GB1036125A - Process for the purification of cephalosporin c - Google Patents

Process for the purification of cephalosporin c

Info

Publication number
GB1036125A
GB1036125A GB5670/62A GB567062A GB1036125A GB 1036125 A GB1036125 A GB 1036125A GB 5670/62 A GB5670/62 A GB 5670/62A GB 567062 A GB567062 A GB 567062A GB 1036125 A GB1036125 A GB 1036125A
Authority
GB
United Kingdom
Prior art keywords
cephalosporin
aqueous solution
purification
adsorbing
purified
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB5670/62A
Inventor
Edward Penley Abraham
Guy Geoffrey Frederick Newton
Patrick Willoughby Trown
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
NAT RES DEV
National Research Development Corp UK
Original Assignee
NAT RES DEV
National Research Development Corp UK
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by NAT RES DEV, National Research Development Corp UK filed Critical NAT RES DEV
Priority to GB5670/62A priority Critical patent/GB1036125A/en
Priority to FR924396A priority patent/FR1353113A/en
Priority to DE1492049A priority patent/DE1492049C3/en
Priority to SE157363A priority patent/SE314773B/xx
Publication of GB1036125A publication Critical patent/GB1036125A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D501/02—Preparation
    • C07D501/12—Separation; Purification
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P35/00—Preparation of compounds having a 5-thia-1-azabicyclo [4.2.0] octane ring system, e.g. cephalosporin
    • C12P35/06—Cephalosporin C; Derivatives thereof

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Cephalosporin Compounds (AREA)

Abstract

Cephalosporin C is purified by adsorbing it from an aqueous solution on to strong cation exchange material containing sulphonic acid groups and eluting adsorbed material with an alkaline reagent. The aqueous solution may be a fermentation medium from which Cephalosporin N and chloride ions have been removed by known methods.
GB5670/62A 1962-02-14 1962-02-14 Process for the purification of cephalosporin c Expired GB1036125A (en)

Priority Applications (4)

Application Number Priority Date Filing Date Title
GB5670/62A GB1036125A (en) 1962-02-14 1962-02-14 Process for the purification of cephalosporin c
FR924396A FR1353113A (en) 1962-02-14 1963-02-11 Cephalosporin c purification
DE1492049A DE1492049C3 (en) 1962-02-14 1963-02-13 Process for the production of cephalosporin C from a fermented medium containing this antibiotic in addition to cephalosporin N
SE157363A SE314773B (en) 1962-02-14 1963-02-13

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB5670/62A GB1036125A (en) 1962-02-14 1962-02-14 Process for the purification of cephalosporin c

Publications (1)

Publication Number Publication Date
GB1036125A true GB1036125A (en) 1966-07-13

Family

ID=9800446

Family Applications (1)

Application Number Title Priority Date Filing Date
GB5670/62A Expired GB1036125A (en) 1962-02-14 1962-02-14 Process for the purification of cephalosporin c

Country Status (2)

Country Link
GB (1) GB1036125A (en)
SE (1) SE314773B (en)

Also Published As

Publication number Publication date
SE314773B (en) 1969-09-15

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