GB1042481A - Dipeptide derivatives - Google Patents

Dipeptide derivatives

Info

Publication number
GB1042481A
GB1042481A GB2634964A GB2634964A GB1042481A GB 1042481 A GB1042481 A GB 1042481A GB 2634964 A GB2634964 A GB 2634964A GB 2634964 A GB2634964 A GB 2634964A GB 1042481 A GB1042481 A GB 1042481A
Authority
GB
United Kingdom
Prior art keywords
compounds
acid
derivative
formation
dipeptide derivatives
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB2634964A
Inventor
John Selwyn Morley
George Wallace Kenner
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Imperial Chemical Industries Ltd
Original Assignee
Imperial Chemical Industries Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Imperial Chemical Industries Ltd filed Critical Imperial Chemical Industries Ltd
Priority to GB2634964A priority Critical patent/GB1042481A/en
Publication of GB1042481A publication Critical patent/GB1042481A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06104—Dipeptides with the first amino acid being acidic
    • C07K5/06113—Asp- or Asn-amino acid
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C271/00—Derivatives of carbamic acids, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
    • C07C271/06—Esters of carbamic acids
    • C07C271/08—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms
    • C07C271/10—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms
    • C07C271/22—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms to carbon atoms of hydrocarbon radicals substituted by carboxyl groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Peptides Or Proteins (AREA)
  • Pyrrole Compounds (AREA)

Abstract

The invention comprises compounds of the formula <FORM:1042481/C2/1> where R is an alkyl or aralkyl radical. The compounds are prepared by activating the carboxyl function of the corresponding b -esters of N-benzyloxy carbonyl-L-aspartic acid and reacting it with L-phenylalanine amide or a salt thereof. The acid may be activated by the formation of a mixed anhydride by reaction with a derivative of a sterically hindered organic acid or a derivative of carbonic acid, or by the formation of an active ester or azide or by the use of a condensing agent. Examples relate to the preparation of compounds wherein R is t-butyl and benzyl.
GB2634964A 1964-06-25 1964-06-25 Dipeptide derivatives Expired GB1042481A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
GB2634964A GB1042481A (en) 1964-06-25 1964-06-25 Dipeptide derivatives

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB2634964A GB1042481A (en) 1964-06-25 1964-06-25 Dipeptide derivatives

Publications (1)

Publication Number Publication Date
GB1042481A true GB1042481A (en) 1966-09-14

Family

ID=10242288

Family Applications (1)

Application Number Title Priority Date Filing Date
GB2634964A Expired GB1042481A (en) 1964-06-25 1964-06-25 Dipeptide derivatives

Country Status (1)

Country Link
GB (1) GB1042481A (en)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2549068A1 (en) * 1983-06-27 1985-01-18 Besins Jean Process for the preparation of dipeptides derived from aspartic acid and product obtained using this process
GB2153365A (en) * 1984-01-26 1985-08-21 Pierrel Spa Process for the preparation of N-acyl-derivatives of aspartame
FR2575163A1 (en) * 1984-12-20 1986-06-27 Sanofi Sa TRI-AND REDUCED TETRAPEPTIDES INHIBITORS OF GASTRIC SECRETION, PROCESS FOR OBTAINING THEM AND PHARMACEUTICAL COMPOSITIONS CONTAINING SAME

Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2549068A1 (en) * 1983-06-27 1985-01-18 Besins Jean Process for the preparation of dipeptides derived from aspartic acid and product obtained using this process
GB2153365A (en) * 1984-01-26 1985-08-21 Pierrel Spa Process for the preparation of N-acyl-derivatives of aspartame
FR2575163A1 (en) * 1984-12-20 1986-06-27 Sanofi Sa TRI-AND REDUCED TETRAPEPTIDES INHIBITORS OF GASTRIC SECRETION, PROCESS FOR OBTAINING THEM AND PHARMACEUTICAL COMPOSITIONS CONTAINING SAME
EP0188947A1 (en) * 1984-12-20 1986-07-30 Sanofi S.A. Reduced peptides, inhibitors of gastric secretion, preparation process and pharmaceutical compositions containing them
US4687760A (en) * 1984-12-20 1987-08-18 Sanofi Reduced peptides which inhibit gastric secretion, process for their preparation and pharmaceutical compositions in which they are present

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