GB0900461D0 - Photodynamic therapy device - Google Patents

Photodynamic therapy device

Info

Publication number
GB0900461D0
GB0900461D0 GB0900461A GB0900461A GB0900461D0 GB 0900461 D0 GB0900461 D0 GB 0900461D0 GB 0900461 A GB0900461 A GB 0900461A GB 0900461 A GB0900461 A GB 0900461A GB 0900461 D0 GB0900461 D0 GB 0900461D0
Authority
GB
United Kingdom
Prior art keywords
therapy device
photodynamic therapy
photodynamic
therapy
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
GB0900461A
Other languages
English (en)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Photocure ASA
Original Assignee
Photocure ASA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Photocure ASA filed Critical Photocure ASA
Priority to GB0900461A priority Critical patent/GB0900461D0/en
Publication of GB0900461D0 publication Critical patent/GB0900461D0/en
Priority to GB0916666A priority patent/GB0916666D0/en
Priority to US13/144,222 priority patent/US20110295186A1/en
Priority to MX2014003916A priority patent/MX374278B/es
Priority to SG2011041761A priority patent/SG172028A1/en
Priority to PL09801405T priority patent/PL2382009T3/pl
Priority to CA2748144A priority patent/CA2748144C/en
Priority to PCT/EP2009/009037 priority patent/WO2010078929A1/en
Priority to AU2009336871A priority patent/AU2009336871B2/en
Priority to PT121884217T priority patent/PT2545962E/pt
Priority to EP12188421.7A priority patent/EP2545962B1/en
Priority to SI200931312T priority patent/SI2545962T1/sl
Priority to NZ593894A priority patent/NZ593894A/en
Priority to CN200980153667.2A priority patent/CN102271760B/zh
Priority to KR1020117015567A priority patent/KR101714092B1/ko
Priority to ES12188421.7T priority patent/ES2552662T3/es
Priority to MX2011007377A priority patent/MX2011007377A/es
Priority to HK12104766.0A priority patent/HK1164191B/xx
Priority to HUE12188421A priority patent/HUE028003T2/en
Priority to DK09801405.3T priority patent/DK2382009T3/da
Priority to JP2011544801A priority patent/JP5697603B2/ja
Priority to RU2011122954/14A priority patent/RU2487740C2/ru
Priority to DK12188421.7T priority patent/DK2545962T3/en
Priority to PT09801405T priority patent/PT2382009E/pt
Priority to CN201610325680.3A priority patent/CN106039580B/zh
Priority to PL12188421T priority patent/PL2545962T3/pl
Priority to EP09801405A priority patent/EP2382009B1/en
Priority to BRPI0923955-3A priority patent/BRPI0923955B1/pt
Priority to SG10201508271PA priority patent/SG10201508271PA/en
Priority to RU2013114432A priority patent/RU2619790C2/ru
Priority to ES09801405T priority patent/ES2398197T3/es
Priority to ZA2011/04660A priority patent/ZA201104660B/en
Priority to US13/595,167 priority patent/US20120330219A1/en
Priority to US14/700,501 priority patent/US20150231407A1/en
Priority to US15/362,112 priority patent/US10874875B2/en
Priority to HK16113854.0A priority patent/HK1225676B/zh
Ceased legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N5/00—Radiation therapy
    • A61N5/06—Radiation therapy using light
    • A61N5/0613—Apparatus adapted for a specific treatment
    • A61N5/062—Photodynamic therapy, i.e. excitation of an agent
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/0059—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence
    • A61B5/0082—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence adapted for particular medical purposes
    • A61B5/0084—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence adapted for particular medical purposes for introduction into the body, e.g. by catheters
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B6/00—Apparatus or devices for radiation diagnosis; Apparatus or devices for radiation diagnosis combined with radiation therapy equipment
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
    • A61K31/22—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin
    • A61K31/221—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin with compounds having an amino group, e.g. acetylcholine, acetylcarnitine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K41/00—Medicinal preparations obtained by treating materials with wave energy or particle radiation ; Therapies using these preparations
    • A61K41/0057—Photodynamic therapy with a photosensitizer, i.e. agent able to produce reactive oxygen species upon exposure to light or radiation, e.g. UV or visible light; photocleavage of nucleic acids with an agent
    • A61K41/0061—5-aminolevulinic acid-based PDT: 5-ALA-PDT involving porphyrins or precursors of protoporphyrins generated in vivo from 5-ALA
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0034—Urogenital system, e.g. vagina, uterus, cervix, penis, scrotum, urethra, bladder; Personal lubricants
    • A61K9/0036—Devices retained in the vagina or cervix for a prolonged period, e.g. intravaginal rings, medicated tampons, medicated diaphragms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M31/00—Devices for introducing or retaining media, e.g. remedies, in cavities of the body
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N5/00—Radiation therapy
    • A61N5/06—Radiation therapy using light
    • A61N5/0601—Apparatus for use inside the body
    • A61N5/0603—Apparatus for use inside the body for treatment of body cavities
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/10—Anti-acne agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N5/00—Radiation therapy
    • A61N5/06—Radiation therapy using light
    • A61N5/0601—Apparatus for use inside the body
    • A61N5/0603—Apparatus for use inside the body for treatment of body cavities
    • A61N2005/0608—Rectum
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N5/00—Radiation therapy
    • A61N5/06—Radiation therapy using light
    • A61N5/0601—Apparatus for use inside the body
    • A61N5/0603—Apparatus for use inside the body for treatment of body cavities
    • A61N2005/0611—Vagina
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N5/00—Radiation therapy
    • A61N5/06—Radiation therapy using light
    • A61N2005/0626—Monitoring, verifying, controlling systems and methods
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N5/00—Radiation therapy
    • A61N5/06—Radiation therapy using light
    • A61N2005/0635—Radiation therapy using light characterised by the body area to be irradiated
    • A61N2005/0643—Applicators, probes irradiating specific body areas in close proximity
    • A61N2005/0645—Applicators worn by the patient
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N5/00—Radiation therapy
    • A61N5/06—Radiation therapy using light
    • A61N2005/065—Light sources therefor
    • A61N2005/0651—Diodes
    • A61N2005/0652—Arrays of diodes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N5/00—Radiation therapy
    • A61N5/06—Radiation therapy using light
    • A61N2005/0658—Radiation therapy using light characterised by the wavelength of light used
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N5/00—Radiation therapy
    • A61N5/06—Radiation therapy using light

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Biomedical Technology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical & Material Sciences (AREA)
  • Pathology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Radiology & Medical Imaging (AREA)
  • Biophysics (AREA)
  • Epidemiology (AREA)
  • Molecular Biology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Medical Informatics (AREA)
  • Surgery (AREA)
  • Organic Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Reproductive Health (AREA)
  • Emergency Medicine (AREA)
  • Physics & Mathematics (AREA)
  • Dermatology (AREA)
  • Urology & Nephrology (AREA)
  • Biochemistry (AREA)
  • Gynecology & Obstetrics (AREA)
  • Hematology (AREA)
  • Anesthesiology (AREA)
  • Optics & Photonics (AREA)
  • High Energy & Nuclear Physics (AREA)
  • Otolaryngology (AREA)
  • Radiation-Therapy Devices (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Infusion, Injection, And Reservoir Apparatuses (AREA)
GB0900461A 2009-01-12 2009-01-12 Photodynamic therapy device Ceased GB0900461D0 (en)

Priority Applications (36)

Application Number Priority Date Filing Date Title
GB0900461A GB0900461D0 (en) 2009-01-12 2009-01-12 Photodynamic therapy device
GB0916666A GB0916666D0 (en) 2009-01-12 2009-09-22 Photodynamic therapy device
ES09801405T ES2398197T3 (es) 2009-01-12 2009-12-16 Disposiitvo de irradiación
MX2011007377A MX2011007377A (es) 2009-01-12 2009-12-16 Dispositivo de irradiacion.
DK09801405.3T DK2382009T3 (da) 2009-01-12 2009-12-16 Bestrålingsindretning
SG2011041761A SG172028A1 (en) 2009-01-12 2009-12-16 Irradiation device
PL09801405T PL2382009T3 (pl) 2009-01-12 2009-12-16 Urządzenie do napromieniania
CA2748144A CA2748144C (en) 2009-01-12 2009-12-16 Irradiation device
PCT/EP2009/009037 WO2010078929A1 (en) 2009-01-12 2009-12-16 Irradiation device
AU2009336871A AU2009336871B2 (en) 2009-01-12 2009-12-16 Irradiation device
PT121884217T PT2545962E (pt) 2009-01-12 2009-12-16 Dispositivo de irradiação
EP12188421.7A EP2545962B1 (en) 2009-01-12 2009-12-16 Irradiation Device
SI200931312T SI2545962T1 (sl) 2009-01-12 2009-12-16 Obsevalna naprava
NZ593894A NZ593894A (en) 2009-01-12 2009-12-16 Irradiation device
CN200980153667.2A CN102271760B (zh) 2009-01-12 2009-12-16 放射装置
KR1020117015567A KR101714092B1 (ko) 2009-01-12 2009-12-16 광 조사 장치
ES12188421.7T ES2552662T3 (es) 2009-01-12 2009-12-16 Dispositivo de irradiación
US13/144,222 US20110295186A1 (en) 2009-01-12 2009-12-16 Irradiation device
HK12104766.0A HK1164191B (en) 2009-01-12 2009-12-16 Irradiation device
HUE12188421A HUE028003T2 (en) 2009-01-12 2009-12-16 Irradiation device
MX2014003916A MX374278B (es) 2009-01-12 2009-12-16 Dispositivo de irradiacion.
JP2011544801A JP5697603B2 (ja) 2009-01-12 2009-12-16 照射装置
RU2011122954/14A RU2487740C2 (ru) 2009-01-12 2009-12-16 Устройство облучения
DK12188421.7T DK2545962T3 (en) 2009-01-12 2009-12-16 irradiation Facilities
PT09801405T PT2382009E (pt) 2009-01-12 2009-12-16 Dispositivo de irradiação
CN201610325680.3A CN106039580B (zh) 2009-01-12 2009-12-16 放射装置、套件和混合物
PL12188421T PL2545962T3 (pl) 2009-01-12 2009-12-16 Urządzenie do napromieniania
EP09801405A EP2382009B1 (en) 2009-01-12 2009-12-16 Irradiation device
BRPI0923955-3A BRPI0923955B1 (pt) 2009-01-12 2009-12-16 Dispositivo de irradiação
SG10201508271PA SG10201508271PA (en) 2009-01-12 2009-12-16 Irradiation device
RU2013114432A RU2619790C2 (ru) 2009-01-12 2009-12-16 Устройство облучения
ZA2011/04660A ZA201104660B (en) 2009-01-12 2011-06-23 Irradiation device
US13/595,167 US20120330219A1 (en) 2009-01-12 2012-08-27 Irradiation device
US14/700,501 US20150231407A1 (en) 2009-01-12 2015-04-30 Irradiation device
US15/362,112 US10874875B2 (en) 2009-01-12 2016-11-28 Irradiation device
HK16113854.0A HK1225676B (zh) 2009-01-12 2016-12-05 放射装置、套件和混合物

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB0900461A GB0900461D0 (en) 2009-01-12 2009-01-12 Photodynamic therapy device

Publications (1)

Publication Number Publication Date
GB0900461D0 true GB0900461D0 (en) 2009-02-11

Family

ID=40379469

Family Applications (2)

Application Number Title Priority Date Filing Date
GB0900461A Ceased GB0900461D0 (en) 2009-01-12 2009-01-12 Photodynamic therapy device
GB0916666A Ceased GB0916666D0 (en) 2009-01-12 2009-09-22 Photodynamic therapy device

Family Applications After (1)

Application Number Title Priority Date Filing Date
GB0916666A Ceased GB0916666D0 (en) 2009-01-12 2009-09-22 Photodynamic therapy device

Country Status (21)

Country Link
US (4) US20110295186A1 (https=)
EP (2) EP2382009B1 (https=)
JP (1) JP5697603B2 (https=)
KR (1) KR101714092B1 (https=)
CN (2) CN106039580B (https=)
AU (1) AU2009336871B2 (https=)
BR (1) BRPI0923955B1 (https=)
CA (1) CA2748144C (https=)
DK (2) DK2382009T3 (https=)
ES (2) ES2552662T3 (https=)
GB (2) GB0900461D0 (https=)
HU (1) HUE028003T2 (https=)
MX (2) MX2011007377A (https=)
NZ (1) NZ593894A (https=)
PL (2) PL2545962T3 (https=)
PT (2) PT2382009E (https=)
RU (2) RU2487740C2 (https=)
SG (2) SG10201508271PA (https=)
SI (1) SI2545962T1 (https=)
WO (1) WO2010078929A1 (https=)
ZA (1) ZA201104660B (https=)

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US20220257969A1 (en) * 2008-07-01 2022-08-18 Ralph Zipper Method for treating pelvic pain, chronic prostatitis, and or overactive bladder symptoms
US20220280236A1 (en) * 2008-07-01 2022-09-08 Ralph Zipper System and method for applying controlled dosage light therapy for treatment of body tissue
US20220273367A1 (en) * 2008-07-01 2022-09-01 Ralph Zipper System and method for applying controlled dosage light therapy for treatment of body tissue
RU2526803C2 (ru) 2009-06-11 2014-08-27 ФотоКьюэр АСА Полутвердые композиции и фармацевтические продукты
CA2790827A1 (en) 2010-03-01 2011-09-09 Photocure Asa Cosmetic compositions
JP5991970B2 (ja) * 2010-07-09 2016-09-14 フォトキュア エイエスエイ 光力学的治療または光力学的診断で使用する乾燥組成物および当該乾燥組成物を含む装置
CN103459551B (zh) * 2011-01-27 2016-06-15 日东电工株式会社 包含任意取代的三联苯和四联苯化合物的光疗装置和方法
ITRN20110014A1 (it) * 2011-02-25 2011-05-27 M & T Srl Dispositivio di irradiazione luminosa della superficie interna di organi
RU2615870C2 (ru) * 2011-12-19 2017-04-11 ФотоКьюэр АСА Устройство облучения
US9550072B2 (en) * 2012-08-03 2017-01-24 Cerca Solutions, LLC Diagnostic device, therapeutic device, and uses thereof
US20140067024A1 (en) * 2012-08-30 2014-03-06 Photocure Asa Dual panel photodynamic therapy lamp
KR101425722B1 (ko) * 2012-11-01 2014-08-01 홍지인 광역학 다중파장 질염 치료 장치
GB201306369D0 (en) * 2013-04-09 2013-05-22 Photocure As Irradiation device
USD750269S1 (en) 2013-04-09 2016-02-23 Photocure Asa Light treatment apparatus
GB2517707B (en) 2013-08-28 2020-09-02 Pci Biotech As A device for light-induced rupture of endocytic vesicles to effect the delivery of an antigen
US10004918B2 (en) * 2014-07-03 2018-06-26 Gregg Alan Klang LED based vaginal light therapy device
RU2609995C2 (ru) * 2015-07-28 2017-02-07 Владимир Анатольевич Дуванский Способ фотодинамической терапии фоновых и предраковых заболеваний шейки матки
KR102443267B1 (ko) * 2016-06-17 2022-09-14 쏘흐본느 유니베흐시테 제어된 광도로 물체를 비추는 장치 및 관련 방법
US11251635B2 (en) 2017-12-19 2022-02-15 Welch Allyn, Inc. Vital signs monitor with a removable and dischargable battery
US20200324137A1 (en) * 2017-12-20 2020-10-15 Public University Corporation Nagoya City University Ultraviolet irradiation device, attachment and elastic member for use in ultraviolet irradiation device, and ultraviolet irradiation method
RU181756U1 (ru) * 2018-04-16 2018-07-26 Азат Раимович Гильфанов Устройство для фотодинамической фотосенсибилизирующей терапии
IL285384B2 (en) 2019-02-13 2024-11-01 Alpheus Medical Inc Non-invasive sonodynamic therapy
US11944842B2 (en) * 2019-12-20 2024-04-02 Gyrus Acmi, Inc. Photodynamic therapy device and methods of use
EP4138997A4 (en) * 2020-04-20 2024-04-24 Cern Corp. Vaginal light therapy devices and methods for using them
WO2022032283A2 (en) 2020-08-07 2022-02-10 Alpheus Medical, Inc. Ultrasound arrays for enhanced sonodynamic therapy for treating cancer
EP4281178B1 (de) * 2021-01-22 2026-02-25 MEDLight GmbH Penisring
DE102022201337A1 (de) 2022-02-09 2023-08-10 Richard Wolf Gmbh Bestrahlungsvorrichtung für die photodynamische Therapie
WO2025217642A1 (en) * 2024-04-12 2025-10-16 The General Hospital Corporation System and method of treating vaginal infections and inflammation

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