GB1036276A - 7,16-dialkyl-pregnanes - Google Patents
7,16-dialkyl-pregnanesInfo
- Publication number
- GB1036276A GB1036276A GB39198/63A GB3919863A GB1036276A GB 1036276 A GB1036276 A GB 1036276A GB 39198/63 A GB39198/63 A GB 39198/63A GB 3919863 A GB3919863 A GB 3919863A GB 1036276 A GB1036276 A GB 1036276A
- Authority
- GB
- United Kingdom
- Prior art keywords
- alkyl
- ethyl
- keto
- ethylenedioxy
- give
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- AZQWKYJCGOJGHM-UHFFFAOYSA-N 1,4-benzoquinone Chemical compound O=C1C=CC(=O)C=C1 AZQWKYJCGOJGHM-UHFFFAOYSA-N 0.000 abstract 4
- -1 alkyl Grignard reagent Chemical class 0.000 abstract 3
- 238000000034 method Methods 0.000 abstract 3
- 239000007818 Grignard reagent Substances 0.000 abstract 2
- DKGAVHZHDRPRBM-UHFFFAOYSA-N Tert-Butanol Chemical compound CC(C)(C)O DKGAVHZHDRPRBM-UHFFFAOYSA-N 0.000 abstract 2
- 125000000217 alkyl group Chemical group 0.000 abstract 2
- 230000001590 oxidative effect Effects 0.000 abstract 2
- 229960003387 progesterone Drugs 0.000 abstract 2
- 239000000186 progesterone Substances 0.000 abstract 2
- JPJALAQPGMAKDF-UHFFFAOYSA-N selenium dioxide Chemical compound O=[Se]=O JPJALAQPGMAKDF-UHFFFAOYSA-N 0.000 abstract 2
- 229930194542 Keto Natural products 0.000 abstract 1
- 241000193386 Lysinibacillus sphaericus Species 0.000 abstract 1
- 241000203720 Pimelobacter simplex Species 0.000 abstract 1
- 230000031709 bromination Effects 0.000 abstract 1
- 238000005893 bromination reaction Methods 0.000 abstract 1
- 125000004432 carbon atom Chemical group C* 0.000 abstract 1
- 238000006243 chemical reaction Methods 0.000 abstract 1
- 238000007269 dehydrobromination reaction Methods 0.000 abstract 1
- 230000003301 hydrolyzing effect Effects 0.000 abstract 1
- 239000002184 metal Substances 0.000 abstract 1
- 230000033116 oxidation-reduction process Effects 0.000 abstract 1
- 238000002360 preparation method Methods 0.000 abstract 1
- 238000010992 reflux Methods 0.000 abstract 1
- 150000003431 steroids Chemical class 0.000 abstract 1
- UGNWTBMOAKPKBL-UHFFFAOYSA-N tetrachloro-1,4-benzoquinone Chemical compound ClC1=C(Cl)C(=O)C(Cl)=C(Cl)C1=O UGNWTBMOAKPKBL-UHFFFAOYSA-N 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/57—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J5/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J7/00—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J75/00—Processes for the preparation of steroids in general
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Epidemiology (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Steroid Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Priority Applications (8)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| BE653974D BE653974A (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) | 1963-10-04 | ||
| GB39198/63A GB1036276A (en) | 1963-10-04 | 1963-10-04 | 7,16-dialkyl-pregnanes |
| CH1233064A CH459197A (de) | 1963-10-04 | 1964-09-23 | Verfahren zur Herstellung von 7a, 16a-Dialkyl-steroiden der Pregnanreihe |
| US399891A US3314976A (en) | 1963-10-04 | 1964-09-28 | 7, 16-dialkyl-pregnanes |
| NL6411287A NL6411287A (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) | 1963-10-04 | 1964-09-29 | |
| DE19641468450 DE1468450A1 (de) | 1963-10-04 | 1964-10-02 | Verfahren zur Herstellung von 6,17-Dialkylsteroiden der Pregnanreihe |
| FR990395A FR1451985A (fr) | 1963-10-04 | 1964-10-05 | Procédé de préparation de 7, 16-dialcoyl-prégnanes |
| BR163117/64A BR6463117D0 (pt) | 1963-10-04 | 1964-10-10 | 7-16-dialquil-pregnanos |
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB39198/63A GB1036276A (en) | 1963-10-04 | 1963-10-04 | 7,16-dialkyl-pregnanes |
| GB914964 | 1964-03-04 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB1036276A true GB1036276A (en) | 1966-07-20 |
Family
ID=26242744
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB39198/63A Expired GB1036276A (en) | 1963-10-04 | 1963-10-04 | 7,16-dialkyl-pregnanes |
Country Status (7)
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CH457420A (de) * | 1965-02-22 | 1968-06-15 | Ciba Geigy | Verfahren zur Herstellung von 3-Oxo-7a-methyl-17-äthylendioxy- 1,4-androstadien |
| EP1242444B1 (en) | 1999-12-29 | 2005-07-20 | THE GOVERNMENT OF THE UNITED STATES OF AMERICA, as represented by THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES | Process for preparing 17alpha-acetoxy-11beta- 4-n,n-(dimethylamino)phenyl]-21-methoxy-19-norpregna-4,9-diene-3,20-dione, intermediates useful in the process, and processes for preparing such intermediates |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3126374A (en) * | 1964-03-24 | J-methyl progesterone derivatives | ||
| US896103A (en) * | 1903-07-31 | 1908-08-18 | Dean Electric Co | Telephone system. |
| US2882282A (en) * | 1957-07-17 | 1959-04-14 | Pfizer & Co C | Method of producing 3-keto-delta4, 6-steroid compounds from 3-keto a-ring saturated 6-dihydro steroid compounds |
| US3002005A (en) * | 1958-10-24 | 1961-09-26 | Upjohn Co | 7-methylprogesterone |
-
0
- BE BE653974D patent/BE653974A/xx unknown
-
1963
- 1963-10-04 GB GB39198/63A patent/GB1036276A/en not_active Expired
-
1964
- 1964-09-23 CH CH1233064A patent/CH459197A/de unknown
- 1964-09-28 US US399891A patent/US3314976A/en not_active Expired - Lifetime
- 1964-09-29 NL NL6411287A patent/NL6411287A/xx unknown
- 1964-10-02 DE DE19641468450 patent/DE1468450A1/de active Pending
- 1964-10-10 BR BR163117/64A patent/BR6463117D0/pt unknown
Also Published As
| Publication number | Publication date |
|---|---|
| BE653974A (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) | |
| DE1468450A1 (de) | 1969-01-09 |
| NL6411287A (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) | 1965-04-05 |
| CH459197A (de) | 1968-07-15 |
| BR6463117D0 (pt) | 1973-07-26 |
| US3314976A (en) | 1967-04-18 |
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