GB1023793A - The manufacture of benzodiazepine derivatives - Google Patents
The manufacture of benzodiazepine derivativesInfo
- Publication number
- GB1023793A GB1023793A GB26738/63A GB2673863A GB1023793A GB 1023793 A GB1023793 A GB 1023793A GB 26738/63 A GB26738/63 A GB 26738/63A GB 2673863 A GB2673863 A GB 2673863A GB 1023793 A GB1023793 A GB 1023793A
- Authority
- GB
- United Kingdom
- Prior art keywords
- group
- compounds
- nitrogen atom
- acid addition
- salts
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 229940053197 benzodiazepine derivative antiepileptics Drugs 0.000 title 1
- 125000003310 benzodiazepinyl group Chemical class N1N=C(C=CC2=C1C=CC=C2)* 0.000 title 1
- 238000004519 manufacturing process Methods 0.000 title 1
- 150000003839 salts Chemical class 0.000 abstract 5
- 150000001875 compounds Chemical class 0.000 abstract 4
- 229910052757 nitrogen Inorganic materials 0.000 abstract 4
- 125000004433 nitrogen atom Chemical group N* 0.000 abstract 4
- 239000002253 acid Substances 0.000 abstract 3
- 125000000217 alkyl group Chemical group 0.000 abstract 3
- 125000002373 5 membered heterocyclic group Chemical group 0.000 abstract 2
- 125000004070 6 membered heterocyclic group Chemical group 0.000 abstract 2
- 241001061127 Thione Species 0.000 abstract 2
- 125000003282 alkyl amino group Chemical group 0.000 abstract 2
- 125000004663 dialkyl amino group Chemical group 0.000 abstract 2
- 125000005843 halogen group Chemical group 0.000 abstract 2
- 125000004430 oxygen atom Chemical group O* 0.000 abstract 2
- 239000000825 pharmaceutical preparation Substances 0.000 abstract 2
- 229910052783 alkali metal Inorganic materials 0.000 abstract 1
- 150000001340 alkali metals Chemical class 0.000 abstract 1
- 230000002152 alkylating effect Effects 0.000 abstract 1
- 229940125681 anticonvulsant agent Drugs 0.000 abstract 1
- 239000001961 anticonvulsive agent Substances 0.000 abstract 1
- 230000015572 biosynthetic process Effects 0.000 abstract 1
- 239000002775 capsule Substances 0.000 abstract 1
- 239000008298 dragée Substances 0.000 abstract 1
- 239000000839 emulsion Substances 0.000 abstract 1
- 229940035363 muscle relaxants Drugs 0.000 abstract 1
- 239000003158 myorelaxant agent Substances 0.000 abstract 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 1
- 238000002360 preparation method Methods 0.000 abstract 1
- 229940125723 sedative agent Drugs 0.000 abstract 1
- 239000000932 sedative agent Substances 0.000 abstract 1
- 239000000243 solution Substances 0.000 abstract 1
- 125000001424 substituent group Chemical group 0.000 abstract 1
- 239000000725 suspension Substances 0.000 abstract 1
- 239000003826 tablet Substances 0.000 abstract 1
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US20895162A | 1962-07-10 | 1962-07-10 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB1023793A true GB1023793A (en) | 1966-03-23 |
Family
ID=22776727
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB26738/63A Expired GB1023793A (en) | 1962-07-10 | 1963-07-05 | The manufacture of benzodiazepine derivatives |
Country Status (10)
| Country | Link |
|---|---|
| US (1) | US3422091A (en:Method) |
| BE (1) | BE634438A (en:Method) |
| BR (1) | BR6350584D0 (en:Method) |
| CH (1) | CH436316A (en:Method) |
| DE (1) | DE1445878A1 (en:Method) |
| ES (1) | ES289813A1 (en:Method) |
| FR (1) | FR2887M (en:Method) |
| GB (1) | GB1023793A (en:Method) |
| NL (2) | NL126389C (en:Method) |
| SE (2) | SE311018B (en:Method) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3362962A (en) * | 1964-01-24 | 1968-01-09 | Hoffmann La Roche | Certain benzothiazepine derivatives |
| US3987052A (en) * | 1969-03-17 | 1976-10-19 | The Upjohn Company | 6-Phenyl-4H-s-triazolo[4,3-a][1,4]benzodiazepines |
| US3933794A (en) * | 1971-08-04 | 1976-01-20 | The Upjohn Company | 2-(2-Alkynylamino)-3H-1,4-benzodiazepines |
| US4008223A (en) * | 1971-12-09 | 1977-02-15 | Deutsche Gold- Und Silber-Scheideanstalt Vormals Roessler | 6-Aza-3H-1,4-benzodiazepines |
| USRE31071E (en) * | 1971-12-09 | 1982-11-02 | Deutsche Gold- Und Silber-Scheideanstalt Vormals Roessler | 6-Aza-3H-1,4-benzodiazepines |
| US3901881A (en) * | 1972-01-03 | 1975-08-26 | Upjohn Co | 2-thioxo-1h-1,4-benzodiazepine-1-acetic acid alkyl esters |
| US3901879A (en) * | 1973-07-27 | 1975-08-26 | Hoffmann La Roche | 2-(2-hydroxyethylthio)-2,3-dihydro-5-phenyl-1h-1,4-benzodiazepines |
| CH601263A5 (en:Method) * | 1974-10-21 | 1978-06-30 | Hoffmann La Roche | |
| GB1492159A (en) | 1975-09-29 | 1977-11-16 | Upjohn Co | Preparation of imidazo(1,4)benzodiazepines |
| US4375473A (en) * | 1982-01-04 | 1983-03-01 | The Upjohn Company | Method |
| US5141735A (en) * | 1990-06-18 | 1992-08-25 | Hoffman-La Roche, Inc. | Substituted amino-benzodiazepines having anitviral activity |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3019218A (en) * | 1962-01-30 | Process for amination of alpha-halo- | ||
| US2276975A (en) * | 1938-06-09 | 1942-03-17 | Us Rubber Co | Vulcanization accelerator |
| US2985649A (en) * | 1959-09-17 | 1961-05-23 | Pfizer & Co C | Derivatives of thiabenzopyrrocoline, thiabenzopyridocoline and thiazepine |
| US3051701A (en) * | 1959-12-10 | 1962-12-28 | Benzodiazepine compounds | |
| US3040028A (en) * | 1960-01-27 | 1962-06-19 | Union Carbide Corp | Process for separating 1-methylhomopiperazine and homopiperazine |
-
0
- NL NL295083D patent/NL295083A/xx unknown
- BE BE634438D patent/BE634438A/xx unknown
- NL NL126389D patent/NL126389C/xx active
-
1962
- 1962-07-10 US US208951A patent/US3422091A/en not_active Expired - Lifetime
-
1963
- 1963-06-25 CH CH787763A patent/CH436316A/de unknown
- 1963-06-27 DE DE19631445878 patent/DE1445878A1/de active Pending
- 1963-07-05 GB GB26738/63A patent/GB1023793A/en not_active Expired
- 1963-07-06 FR FR940631A patent/FR2887M/fr not_active Expired
- 1963-07-09 BR BR150584/63A patent/BR6350584D0/pt unknown
- 1963-07-09 ES ES0289813A patent/ES289813A1/es not_active Expired
- 1963-07-10 SE SE7679/63A patent/SE311018B/xx unknown
- 1963-07-10 SE SE03419/69A patent/SE364046B/xx unknown
Also Published As
| Publication number | Publication date |
|---|---|
| DE1445878A1 (de) | 1969-04-17 |
| CH436316A (de) | 1967-05-31 |
| NL126389C (en:Method) | |
| SE311018B (en:Method) | 1969-05-27 |
| US3422091A (en) | 1969-01-14 |
| FR2887M (fr) | 1964-11-02 |
| BE634438A (en:Method) | |
| BR6350584D0 (pt) | 1973-07-12 |
| ES289813A1 (es) | 1963-10-16 |
| NL295083A (en:Method) | |
| SE364046B (en:Method) | 1974-02-11 |
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