GB1050422A - - Google Patents
Info
- Publication number
- GB1050422A GB1050422A GB1050422DA GB1050422A GB 1050422 A GB1050422 A GB 1050422A GB 1050422D A GB1050422D A GB 1050422DA GB 1050422 A GB1050422 A GB 1050422A
- Authority
- GB
- United Kingdom
- Prior art keywords
- adamant
- oxy
- penicillins
- acid
- penicillin
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
- 229930182555 Penicillin Natural products 0.000 abstract 7
- -1 methylene dioxy Chemical group 0.000 abstract 6
- 150000002960 penicillins Chemical class 0.000 abstract 4
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 abstract 3
- 125000000217 alkyl group Chemical group 0.000 abstract 3
- 229940049954 penicillin Drugs 0.000 abstract 3
- 150000003839 salts Chemical class 0.000 abstract 3
- JGSARLDLIJGVTE-MBNYWOFBSA-N Penicillin G Chemical compound N([C@H]1[C@H]2SC([C@@H](N2C1=O)C(O)=O)(C)C)C(=O)CC1=CC=CC=C1 JGSARLDLIJGVTE-MBNYWOFBSA-N 0.000 abstract 2
- 239000002253 acid Substances 0.000 abstract 2
- 150000008064 anhydrides Chemical class 0.000 abstract 2
- RYNSYNZPEBDAAA-UHFFFAOYSA-N 2-(1-adamantyloxy)acetic acid Chemical compound C1C(C2)CC3CC2CC1(OCC(=O)O)C3 RYNSYNZPEBDAAA-UHFFFAOYSA-N 0.000 abstract 1
- QLNGGPOWEFTUPO-UHFFFAOYSA-N 2-(1-adamantyloxy)propanoic acid Chemical compound C1C(C2)CC3CC2CC1(OC(C)C(O)=O)C3 QLNGGPOWEFTUPO-UHFFFAOYSA-N 0.000 abstract 1
- NGHVIOIJCVXTGV-ALEPSDHESA-N 6-aminopenicillanic acid Chemical compound [O-]C(=O)[C@H]1C(C)(C)S[C@@H]2[C@H]([NH3+])C(=O)N21 NGHVIOIJCVXTGV-ALEPSDHESA-N 0.000 abstract 1
- NGHVIOIJCVXTGV-UHFFFAOYSA-N 6beta-amino-penicillanic acid Natural products OC(=O)C1C(C)(C)SC2C(N)C(=O)N21 NGHVIOIJCVXTGV-UHFFFAOYSA-N 0.000 abstract 1
- 229910001573 adamantine Inorganic materials 0.000 abstract 1
- 125000003342 alkenyl group Chemical group 0.000 abstract 1
- 125000003545 alkoxy group Chemical group 0.000 abstract 1
- 230000000844 anti-bacterial effect Effects 0.000 abstract 1
- 125000003710 aryl alkyl group Chemical group 0.000 abstract 1
- 150000001540 azides Chemical class 0.000 abstract 1
- 239000011230 binding agent Substances 0.000 abstract 1
- YZASGNFVLBJELD-UHFFFAOYSA-N butyl 2-(1-adamantyloxy)acetate Chemical compound C(CCC)OC(COC12CC3CC(CC(C1)C3)C2)=O YZASGNFVLBJELD-UHFFFAOYSA-N 0.000 abstract 1
- VFGRALUHHHDIQI-UHFFFAOYSA-N butyl 2-hydroxyacetate Chemical compound CCCCOC(=O)CO VFGRALUHHHDIQI-UHFFFAOYSA-N 0.000 abstract 1
- 125000004432 carbon atom Chemical group C* 0.000 abstract 1
- 125000000392 cycloalkenyl group Chemical group 0.000 abstract 1
- 125000000753 cycloalkyl group Chemical group 0.000 abstract 1
- 239000003937 drug carrier Substances 0.000 abstract 1
- 150000004820 halides Chemical class 0.000 abstract 1
- 229910052736 halogen Inorganic materials 0.000 abstract 1
- 150000002367 halogens Chemical class 0.000 abstract 1
- 150000007529 inorganic bases Chemical class 0.000 abstract 1
- 150000007530 organic bases Chemical class 0.000 abstract 1
- 235000019371 penicillin G benzathine Nutrition 0.000 abstract 1
- 229940056360 penicillin g Drugs 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 abstract 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D499/00—Heterocyclic compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. penicillins, penems; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C51/00—Preparation of carboxylic acids or their salts, halides or anhydrides
- C07C51/42—Separation; Purification; Stabilisation; Use of additives
- C07C51/487—Separation; Purification; Stabilisation; Use of additives by treatment giving rise to chemical modification
- C07C51/493—Separation; Purification; Stabilisation; Use of additives by treatment giving rise to chemical modification whereby carboxylic acid esters are formed
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C59/00—Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
- C07C59/125—Saturated compounds having only one carboxyl group and containing ether groups, groups, groups, or groups
- C07C59/13—Saturated compounds having only one carboxyl group and containing ether groups, groups, groups, or groups containing rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C59/00—Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
- C07C59/40—Unsaturated compounds
- C07C59/58—Unsaturated compounds containing ether groups, groups, groups, or groups
- C07C59/72—Unsaturated compounds containing ether groups, groups, groups, or groups containing six-membered aromatic rings and other rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C61/00—Compounds having carboxyl groups bound to carbon atoms of rings other than six-membered aromatic rings
- C07C61/12—Saturated polycyclic compounds
- C07C61/125—Saturated polycyclic compounds having a carboxyl group bound to a condensed ring system
- C07C61/13—Saturated polycyclic compounds having a carboxyl group bound to a condensed ring system having two rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C62/00—Compounds having carboxyl groups bound to carbon atoms of rings other than six—membered aromatic rings and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
- C07C62/02—Saturated compounds containing hydroxy or O-metal groups
- C07C62/06—Saturated compounds containing hydroxy or O-metal groups polycyclic
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C62/00—Compounds having carboxyl groups bound to carbon atoms of rings other than six—membered aromatic rings and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
- C07C62/08—Saturated compounds containing ether groups, groups, groups, or groups
- C07C62/12—Saturated compounds containing ether groups, groups, groups, or groups polycyclic
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CH285563A CH417596A (de) | 1963-03-06 | 1963-03-06 | Verfahren zur Herstellung von neuen Derivaten der 6-Amino-penicillansäure |
| CH285463A CH420127A (de) | 1963-03-06 | 1963-03-06 | Verfahren zur Herstellung von neuen Derivaten von a-Hydroxycarbonsäuren |
| CH1156064 | 1964-09-04 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB1050422A true GB1050422A (enExample) |
Family
ID=27173977
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB1050422D Active GB1050422A (enExample) | 1963-03-06 | ||
| GB9295/64A Expired GB1028237A (en) | 1963-03-06 | 1964-03-05 | Alpha-adamantanoxy carboxylic acid and derivatives |
| GB37649/65A Expired GB1122410A (en) | 1963-03-06 | 1965-09-03 | Pharmaceutical compositions comprising adamantane derivatives |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB9295/64A Expired GB1028237A (en) | 1963-03-06 | 1964-03-05 | Alpha-adamantanoxy carboxylic acid and derivatives |
| GB37649/65A Expired GB1122410A (en) | 1963-03-06 | 1965-09-03 | Pharmaceutical compositions comprising adamantane derivatives |
Country Status (10)
| Country | Link |
|---|---|
| US (1) | US3372157A (enExample) |
| BE (3) | BE644741A (enExample) |
| BR (1) | BR6457342D0 (enExample) |
| CH (2) | CH417596A (enExample) |
| DE (1) | DE1443949B1 (enExample) |
| DK (1) | DK111957B (enExample) |
| FR (2) | FR3435M (enExample) |
| GB (3) | GB1028237A (enExample) |
| NL (2) | NL125667C (enExample) |
| SE (2) | SE322515B (enExample) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3485819A (en) * | 1968-07-02 | 1969-12-23 | Squibb & Sons Inc | Alpha-amino-cyclohexadienylalkylene-penicillins and cephalosporins |
| LU80207A1 (de) * | 1978-09-07 | 1980-04-21 | H Kalbacher | Neue substituierte kohlensaeureester und urethane,verfahren zu ihrer herstellung und deren verwendung |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2348710A (en) * | 1940-11-06 | 1944-05-16 | American Cyanamid Co | Alicyclic esters of alpha-hydroxyisobutyric acids |
| US2435828A (en) * | 1944-09-27 | 1948-02-10 | J B Williams Company | Alpha-hydroxy-ether of fatty acid |
| BE615267A (fr) * | 1961-03-24 | 1962-09-19 | Rhone Poulenc Sa | Nouveau dérivé de l'adamantane et son procédé de préparation |
| DE1197880B (de) * | 1961-03-24 | 1965-08-05 | Rhone Poulenc Sa | Verfahren zur Herstellung der choleretisch wirksamen 3-[Adamantyl-(1')-oxy]-propionsaeure |
-
0
- GB GB1050422D patent/GB1050422A/en active Active
-
1963
- 1963-03-06 CH CH285563A patent/CH417596A/de unknown
- 1963-03-06 CH CH285463A patent/CH420127A/de unknown
-
1964
- 1964-03-05 NL NL6402243A patent/NL125667C/xx active
- 1964-03-05 SE SE2758/64A patent/SE322515B/xx unknown
- 1964-03-05 NL NL6402235A patent/NL6402235A/xx unknown
- 1964-03-05 SE SE2757/64A patent/SE309417B/xx unknown
- 1964-03-05 GB GB9295/64A patent/GB1028237A/en not_active Expired
- 1964-03-05 BR BR157342/64A patent/BR6457342D0/pt unknown
- 1964-03-05 BE BE644741D patent/BE644741A/xx unknown
- 1964-03-05 DK DK110764AA patent/DK111957B/da unknown
- 1964-03-05 DE DE19641443949 patent/DE1443949B1/de active Pending
- 1964-03-05 BE BE644763D patent/BE644763A/xx unknown
- 1964-06-04 FR FR977018A patent/FR3435M/fr active Active
-
1965
- 1965-07-08 US US470604A patent/US3372157A/en not_active Expired - Lifetime
- 1965-09-03 GB GB37649/65A patent/GB1122410A/en not_active Expired
- 1965-09-03 FR FR30353A patent/FR4595M/fr not_active Expired
- 1965-09-06 BE BE669218D patent/BE669218A/xx unknown
Also Published As
| Publication number | Publication date |
|---|---|
| SE309417B (enExample) | 1969-03-24 |
| NL6402243A (enExample) | 1964-09-07 |
| BE644763A (enExample) | 1964-09-07 |
| GB1122410A (en) | 1968-08-07 |
| SE322515B (enExample) | 1970-04-13 |
| FR4595M (enExample) | 1966-11-14 |
| BR6457342D0 (pt) | 1973-07-17 |
| GB1028237A (en) | 1966-05-04 |
| NL6402235A (enExample) | 1964-09-07 |
| CH417596A (de) | 1966-07-31 |
| FR3435M (fr) | 1965-07-19 |
| US3372157A (en) | 1968-03-05 |
| CH420127A (de) | 1966-09-15 |
| BE669218A (enExample) | 1966-03-07 |
| NL125667C (enExample) | 1968-07-15 |
| BE644741A (enExample) | 1964-09-07 |
| DK111957B (da) | 1968-10-28 |
| DE1443949B1 (de) | 1970-05-14 |
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