GB1023003A - Improvements in or relating to mercaptopropionyl glycines and derivatives thereof - Google Patents

Improvements in or relating to mercaptopropionyl glycines and derivatives thereof

Info

Publication number
GB1023003A
GB1023003A GB35077/62A GB3507762A GB1023003A GB 1023003 A GB1023003 A GB 1023003A GB 35077/62 A GB35077/62 A GB 35077/62A GB 3507762 A GB3507762 A GB 3507762A GB 1023003 A GB1023003 A GB 1023003A
Authority
GB
United Kingdom
Prior art keywords
derivative
preparation
alkyl ester
mercaptopropionylglycine
amide
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB35077/62A
Inventor
Itaru Mita
Nobuo Toshioka
Siro Yamamoto
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Santen Pharmaceutical Co Ltd
Original Assignee
Santen Pharmaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to FR906739A priority Critical patent/FR1491204A/en
Application filed by Santen Pharmaceutical Co Ltd filed Critical Santen Pharmaceutical Co Ltd
Priority to GB35077/62A priority patent/GB1023003A/en
Priority to FR3081DA priority patent/FR3081M/en
Publication of GB1023003A publication Critical patent/GB1023003A/en
Expired legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q17/00—Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings
    • A61Q17/04—Topical preparations for affording protection against sunlight or other radiation; Topical sun tanning preparations
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
    • A61K31/197—Carboxylic acids, e.g. valproic acid having an amino group the amino and the carboxyl groups being attached to the same acyclic carbon chain, e.g. gamma-aminobutyric acid [GABA], beta-alanine, epsilon-aminocaproic acid or pantothenic acid
    • A61K31/198—Alpha-amino acids, e.g. alanine or edetic acid [EDTA]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/40—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
    • A61K8/44—Aminocarboxylic acids or derivatives thereof, e.g. aminocarboxylic acids containing sulfur; Salts; Esters or N-acylated derivatives thereof
    • A61K8/447—Aminocarboxylic acids or derivatives thereof, e.g. aminocarboxylic acids containing sulfur; Salts; Esters or N-acylated derivatives thereof containing sulfur
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/67—Vitamins
    • A61K8/676—Ascorbic acid, i.e. vitamin C
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/10—Anti-acne agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C321/00—Thiols, sulfides, hydropolysulfides or polysulfides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
    • C07C323/50—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton
    • C07C323/51—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton
    • C07C323/52—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being acyclic and saturated

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Dermatology (AREA)
  • Epidemiology (AREA)
  • Medicinal Chemistry (AREA)
  • Birds (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

The invention comprises (a) a - and b -mercaptopropionylglycine and their preparation by (i) hydrolysing the corresponding S-acetyl, benzoyl, nitrobenzoyl or HO3S-derivative or an alkyl ester thereof, (ii) reducing the corresponding S- benzyl or nitrobenzyl derivative or bis-mercaptopropionylglycine, or (iii) treating the corresponding S- benzoyl or alkoxythiocarbonyl derivative with ammonia followed by an acid, and (b) a - and b -mercaptopropionylglycine amide and their preparation by (i) reducing the corresponding S- benzyl derivative or bis-(mercaptopropionylglycine amide), or (ii) treating the corresponding S- benzoyl derivative or an alkyl ester of the S- benzoyl derivative of the corresponding acid with ammonia. The starting materials for the preparation of the acids are obtained by reacting glycine with an appropriate S- substituted mercaptoproprionyl halide or a halopropionyl-glycine or an alkyl ester thereof with an appropriate sulphur compound, and the starting materials for the preparation of the amides are obtained by reacting glycine amide or a glycine alkyl ester with an appropriate S- substituted mercaptopropionyl halide or a halopropionylglycine amide or halopropionylglycine alkyl ester with an appropriate sulphur compound. The preparation of a number of S- substituted mercaptopropionyl halides from the parent acids is described. The compounds of the invention may be used as antidotes in various types of poisoning.
GB35077/62A 1962-08-10 1962-09-14 Improvements in or relating to mercaptopropionyl glycines and derivatives thereof Expired GB1023003A (en)

Priority Applications (3)

Application Number Priority Date Filing Date Title
FR906739A FR1491204A (en) 1962-08-10 1962-08-10 Processes for the preparation of alpha- and beta mercaptopropionylglycocoll and their derivatives
GB35077/62A GB1023003A (en) 1962-09-14 1962-09-14 Improvements in or relating to mercaptopropionyl glycines and derivatives thereof
FR3081DA FR3081M (en) 1962-08-10 1962-10-22 Α- and β-mercaptopropionylglycocolles and their derivatives.

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB35077/62A GB1023003A (en) 1962-09-14 1962-09-14 Improvements in or relating to mercaptopropionyl glycines and derivatives thereof

Publications (1)

Publication Number Publication Date
GB1023003A true GB1023003A (en) 1966-03-16

Family

ID=10373525

Family Applications (1)

Application Number Title Priority Date Filing Date
GB35077/62A Expired GB1023003A (en) 1962-08-10 1962-09-14 Improvements in or relating to mercaptopropionyl glycines and derivatives thereof

Country Status (2)

Country Link
FR (2) FR1491204A (en)
GB (1) GB1023003A (en)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3971828A (en) * 1972-10-03 1976-07-27 Santen Pharmaceutical Co. Ltd. N-(mercaptoacyl)aminoacids
US4346234A (en) * 1978-06-16 1982-08-24 Pietro Gargani Process for the preparation of the sodium salt of mercaptopropionylglycine
US4453008A (en) * 1981-06-01 1984-06-05 Mitsui Toatsu Chemicals, Inc. Production process of DL-cystein

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3857951A (en) * 1973-09-14 1974-12-31 Cassenne Lab Sa Use of 2-mercaptopropionylglycine and its alkali metal salts in treating respiratory diseases
JPS535112A (en) * 1976-03-08 1978-01-18 Santen Pharmaceutical Co Ltd New cysteine derivatives
US4339600A (en) * 1976-05-10 1982-07-13 E. R. Squibb & Sons, Inc. Compounds for alleviating angiotensin related hypertension
US4091024A (en) * 1976-12-03 1978-05-23 E. R. Squibb & Sons, Inc. Pyrrolidine and piperidine-2-carboxylic acid derivatives
US4108886A (en) * 1977-03-11 1978-08-22 E. R. Squibb & Sons, Inc. Thiopropanoylamino acid derivatives
FR2427821A1 (en) * 1978-06-05 1980-01-04 Proter Spa Mercapto:propionamido-acetic acid deriv. mucolytic compsns. - used e.g. orally, parenterally, rectally or by inhalation
IT1101261B (en) * 1978-10-31 1985-09-28 Proter Spa THYOLIC DERIVATIVE FOR THE TREATMENT OF CELLULITE
FR2480747A1 (en) * 1980-04-17 1981-10-23 Roques Bernard AMINO ACID DERIVATIVES AND THEIR THERAPEUTIC APPLICATION
WO2009006773A1 (en) * 2007-07-12 2009-01-15 Nanjing Sanhome Pharmaceutical Co., Ltd. AN OPTICALLY ACTIVE N- (α-MERCAPTOPROPIONY) GLYCINE

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3971828A (en) * 1972-10-03 1976-07-27 Santen Pharmaceutical Co. Ltd. N-(mercaptoacyl)aminoacids
US4346234A (en) * 1978-06-16 1982-08-24 Pietro Gargani Process for the preparation of the sodium salt of mercaptopropionylglycine
US4453008A (en) * 1981-06-01 1984-06-05 Mitsui Toatsu Chemicals, Inc. Production process of DL-cystein

Also Published As

Publication number Publication date
FR1491204A (en) 1967-08-11
FR3081M (en) 1965-01-25

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