) * | 1986-05-23 | 1987-05-12 | American Home Products Corporation | N-substituted-4(3)-nitrobenzene sulphonamides |
| US4698445A (en) * | 1986-06-18 | 1987-10-06 | American Home Products Corporation | 4-amino benzenesulfonamides |
| US4721809A (en) * | 1986-09-18 | 1988-01-26 | American Home Products Corporation | Alkylsulfonamido or perfluoroalkylsulfonamido benzenesulfonamides |
| US4794196A (en) * | 1987-02-10 | 1988-12-27 | American Home Products Corporation | N-aminoalkylperfluoroalkanoylaminobenzene-sulfonamide anti-arrhythmic agents |
| US4897423A (en) * | 1988-08-02 | 1990-01-30 | Merck & Co. Inc. | Dinitrobenzenesulfonamides |
-
0
- GB GB1053204D patent/GB1053204A/en active Active
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4665227A (en) * | 1986-05-23 | 1987-05-12 | American Home Products Corporation | N-substituted-4(3)-nitrobenzene sulphonamides |
| US4698445A (en) * | 1986-06-18 | 1987-10-06 | American Home Products Corporation | 4-amino benzenesulfonamides |
| US4721809A (en) * | 1986-09-18 | 1988-01-26 | American Home Products Corporation | Alkylsulfonamido or perfluoroalkylsulfonamido benzenesulfonamides |
| US4794196A (en) * | 1987-02-10 | 1988-12-27 | American Home Products Corporation | N-aminoalkylperfluoroalkanoylaminobenzene-sulfonamide anti-arrhythmic agents |
| US4897423A (en) * | 1988-08-02 | 1990-01-30 | Merck & Co. Inc. | Dinitrobenzenesulfonamides |
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