GB1028913A - Basically substituted diphenyl-methyl ethers, processes for their manufacture and their use - Google Patents
Basically substituted diphenyl-methyl ethers, processes for their manufacture and their useInfo
- Publication number
- GB1028913A GB1028913A GB5541/63A GB554163A GB1028913A GB 1028913 A GB1028913 A GB 1028913A GB 5541/63 A GB5541/63 A GB 5541/63A GB 554163 A GB554163 A GB 554163A GB 1028913 A GB1028913 A GB 1028913A
- Authority
- GB
- United Kingdom
- Prior art keywords
- compound
- phenyl
- formula
- hydrogen atom
- condensing
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Landscapes
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
The invention comprises compounds of the formula <FORM:1028913/C2/1> in which R and R1 each represents a hydrogen or halogen atom, a C1-3 alkyl group or a C1-3 alkoxy group, R2 represents a hydrogen atom or a methyl group and R4 and R5 each represents a hydrogen atom or a methoxy group, and their physiologically tolerable acid addition salts. The compounds may be prepared by (a) condensing an amine of the formula <FORM:1028913/C2/2> with a phenyl acetone compound, which may be substituted by one or two methoxy groups in the phenyl nucleus, with simultaneous or subsequent hydrogenation, or (b) condensing an amine of Formula II with a 1-phenyl-2-halopropane compound or a 1-phenyl-2-halo-propene compound, which may be substituted by one or two methoxy groups in the phenyl nucleus, and when a propene compound is used, hydrogenating the product, or (c) condensing a compound of the formula <FORM:1028913/C2/3> in which Hal represents Cl, Br or I with a 1-phenyl-2-amino propane compound which may be substituted by one or two methoxy groups in the phenyl nucleus, or (d) condensing a benzhydrol compound, the phenyl moieties of which may each be substituted by a halogen atom or a C1-3 alkyl or C1-3 alkoxy group, with a compound of the formula <FORM:1028913/C2/4> in which R3 represents a hydrogen atom or a methyl or benzyl group, and, if R3 represents a benzyl group, hydrogenating the product to replace the benzyl group by a hydrogen atom, or (e) condensing a diphenyl-bromomethane compound, the phenyl moieties of which may each be substituted by a halogen atom or a C1-3 alkyl or C1-3 alkoxy group, with a compound of the formula <FORM:1028913/C2/5> and, if R3 represents a benzyl group, hydrogenating the product to replace the benzyl group by a hydrogen atom, or (f) reducing a compound of the formula <FORM:1028913/C2/6> or (g) N-methylating a compound of the invention in which R2 represents a hydrogen atom. 1 - m - Methoxyphenyl - 2 - (N - chloroethyl-N-methylamino)-propan is prepared by reacting m-methoxyphenylacetone with 2-aminoethanol, hydrogenating the Schiff's base so obtained, methylating the resulting compound and treating the basic alcohol obtained with thionyl chloride. 1 - (3,4 - Dimethoxyphenyl)-2-(N - chloroethyl - N - methylamino) - propane and 1 - (3,5 - dimethoxyphenyl) - 2 - (N - chloroethyl - N - methylamino) - propane are similarly prepared. Pharmaceutical compositions for oral or parenteral administration, having a physiological effect on the heart and blood circulation, comprise a compound of the invention together with a pharmaceutically acceptable carrier. The compositions may be in the form of tablets or drag<\>aees.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DEF0035984 | 1962-02-09 | ||
DEF0037514 | 1962-08-03 |
Publications (1)
Publication Number | Publication Date |
---|---|
GB1028913A true GB1028913A (en) | 1966-05-11 |
Family
ID=25975230
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
GB5541/63A Expired GB1028913A (en) | 1962-02-09 | 1963-02-11 | Basically substituted diphenyl-methyl ethers, processes for their manufacture and their use |
Country Status (11)
Country | Link |
---|---|
AT (6) | AT242686B (en) |
BE (1) | BE628262A (en) |
BR (1) | BR6346803D0 (en) |
CH (6) | CH443352A (en) |
DE (1) | DE1245981B (en) |
DK (4) | DK104890C (en) |
FI (1) | FI40722B (en) |
FR (1) | FR2880M (en) |
GB (1) | GB1028913A (en) |
NL (1) | NL288538A (en) |
OA (1) | OA02646A (en) |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5171752A (en) * | 1990-07-19 | 1992-12-15 | Akzo N.V. | Benzhydryl derivatives having calmodulin inhibitor properties |
Families Citing this family (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB8824262D0 (en) * | 1988-10-17 | 1988-11-23 | Pfizer Ltd | Therapeutic agents |
-
0
- DE DENDAT1245981D patent/DE1245981B/en active Pending
- NL NL288538D patent/NL288538A/xx unknown
- BE BE628262D patent/BE628262A/xx unknown
-
1963
- 1963-02-07 CH CH152463A patent/CH443352A/en unknown
- 1963-02-07 CH CH121067A patent/CH460811A/en unknown
- 1963-02-07 AT AT281864A patent/AT242686B/en active
- 1963-02-07 AT AT95663A patent/AT242119B/en active
- 1963-02-07 AT AT281564A patent/AT242683B/en active
- 1963-02-07 AT AT281764A patent/AT242685B/en active
- 1963-02-07 CH CH121467A patent/CH460049A/en unknown
- 1963-02-07 CH CH121167A patent/CH460046A/en unknown
- 1963-02-07 CH CH121367A patent/CH460048A/en unknown
- 1963-02-07 AT AT281964A patent/AT242687B/en active
- 1963-02-07 AT AT281664A patent/AT242684B/en active
- 1963-02-07 CH CH121267A patent/CH460047A/en unknown
- 1963-02-08 DK DK423764A patent/DK104890C/en active
- 1963-02-08 DK DK61263A patent/DK104943C/en active
- 1963-02-08 BR BR14680363A patent/BR6346803D0/en unknown
- 1963-02-08 FI FI24163A patent/FI40722B/fi active
- 1963-02-08 DK DK423464A patent/DK106283C/en active
- 1963-02-08 DK DK423664A patent/DK104989C/en active
- 1963-02-11 GB GB5541/63A patent/GB1028913A/en not_active Expired
- 1963-05-08 FR FR934139A patent/FR2880M/en active Active
-
1964
- 1964-12-31 OA OA51808A patent/OA02646A/en unknown
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5171752A (en) * | 1990-07-19 | 1992-12-15 | Akzo N.V. | Benzhydryl derivatives having calmodulin inhibitor properties |
Also Published As
Publication number | Publication date |
---|---|
CH460811A (en) | 1968-08-15 |
NL288538A (en) | |
DE1245981B (en) | 1967-08-03 |
DK104989C (en) | 1966-08-01 |
CH460047A (en) | 1968-07-31 |
CH460046A (en) | 1968-07-31 |
CH460049A (en) | 1968-07-31 |
BR6346803D0 (en) | 1973-06-14 |
BE628262A (en) | |
AT242686B (en) | 1965-09-27 |
FR2880M (en) | 1964-11-02 |
DK104890C (en) | 1966-07-18 |
OA02646A (en) | 1970-12-15 |
CH460048A (en) | 1968-07-31 |
CH443352A (en) | 1967-09-15 |
AT242683B (en) | 1965-09-27 |
AT242119B (en) | 1965-08-25 |
AT242685B (en) | 1965-09-27 |
AT242687B (en) | 1965-09-27 |
FI40722B (en) | 1969-01-31 |
DK106283C (en) | 1967-01-16 |
AT242684B (en) | 1965-09-27 |
DK104943C (en) | 1966-07-25 |
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