GB1049322A - Method for the preparation of 7-sulphamyl-3,4-dihydro-1,2,4-benzothiadiazine-1,1-dioxides - Google Patents

Method for the preparation of 7-sulphamyl-3,4-dihydro-1,2,4-benzothiadiazine-1,1-dioxides

Info

Publication number
GB1049322A
GB1049322A GB1560163A GB1560163A GB1049322A GB 1049322 A GB1049322 A GB 1049322A GB 1560163 A GB1560163 A GB 1560163A GB 1560163 A GB1560163 A GB 1560163A GB 1049322 A GB1049322 A GB 1049322A
Authority
GB
United Kingdom
Prior art keywords
alkyl
dioxides
dihydro
sulphamyl
benzothiadiazine
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB1560163A
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Individual
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Publication of GB1049322A publication Critical patent/GB1049322A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D285/00—Heterocyclic compounds containing rings having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by groups C07D275/00 - C07D283/00
    • C07D285/15—Six-membered rings
    • C07D285/16—Thiadiazines; Hydrogenated thiadiazines
    • C07D285/18—1,2,4-Thiadiazines; Hydrogenated 1,2,4-thiadiazines
    • C07D285/20—1,2,4-Thiadiazines; Hydrogenated 1,2,4-thiadiazines condensed with carbocyclic rings or ring systems
    • C07D285/22—1,2,4-Thiadiazines; Hydrogenated 1,2,4-thiadiazines condensed with carbocyclic rings or ring systems condensed with one six-membered ring
    • C07D285/24—1,2,4-Thiadiazines; Hydrogenated 1,2,4-thiadiazines condensed with carbocyclic rings or ring systems condensed with one six-membered ring with oxygen atoms directly attached to the ring sulfur atom
    • C07D285/26—1,2,4-Thiadiazines; Hydrogenated 1,2,4-thiadiazines condensed with carbocyclic rings or ring systems condensed with one six-membered ring with oxygen atoms directly attached to the ring sulfur atom substituted in position 6 or 7 by sulfamoyl or substituted sulfamoyl radicals
    • C07D285/28—1,2,4-Thiadiazines; Hydrogenated 1,2,4-thiadiazines condensed with carbocyclic rings or ring systems condensed with one six-membered ring with oxygen atoms directly attached to the ring sulfur atom substituted in position 6 or 7 by sulfamoyl or substituted sulfamoyl radicals with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, directly attached in position 3

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)

Abstract

7 - Sulphamoyl - 3,4 - dihydro - 1,2,4 -benzothiadizine-1,1-dioxides of the formula <FORM:1049322/C2/1> in which R is H, CH3, C2H5, halogen or a haloalkyl group, R1 and R4 are each H or C1- 3 alkyl and R2 and R3 are each H or a C1- 4 alkyl, substituted or unsubstituted aryl or a cycloalkyl group, are prepared by heating an appropriate 2,4-disulphamoyl aniline, in water or aqueous alcohol at the boiling-point of the solvent, in the presence of ammonia or a substance such as ammonium carbonate which releases ammonia, with an aldehyde of the formula R2(R3)CH.CHO. Suitably, R is Cl, Br, F or CF3 and one of R2 and R3 is an alkyl, phenylalkyl, cyclopentyl or cyclohexyl group. Reference has been directed by the Comptroller to Specifications 861,367, 863,474 876,755, 877,552 and 885,078.
GB1560163A 1962-04-19 1963-04-19 Method for the preparation of 7-sulphamyl-3,4-dihydro-1,2,4-benzothiadiazine-1,1-dioxides Expired GB1049322A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DEK0046520 1962-04-19

Publications (1)

Publication Number Publication Date
GB1049322A true GB1049322A (en) 1966-11-23

Family

ID=7224228

Family Applications (1)

Application Number Title Priority Date Filing Date
GB1560163A Expired GB1049322A (en) 1962-04-19 1963-04-19 Method for the preparation of 7-sulphamyl-3,4-dihydro-1,2,4-benzothiadiazine-1,1-dioxides

Country Status (5)

Country Link
AT (1) AT254877B (en)
CH (1) CH475269A (en)
GB (1) GB1049322A (en)
NO (1) NO118436B (en)
SE (1) SE325897B (en)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1999042456A2 (en) * 1998-02-18 1999-08-26 Neurosearch A/S Novel compounds and their use as positive ampa receptor modulators
US6943159B1 (en) 1998-02-18 2005-09-13 Neurosearch A/S Compounds and their use as positive AMPA receptor modulators

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1999042456A2 (en) * 1998-02-18 1999-08-26 Neurosearch A/S Novel compounds and their use as positive ampa receptor modulators
WO1999042456A3 (en) * 1998-02-18 1999-10-07 Neurosearch As Novel compounds and their use as positive ampa receptor modulators
US6943159B1 (en) 1998-02-18 2005-09-13 Neurosearch A/S Compounds and their use as positive AMPA receptor modulators
US7235548B2 (en) 1998-02-18 2007-06-26 Neurosearch A/S Compounds and their use as positive AMPA receptor modulators

Also Published As

Publication number Publication date
AT254877B (en) 1967-06-12
NO118436B (en) 1969-12-29
SE325897B (en) 1970-07-13
CH475269A (en) 1969-07-15

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