GB1047267A - - Google Patents

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Publication number
GB1047267A
GB1047267A GB1047267DA GB1047267A GB 1047267 A GB1047267 A GB 1047267A GB 1047267D A GB1047267D A GB 1047267DA GB 1047267 A GB1047267 A GB 1047267A
Authority
GB
United Kingdom
Prior art keywords
compounds
cis
reaction scheme
following reaction
prepared according
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Publication of GB1047267A publication Critical patent/GB1047267A/en
Active legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C59/00—Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
    • C07C59/40—Unsaturated compounds
    • C07C59/58—Unsaturated compounds containing ether groups, groups, groups, or groups
    • C07C59/64—Unsaturated compounds containing ether groups, groups, groups, or groups containing six-membered aromatic rings
    • C07C59/66—Unsaturated compounds containing ether groups, groups, groups, or groups containing six-membered aromatic rings the non-carboxylic part of the ether containing six-membered aromatic rings
    • C07C59/68—Unsaturated compounds containing ether groups, groups, groups, or groups containing six-membered aromatic rings the non-carboxylic part of the ether containing six-membered aromatic rings the oxygen atom of the ether group being bound to a non-condensed six-membered aromatic ring

Abstract

1,047,267. Amino acids. SMITH KLINE & FRENCH LABORATORIES. May 12, 1964 [May 16, 1963], No. 19802/64. Heading C2C. The invention comprises compounds of the formula wherein each of R 1 , R 2 and R 3 is hydrogen, hydroxyl, C 1-6 alkyl, C 1-6 alkoxy, benzyloxy, chloro, fluoro, bromo or trifluoromethyl, and pharmaceutically acceptable acid addition, alkali metal and alkaline earth metal salts thereof. The compounds exist in either the cis or trans configuration, both configurations having d- and l-isomers. The trans compounds are prepared according to the following reaction scheme: and the cis compounds are prepared according to the following reaction scheme: in which B represents an alkyl group. Compounds in which any of R 1 , R 2 and R 3 represents a hydroxy group may be prepared by replacement of the benzyl group by a hydrogen atom in the corresponding benzyloxy compounds. Pharmaceutical compositions for oral administration, having hypotensive activity, comprise a compound of the invention together with a pharmaceutical carrier. The compositions may be in the form of tablets, capsules, sustained release preparations, solutions or suspensions..
GB1047267D 1963-05-16 Active GB1047267A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US281037A US3313842A (en) 1963-05-16 1963-05-16 Phenylcyclopropane carboxylic acids and esters

Publications (1)

Publication Number Publication Date
GB1047267A true GB1047267A (en)

Family

ID=23075695

Family Applications (2)

Application Number Title Priority Date Filing Date
GB1047267D Active GB1047267A (en) 1963-05-16
GB1047268D Active GB1047268A (en) 1963-05-16

Family Applications After (1)

Application Number Title Priority Date Filing Date
GB1047268D Active GB1047268A (en) 1963-05-16

Country Status (4)

Country Link
US (1) US3313842A (en)
BE (1) BE648020A (en)
FR (1) FR3520M (en)
GB (2) GB1047268A (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0025141A1 (en) * 1979-09-06 1981-03-18 Bayer Ag Process for the production of 1-amino-cyclopropane-carboxylic acid and its derivatives

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4954158A (en) * 1983-08-16 1990-09-04 University Of Georgia Research Foundation, Inc. 2,3-methanoproline
CN1901971A (en) * 2003-12-15 2007-01-24 日本烟草产业株式会社 Cyclopropane compounds and pharmaceutical use thereof
CA2549598A1 (en) * 2003-12-15 2005-06-30 Japan Tobacco Inc. N-substituted-n-sulfonylaminocyclopropane compounds and pharmaceutical use thereof

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3050559A (en) * 1962-08-21 Substituted phenylcyclopropylamjnes
US3068283A (en) * 1960-12-05 1962-12-11 Smith Kline French Lab (2-phenylcyclopropyl)-ureas, and 2-phenylcyclopropylcarbamoylamines

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0025141A1 (en) * 1979-09-06 1981-03-18 Bayer Ag Process for the production of 1-amino-cyclopropane-carboxylic acid and its derivatives

Also Published As

Publication number Publication date
GB1047268A (en)
BE648020A (en) 1964-11-16
FR3520M (en) 1965-09-06
US3313842A (en) 1967-04-11

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