GB0614750D0 - Process for preparing pyrrolo[2, 1-c] [1,4] benzodiazepine hybrids - Google Patents

Process for preparing pyrrolo[2, 1-c] [1,4] benzodiazepine hybrids

Info

Publication number
GB0614750D0
GB0614750D0 GBGB0614750.8A GB0614750A GB0614750D0 GB 0614750 D0 GB0614750 D0 GB 0614750D0 GB 0614750 A GB0614750 A GB 0614750A GB 0614750 D0 GB0614750 D0 GB 0614750D0
Authority
GB
United Kingdom
Prior art keywords
benzodiazepine hybrids
preparing pyrrolo
pyrrolo
preparing
benzodiazepine
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
GBGB0614750.8A
Other versions
GB2424883A (en
GB2424883B (en
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Council of Scientific and Industrial Research CSIR
Original Assignee
Council of Scientific and Industrial Research CSIR
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Council of Scientific and Industrial Research CSIR filed Critical Council of Scientific and Industrial Research CSIR
Publication of GB0614750D0 publication Critical patent/GB0614750D0/en
Publication of GB2424883A publication Critical patent/GB2424883A/en
Application granted granted Critical
Publication of GB2424883B publication Critical patent/GB2424883B/en
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A61K31/551—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having two nitrogen atoms, e.g. dilazep
    • A61K31/5513—1,4-Benzodiazepines, e.g. diazepam or clozapine
    • A61K31/5517—1,4-Benzodiazepines, e.g. diazepam or clozapine condensed with five-membered rings having nitrogen as a ring hetero atom, e.g. imidazobenzodiazepines, triazolam
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
GB0614750A 2003-12-31 2003-12-31 Process for preparing pyrrolo[2, 1-c] [1,4] benzodiazepine hybrids Expired - Fee Related GB2424883B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PCT/IN2003/000462 WO2005063759A1 (en) 2003-12-31 2003-12-31 PROCESS FOR PREPARING PYRROLO[2, 1-c] [1, 4] BENZODIAZEPINE HYBRIDS

Publications (3)

Publication Number Publication Date
GB0614750D0 true GB0614750D0 (en) 2006-09-06
GB2424883A GB2424883A (en) 2006-10-11
GB2424883B GB2424883B (en) 2008-10-22

Family

ID=34717579

Family Applications (1)

Application Number Title Priority Date Filing Date
GB0614750A Expired - Fee Related GB2424883B (en) 2003-12-31 2003-12-31 Process for preparing pyrrolo[2, 1-c] [1,4] benzodiazepine hybrids

Country Status (4)

Country Link
JP (1) JP4520411B2 (en)
AU (1) AU2003300718A1 (en)
GB (1) GB2424883B (en)
WO (1) WO2005063759A1 (en)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP5149193B2 (en) * 2005-11-10 2013-02-20 カウンスィル オブ サイエンティフィック アンド インダストリアル リサーチ Novel pyrrolo [2,1-c] [1,4] benzodiazepine hybrids and methods for their preparation
US8063204B2 (en) 2007-02-13 2011-11-22 Council Of Scientific & Industrial Research Benzothiazole and benzoxazole linked pyrrolo[2,1-c] [1, 4] benzodiazepine hybrids as novel antitumour agents and process for the preparation thereof
GB2469980B (en) * 2008-03-05 2012-02-22 Council Scient Ind Res Naphthalimide-benzimidazole hybrids as potential antitumour agents and process for the preparation thereof
WO2009113085A1 (en) * 2008-03-11 2009-09-17 Council Of Scientific & Industrial Research Novel benzimidazole linked pyrrolo[2,1-q[1,4] benzodiazepine hybrids as potential antitumour agents and process for the preparation thereof
EP2271648B1 (en) 2008-03-26 2013-02-13 Council of Scientific & Industrial Research Isoxazoline linked pyrrolo [2,1-c][1,4]benzodiazepine hybrids as potential anticancer agents and the process for preparattion thereof
US8592407B2 (en) 2008-11-19 2013-11-26 Council Of Scientific & Industrial Research Pyrrolo[2,1-c][1,4] benzodiazepine derivatives with dithiocarbamate side chains and process for the preparation thereof
PL3325482T3 (en) 2015-07-21 2021-01-11 Immunogen, Inc. Methods of preparing cytotoxic benzodiazepine derivatives

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2244210T3 (en) * 1998-08-27 2005-12-01 Spirogen Limited PIRROLOBENZODIAZEPINAS.

Also Published As

Publication number Publication date
GB2424883A (en) 2006-10-11
WO2005063759A1 (en) 2005-07-14
JP2007528343A (en) 2007-10-11
GB2424883B (en) 2008-10-22
JP4520411B2 (en) 2010-08-04
AU2003300718A1 (en) 2005-07-21

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Legal Events

Date Code Title Description
PCNP Patent ceased through non-payment of renewal fee

Effective date: 20171231