GB1040733A - Mycobacteriostatic compositions - Google Patents

Abstract

Soaps, liquid soaps and shampoos based on synthetic detergents contain a mycobacteriostat consisting of a compound having linked to a nitrogen atom of a biguanide either a halogen-containing aliphatic oxyphenyl group, the aliphatic oxy group of which has at least 2 carbon atoms, or an aliphatic oxyphenyl group in which the aliphatic substituent is a hydro-carbon substituent containing from 5 to 9 carbon atoms, or a salt of such a compound. Specified biguanides are those of the formula <FORM:1040733/C4-C5/1> where R is the aliphatic group which may be alkyl, alkenyl, cycloalkyl, or aralkyl. The phenyl nucleus may be further substituted, e.g. with a halogen atom, nitro, amino, aryl, or aliphatic group. A hydrogen atom in the biguanide residue may also be replaced by, for instance, an aliphatic or aromatic group. The salts may either be acid addition or quaternary ammonium salts. The synthetic detergent materials in shampoos may be ionic, e.g. alkali metal salt of a sulphonated olive or castor oil, non-ionic, e.g. an ester or ether of a polyethylene glycol, or a mixture of both types.ALSO:Mycobacteriostatic compositions comprise a base that is pharmaceutically acceptable for external human use and as active ingredient less than 1% by wt. of the composition of a compound having linked to a nitrogen atom of a bignamide either a halogen-containing aliphatic oxyphenyl group, the aliphatic oxy group of which has at least 2 carbon atoms, or an aliphatic oxyphenyl group in which the aliphatic substituent is a hydrocarbon substituent containing from 5 to 9 carbon atoms, or a salt of such a compound. Specified bignamides are those of the formula <FORM:1040733/A5-A6/1> where R is the aliphatic group, which may be alkyl, alkenyl, cycloalkyl, or aralkyl. The phenyl nucleus may be further substituted e.g. it may contain a halogen atom, a nitro, amino, aryl, or aliphatic group (e.g. one of those specified above with reference to R). A hydrogen atom in the bignamide residue may also be replaced by, for instance, an aliphatic or aromatic group. The salts may either be acid addition or quaternary ammonium salts. The compositions may be in the form of ointments i.e. anhydrous solutions or dispersions of the active ingredient in a suitable base e.g. animal, vegetable, or mineral grease such as lard or petroleum jelly, oil e.g. olive, arachis, cottonseed or sesame oil, or wax e.g. beeswax. The base may be an aqueous emulsion in which case the compositions contain either water-in-oil emulsifying agents such as lanolin or wool alcohols or oil-in-water emulsifying agents such as Emulsifying Wax B.P. Ear drops, medicated cosmetic and toilet preparations e.g. hand or body lotions, lipsticks, talcum powders, soaps, liquid soaps and shampoos based on synthetic detergents, may be other forms of the mycobacteriostatic compositions.